Novel Techniques to Identify Molecular Mechanisms of Protein Processing and Trafficking

July 14 - 15, 2018

Chairs Stephanie Duval and Stephen C. Ireland

Colby-Sawyer College

541 Main Street

New London, NH, US

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Protein Processing, Trafficking and Secretion is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will cover various advances in typical protein processing as well as unexpected roles of proteases. The meeting will also cover membrane dynamics and vesicle formation with a specific focus on novel technologies to address fundamental questions.

Related Meeting

This GRS will be held in conjunction with the "Protein Processing, Trafficking and Secretion" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Molecular Mechanism of Protein Processing and Trafficking Discussion Leader: James Checco (University of Illinois at Urbana-Champaign, USA)
3:45 pm - 4:20 pm	Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA) "Molecular Mechanism of Protein Processing and Trafficking"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Membrane and Vesicle Dynamics in Protein Trafficking and Secretion Discussion Leader: Julie Cruanes (Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Canada)
7:30 pm - 7:45 pm	Jerome Cattin (University of Washington, USA) "The Conserved Coiled-Coil Protein CCCP1 and the Endosomal Complex EARP Regulate Dense-Core Vesicle Cargo Sorting"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Alessandro Moro (VU University Amsterdam, The Netherlands) "Dynamin Is Required for Dense-Core Vesicle Exocytosis"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Diti Chatterjee Bhowmick (George Washington University, USA) "Trafficking of Pancreatic Hormone Amylin During Cellular Stress Condition"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Annemiek van Berkel (VU University Medical Center, The Netherlands) "The Role of Exocytic SNARE Complex Proteins Munc18-1, SNAP25 and Syntaxin-1 in Neuronal Viability"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Tyler Page (University of Utah, USA) "CAB-1 Is Required at Two Dense Core Vesicle Trafficking Checkpoints"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Exploring the Basis, and Unexpected Functions, of Protein Processing and Trafficking in Health and Disease Discussion Leader: Afolake Arowolo (University of Cape Town, South Africa)
9:00 am - 9:15 am	Justin Bosch (Harvard Medical School, USA) "Tissue-of-Origin Identification of Secreted Proteins in the Blood Using TurboID"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	Hung-En Hsia (German Center for Neurodegenerative Diseases (DZNE), Germany) "Substrates and Functions of ADAM10 in the Mammalian Nervous System"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Ilaria Coppola (KU Leuven, Belgium) "Loss of Furin in β Cells Leads to mTORC1-Dependent Activation of the ATF4 Pathway and β Cell Dysfunction by Limiting Insulin Receptor Processing"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	Julia Knopf (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg University, Germany) "Regulation of Secretion Dynamics by the ER-Resident Intramembrane Protease RHBDL4"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	Martin Neukam (Paul Langerhans Institute, Helmholtz Zentrum München, TU Dresden, Germany) "A Novel Method for the Background-Free Purification of Age-Distinct Insulin Secretory Granules for Proteomic and Lipidomic Analyses"
10:35 am - 10:40 am	Discussion
10:40 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Cutting Edge Analytical Measurement of Protein Processing Discussion Leader: Stephanie Duval (Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Canada)
1:30 pm - 2:00 pm	Jonathan Sweedler (University of Illinois at Urbana-Champaign, USA) "Measuring Prohormone Processing in Individual Cells Using Mass Spectrometry"
2:00 pm - 2:10 pm	Discussion
2:10 pm - 2:30 pm	Panel Discussion Career Options Klaudia Brix (Jacobs University Bremen, Germany) Afolake Arowolo (University of Cape Town, South Africa)
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes