1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Finding the Bottom of the Funnel: Protein Folding Pathways
Natalie Dall (UC Berkeley, United States) and Rishav Mitra (University of Michigan, United States)
3:45 pm - 3:55 pm
Amir Bitran (Harvard University, United States) "Co-Translational Folding Allows Misfolding-Prone Proteins to Circumvent Deep Kinetic Traps"
3:55 pm - 4:00 pm
4:00 pm - 4:10 pm
Wyel Halimeh (Wichita State University, United States) "Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor"
4:10 pm - 4:15 pm
4:15 pm - 4:25 pm
Jennifer Simien (University of Hawaii at Manoa, United States) "Unravelling the Folding and Threading Mechanism of the “Knot-Like” Topology in Leptin"
4:25 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Dynamics, Stability and Function
Juan David Campolargo (University of Illinois at Urbana-Champaign, United States) and Zachary Smith (University of Maryland, United States)
7:30 pm - 7:40 pm
Ian Sitarik (Penn State University, United States) "Near Native Misfolding into Semi- or Non-Functional States is Prevalent Across the Proteome"
7:40 pm - 7:45 pm
7:45 pm - 7:55 pm
Fatema Bhinderwala (University of Pittsburgh, United States) "Enzyme Activity of Small GTPase RhoA in Physiologically Relevant Environments"
7:55 pm - 8:00 pm
8:00 pm - 8:10 pm
Shawn Costello (UC Berkeley, United States) "The SARS-CoV-2 Spike Reversibly Samples an Open-Trimer Conformation Exposing Novel Epitopes"
8:10 pm - 8:15 pm
8:15 pm - 8:25 pm
Kevin Jose Cheng (University of Illinois at Urbana-Champaign, United States) "Encounters on The Membrane: The Role of Charged Peptides in Bilayer Disruption"
8:25 pm - 8:30 pm
8:30 pm - 8:40 pm
Upasana Mallimadugula (Washington University in St. Louis, United States) "How Does Sequence Affect the Dynamics of a Cryptic Allosteric Site in Ebolavirus VP35?"
8:40 pm - 8:45 pm
8:45 pm - 8:55 pm
Claire Stewart (University of North Carolina at Chapel Hill, United States) "Polyethylene Glycols and Protein Stability"
8:55 pm - 9:00 pm
9:00 pm - 9:10 pm
Oleta Johnson (UCSF, United States) "Developing Tools to Probe DNAJB6 Dynamics in PolyQ Disease"
9:10 pm - 9:15 pm
9:15 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Intrinsic Disorder, Complicated Landscapes and Methods to Explore Them
Lu Hong (University of California, San Francisco, United States) and Xingcheng Lin (Massachusetts Institute of Technology, United States)
9:00 am - 9:10 am
Kathryn Lebold (NIH/NIDDK, United States) "Tuning the Formation of Protein-Nucleic Acid Condensates"
9:10 am - 9:15 am
9:15 am - 9:25 am
Emery Usher (The Pennsylvania State University, United States) "Determinants of E3 Ligase Adaptor SPOP Binding to Intrinsically Disordered Substrates"
9:25 am - 9:30 am
9:30 am - 9:40 am
Devlina Chakravarty (National Library of Medicine, United States) "AlphaFold2 Fails to Predict Protein Fold Switching"
9:40 am - 9:45 am
9:45 am - 9:55 am
David Jacobson (University of Colorado Boulder, United States) "Measuring Equilibrium Unfolding Free Energy Changes of Membrane Proteins by Single-Molecule Force Spectroscopy"
9:55 am - 10:00 am
10:00 am - 10:10 am
Dedi Wang (University of Maryland, College Park, United States) "Capturing Protein Conformational Dynamics through Information Bottleneck and Molecular Dynamics"
10:10 am - 10:15 am
10:15 am - 10:25 am
Darian Yang (University of Pittsburgh, United States) "Integrating Fluorinated Amino Acids into the Framework of the AMBER ff15ipq Force Field"
10:25 am - 10:30 am
10:30 am - 10:40 am
Magdalena Topolska (Centre for Genomic Regulation Barcelona, Spain) "Understanding the impact of indels on protein stability and function using deep mutational scanning"
10:40 am - 10:45 am
10:45 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Finding the Mentorship You Need to Succeed
Andrei Gasic (Center for Theoretical Biological Physics; Rice University, United States)
1:30 pm - 2:30 pm
Panel Discussion Finding the Mentorship You Need to Succeed
Alex Holehouse (Washington University School of Medicine, United States)
Anum Glasgow (Columbia University, United States)
Lauren Porter (National Institutes of Health, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)