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Phosphorylation & G-Protein Mediated Signaling Networks (GRS)
Gordon Research Seminar

New Approaches to Characterizing Molecular Mechanisms of Disease

Dates

June 14-15, 2014

Location

University of New England
Biddeford, ME

Organizers

Chair:
Aileen Klein

Associate Chair:
Adam Coster

Meeting Description

The Gordon Research Seminar on Phosphorylation & G-Protein Mediated Signaling Networks is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The goal of this meeting is to provide a forum for the exchange of new concepts in the field of kinase and GPCR signaling, with a particular emphasis on novel and quantitative approaches to elucidating physiological and pathological signaling cascades and their interactions. The GRS will additionally bring together young investigators to foster opportunities for future collaborations, and will provide attendees with the most recent advances in this field prior to the Phosphorylation & G-Protein Mediated Signaling Gordon Research Conference.

Related Meeting

This GRS was held in conjunction with the "Phosphorylation & G-Protein Mediated Signaling Networks" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session
Discussion Leader: TBA
3:45 pm - 4:15 pmForest White (Massachusetts Institute of Technology, USA)
"Quantitative Analysis of the Effect of Oncogenic Mutations on Signaling Networks"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmPhysiology of Signal Transduction
Discussion Leader: Jessie English (DFCI, Belfer Institute, HMS, USA)
7:30 pm - 7:50 pmCollin Higgins (The University of Iowa, USA)
"Biophysical Interrogation of Regulator of G Protein Signaling (RGS) Structure and Dynamics Diversity with Chemical Probes"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJeremiah Keyes (Wake Forest University, USA)
"Modulation of ERK Activity by Reversible Cysteine Modification"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJuliana Antonipillai (Victoria University, Austrailia)
"The Role of LIM Kinase 2 (LIMK2) in the Regulation of Platelet Function"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShana Hardy (Purdue University, USA)
"Investigating a New Role of Syk in Processing Bodies and mRNA Metabolism"
9:20 pm - 9:30 pmDiscussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNontraditional Systems of G Protein Signaling
Discussion Leader: Xuewu Zhang (UT Southwestern Medical Center, USA)
9:00 am - 9:20 amDaisuke Urano (The University of North Carolina at Chapel Hill, USA)
"The Ancestral State of G Protein Pathways: Studies in Plants, Trichomononas and Capsaspora"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGanesh Kadamur (UT Southwestern Medical Center, USA)
"Insights into Gβγ Regulation of Phospholipase Cβ"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMario Rossi (National Institutes of Health, USA)
"Hepatocyte-Specific Activation or Disruption of Gi Signaling in Mice Causes Pronounced Changes in Glucose Homeostasis"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCameron Brand (UT Health Science Center, USA)
"Scaffolding Versus Regulation of Adenylyl Cyclase Isoforms by Gβγ"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmNuts and Bolts: Emerging Technologies
Discussion Leader: Michael Kalwat (UT Southwestern Medical Center, USA)
1:30 pm - 1:50 pmJoshua Lubner (University of Connecticut, USA)
"ProPeL: Using E. coli to Generate High Resolution Models of Protein Kinase Specificity"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmKristoff Homan (University of Michigan, USA)
"G Protein-Coupled Receptor Kinase Selective Small Molecule Inhibitors"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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