Basic Mechanisms to Biomedical Implications of Protein Trafficking

Protein and lipid processing, transport, and secretion remain central to multiple aspects of physiology and pathology with implications in a wide spectrum of diseases, ranging from developmental disorders to cancer and neurodegeneration. Topics of this edition of the GRC will include the molecular mechanisms governing conventional and unconventional secretory pathways, integration of trafficking with nutrient sensing and inter-organelle signaling, and the response of endomembranes to various types of stress including proteotoxic, metabolic and mechanical stress. Daily poster sessions, and short talks selected from abstracts will ensure broad participation. The schedule is designed to provide sufficient opportunities for networking with leaders in the field during free time and communal meals. By the conclusion of the meeting, participants will leave with new insights into the mechanistic, biophysical, and physiological principles of the secretory pathway, and with strengthened connections across the global research community.