During their life in biological systems, proteins fold, can form hierarchical complexes, dissociate and unfold due to a wide range of external stimuli. What governs protein dynamics in living cells and how their molecular features are connected to cell function and dysfunction are still unsolved challenges. To solve these, new ideas are required from multiple interdisciplinary areas where experts from diverse backgrounds in experiment, theory, and simulation must engage in close collaborations. In our program, we aim to cover a wide range of topics spanning several length and time scales, from protein dynamics at a single-molecule level to molecular assembly at a subcellular scale. We will discuss recent developments in understanding rapid and elementary processes, such as the early stages of protein folding and the behavior of unfolded proteins in complex environments. We will then build on the emerging knowledge of collective protein dynamics in cells, to characterize proteins' regulatory roles in transient processes that promote cellular function. The conference has a successful track record in mentoring and retaining early career scientists and graduate students. To include early-career scientists, the program is being developed in close collaboration with the co-chairs of the Gordon Research Seminar (GRS). We anticipate that this meeting with GRS will continue to serve as the key venue for scientific exchange at the forefront of protein folding dynamics research, for bridging theoretical and experimental approaches, for including diverse topics, and for promoting and mentoring young scientists.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by July 1, 2019. Please check back for updates.
- Keynote Session: New Mechanisms for Regulation Through Protein Folding and Assembly
- Folding In Vivo
- Hierarchical Assembly
- Folding Transitions and Folding Paths
- Folding and Unfolding in Proteostasis
- Disordered Proteins: Form and Function
- Misfolding and Aggregation
- Structural Prediction, Protein Evolution and Artificial Intelligence
- Keynote Session: Protein Folding and Assembly in the Cell