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Saturday
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| 2:00 pm - 5:00 pm |
Arrival and Check-in
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| 3:30 pm - 3:45 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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| 3:45 pm - 4:30 pm |
Keynote Session: Molecular Mechanism of Protein Processing and Trafficking
Discussion Leader: James Checco (University of Illinois at Urbana-Champaign, USA)
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| 3:45 pm - 4:20 pm |
Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA)
"Molecular Mechanism of Protein Processing and Trafficking"
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| 4:20 pm - 4:30 pm |
Discussion
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| 4:30 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Membrane and Vesicle Dynamics in Protein Trafficking and Secretion
Discussion Leader: Julie Cruanes (Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Canada)
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| 7:30 pm - 7:45 pm |
Jerome Cattin (University of Washington, USA)
"The Conserved Coiled-Coil Protein CCCP1 and the Endosomal Complex EARP Regulate Dense-Core Vesicle Cargo Sorting"
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| 7:45 pm - 7:50 pm |
Discussion
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| 7:50 pm - 8:05 pm |
Alessandro Moro (VU University Amsterdam, The Netherlands)
"Dynamin Is Required for Dense-Core Vesicle Exocytosis"
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| 8:05 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:25 pm |
Diti Chatterjee Bhowmick (George Washington University, USA)
"Trafficking of Pancreatic Hormone Amylin During Cellular Stress Condition"
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| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Annemiek van Berkel (VU University Medical Center, The Netherlands)
"The Role of Exocytic SNARE Complex Proteins Munc18-1, SNAP25 and Syntaxin-1 in Neuronal Viability"
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| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:05 pm |
Tyler Page (University of Utah, USA)
"CAB-1 Is Required at Two Dense Core Vesicle Trafficking Checkpoints"
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| 9:05 pm - 9:10 pm |
Discussion
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| 9:10 pm - 9:30 pm |
General Discussion
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Sunday
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| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 11:00 am |
Exploring the Basis, and Unexpected Functions, of Protein Processing and Trafficking in Health and Disease
Discussion Leader: Afolake Arowolo (University of Cape Town, South Africa)
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| 9:00 am - 9:15 am |
Justin Bosch (Harvard Medical School, USA)
"Tissue-of-Origin Identification of Secreted Proteins in the Blood Using TurboID"
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| 9:15 am - 9:20 am |
Discussion
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| 9:20 am - 9:35 am |
Hung-En Hsia (German Center for Neurodegenerative Diseases (DZNE), Germany)
"Substrates and Functions of ADAM10 in the Mammalian Nervous System"
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| 9:35 am - 9:40 am |
Discussion
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| 9:40 am - 9:55 am |
Ilaria Coppola (KU Leuven, Belgium)
"Loss of Furin in β Cells Leads to mTORC1-Dependent Activation of the ATF4 Pathway and β Cell Dysfunction by Limiting Insulin Receptor Processing"
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| 9:55 am - 10:00 am |
Discussion
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| 10:00 am - 10:15 am |
Julia Knopf (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg University, Germany)
"Regulation of Secretion Dynamics by the ER-Resident Intramembrane Protease RHBDL4"
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| 10:15 am - 10:20 am |
Discussion
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| 10:20 am - 10:35 am |
Martin Neukam (Paul Langerhans Institute, Helmholtz Zentrum München, TU Dresden, Germany)
"A Novel Method for the Background-Free Purification of Age-Distinct Insulin Secretory Granules for Proteomic and Lipidomic Analyses"
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| 10:35 am - 10:40 am |
Discussion
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| 10:40 am - 11:00 am |
General Discussion
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| 11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Mentorship Component: Cutting Edge Analytical Measurement of Protein Processing
Discussion Leader: Stephanie Duval (Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Canada)
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| 1:30 pm - 2:00 pm |
Jonathan Sweedler (University of Illinois at Urbana-Champaign, USA)
"Measuring Prohormone Processing in Individual Cells Using Mass Spectrometry"
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| 2:00 pm - 2:10 pm |
Discussion
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| 2:10 pm - 2:30 pm |
Panel Discussion
Career Options
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Klaudia Brix (Jacobs University Bremen, Germany)
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Afolake Arowolo (University of Cape Town, South Africa)
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| 2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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| 3:00 pm |
Seminar Concludes
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