Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Molecular Mechanism of Protein Processing and Trafficking
Discussion Leader: James Checco (University of Illinois at Urbana-Champaign, USA)
3:45 pm - 4:20 pm
Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA)
"Molecular Mechanism of Protein Processing and Trafficking"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane and Vesicle Dynamics in Protein Trafficking and Secretion
Discussion Leader: Julie Cruanes (Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Canada)
7:30 pm - 7:45 pm
Jerome Cattin (University of Washington, USA)
"The Conserved Coiled-Coil Protein CCCP1 and the Endosomal Complex EARP Regulate Dense-Core Vesicle Cargo Sorting"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Alessandro Moro (VU University Amsterdam, The Netherlands)
"Dynamin Is Required for Dense-Core Vesicle Exocytosis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Diti Chatterjee Bhowmick (George Washington University, USA)
"Trafficking of Pancreatic Hormone Amylin During Cellular Stress Condition"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Annemiek van Berkel (VU University Medical Center, The Netherlands)
"The Role of Exocytic SNARE Complex Proteins Munc18-1, SNAP25 and Syntaxin-1 in Neuronal Viability"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Tyler Page (University of Utah, USA)
"CAB-1 Is Required at Two Dense Core Vesicle Trafficking Checkpoints"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Exploring the Basis, and Unexpected Functions, of Protein Processing and Trafficking in Health and Disease
Discussion Leader: Afolake Arowolo (University of Cape Town, South Africa)
9:00 am - 9:15 am
Justin Bosch (Harvard Medical School, USA)
"Tissue-of-Origin Identification of Secreted Proteins in the Blood Using TurboID"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Hung-En Hsia (German Center for Neurodegenerative Diseases (DZNE), Germany)
"Substrates and Functions of ADAM10 in the Mammalian Nervous System"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Ilaria Coppola (KU Leuven, Belgium)
"Loss of Furin in β Cells Leads to mTORC1-Dependent Activation of the ATF4 Pathway and β Cell Dysfunction by Limiting Insulin Receptor Processing"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Julia Knopf (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg University, Germany)
"Regulation of Secretion Dynamics by the ER-Resident Intramembrane Protease RHBDL4"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Martin Neukam (Paul Langerhans Institute, Helmholtz Zentrum München, TU Dresden, Germany)
"A Novel Method for the Background-Free Purification of Age-Distinct Insulin Secretory Granules for Proteomic and Lipidomic Analyses"
10:35 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Cutting Edge Analytical Measurement of Protein Processing
Discussion Leader: Stephanie Duval (Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Canada)
1:30 pm - 2:00 pm
Jonathan Sweedler (University of Illinois at Urbana-Champaign, USA)
"Measuring Prohormone Processing in Individual Cells Using Mass Spectrometry"
2:00 pm - 2:10 pm
Discussion
2:10 pm - 2:30 pm
Panel Discussion
Career Options
Klaudia Brix (Jacobs University Bremen, Germany)
Afolake Arowolo (University of Cape Town, South Africa)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
