Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Bridging Theory and Experiment
7:40 pm - 8:15 pm
"Harvesting the Fruits of the Energy Landscape Theory of Protein Folding"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:00 pm
"Modern Kinetics of Protein Folding: A Retrospective"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Real-Time Raman Studies of Amyloid Formation of a-Synuclein Using Segmental 13C-Labeling"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Dynamics: Unfolded to Folded
9:00 am - 9:25 am
"Atomistic Models for the Simulation of Protein Folding"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Barrier Crossing in the Presence of Solvent and Internal Memory Effects"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:45 am
"New Knotted and Links Protein Families? A New Mechanism of Entanglement"
10:45 am - 10:50 am
Discussion
10:50 am - 11:15 am
"Frustration and Folding: A Case Study of a TIM Barrel Protein"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Identifying and Exploiting High-Energy States to Control Proteins Functions"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Physics and Biology of Nucleosomal Assembly and Dynamics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Folding In Vivo and on the Ribosome
7:30 pm - 7:55 pm
"Structure and Dynamics in Co-Translational Protein Folding"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Changing the Cellular Solute Composition to Alter Protein Structure and Stability"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Non-Equilibrium Coupling of Protein Structure and Function to Translation Kinetics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Protein Unfolding and Aggregation Kinetics in Cells"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Disordered Proteins: Dynamics and Function
9:00 am - 9:25 am
"Effects of Post-Translational Modification of Disordered Proteins on Binding and Self-Association"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Function of Intrinsically Disordered Proteins in Regulation of Cellular Stress Response"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Mapping an IDP-Network with Single-Molecule Spectroscopy"
10:55 am - 11:05 am
Discussion
11:05 am - 11:30 am
"New Methods for Generating and Evaluating Conformational Ensembles"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Self-Assembly of Intrinsically Disordered Peptides"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"High-Affinity Binding of Two Intrinsically Disordered Proteins Without Gain of Structure"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Intracellular Phase Separation: A New Paradigm of Protein Assembly
7:30 pm - 7:50 pm
"Phase Separation in Cancer and Neurodegenerative Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Physical Mechanisms of Cell Organization on Micron Length Scales"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Determinants of Sequence-Encoded Coupling Between Single-Chain Properties and Phase Separation in an Archetypal Low Complexity Domain"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Magic Numbers in Protein Phase Separation"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Folding Transitions and Folding Paths
9:00 am - 9:25 am
"Transition Path Times Reveal Multi-Dimensionality and Memory Effects in the Dynamics of Protein Folding"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"On the Universality of Collapse of Polypeptide Chains"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:50 am
"Probing Folding Dynamics of Alpha3D in an Equilibrium AFM-Based SMFS Assay with 1-10 Microsecond Temporal Resolution"
10:50 am - 10:55 am
Discussion
10:55 am - 11:15 am
"Ab Initio Calculation of Time-Resolved CD Spectra in Near UV Region Reveal the Folding Mechanism in Full Atomistic Detail"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Folding Proteins from Decoys"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Towards Improved Biophysical Calculations to Identify Disease-Causing Mutations"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Misfolding and Aggregation
7:30 pm - 7:55 pm
"In Vitro Cross-Reactivity of Parkinson's Disease Protein, Alpha-Synuclein: Consequences for Amyloid Formation"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Kinetic Conformational Networks of Amyloid-Forming Peptides: From Small Piezoelectric FF to Amylin"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Novel Tools for Biophysical Studies of Amyloidogenesis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Proteins Evolve on the Edge of Supramolecular Self-Assembly"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Single Molecule Mechanics of Protein Folding"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Distinguishing Signatures of Folding Mechanisms"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:45 am
"Ultrafast Protein Folding Under Mechanical Force: Experiments and Simulations"
10:45 am - 10:50 am
Discussion
10:50 am - 11:10 am
"Probing Folding and Conformational Dynamics of Intrinsically Disordered Proteins by Single Molecule FRET"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Sub-Millisecond Large-Scale Conformational Changes: Flexibility at the Service of Function"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Chaperone-Guided Folding of Single Proteins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Dynamic Allostery Can Direct Cold Adaptation in Enzymes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Temperature-Dependent Protein Fold Switching"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Investigating the Evolution of Protein Energy Landscapes by Ancestral Sequence Reconstruction"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Co-Evolutionary Fitness Landscapes for Sequence Design and Sequence Capacity Estimation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Understanding Evolution on Multiple Scales: From Protein Folding to Population Genetics and Back"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure