Sunday
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4:00 pm - 8:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Targeting of Substrates to the Membrane Transport Machinery
Discussion Leader: Reid Gilmore (University of Massachusetts Medical School, USA)
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7:40 pm - 7:45 pm |
Introduction by Discussion Leader
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7:45 pm - 8:10 pm |
Judith Frydman (Stanford University, USA)
"Molecular Chaperones and Protein Folding in the Cell"
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8:10 pm - 8:20 pm |
Discussion
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8:20 pm - 8:45 pm |
Shu-Ou Shan (California Institute of Technology, USA)
"Mechanisms of Protein Targeting to Cellular Membranes"
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8:45 pm - 8:55 pm |
Discussion
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8:55 pm - 9:20 pm |
Lynn Richardson (Michigan State University, USA)
"Molecular Topology of the Transit Peptide During Chloroplast Protein Import"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Structure and Mechanisms of Protein Translocases
Discussion Leader: Toshiya Endo (Kyoto Sangyo University, Japan)
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9:00 am - 9:05 am |
Introduction by Discussion Leader
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9:05 am - 9:30 am |
Roland Beckmann (Gene Center Munich, Ludwig Maximilian University of Munich, Germany)
"Structural Insights into Protein Translocation Mechanisms Using Cryo-Electron Microscopy"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:05 am |
William Clemons (California Institute of Technology, USA)
"An Update on Tail-Anchored Targeting from a Structural Perspective"
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10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
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10:45 am - 11:10 am |
Susan Lea (University of Oxford, United Kingdom)
"Structure of the Core of the Type Three Secretion System Export Apparatus"
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11:10 am - 11:20 am |
Discussion
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11:20 am - 11:40 am |
Robert Keenan (University of Chicago, USA)
"Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum"
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11:40 am - 11:45 am |
Discussion
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11:45 am - 12:05 pm |
Steven Theg (University of California, Davis, USA)
"Evaluating the Functional Pore Size of Chloroplast TOC and TIC Protein Translocons: Import of Folded Proteins"
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12:05 pm - 12:10 pm |
Discussion
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12:10 pm - 12:25 pm |
Guillaume Roussel (University of California, Irvine, USA)
"Disposition of E. coli SecA Bound to Lipid Vesicles"
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12:25 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Karen Fleming (Johns Hopkins University, USA) and Meredith Morris (Clemson University, USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Membrane Transport and the Interface of Protein Transport with Transport-Associated Machinery
Discussion Leader: Nathan Alder (University of Connecticut, USA)
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7:30 pm - 7:35 pm |
Introduction by Discussion Leader
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7:35 pm - 7:55 pm |
Paul Jarvis (University of Oxford, United Kingdom)
"Protein Import into Chloroplasts and Its Regulation by the Ubiquitin-Proteasome System"
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7:55 pm - 8:05 pm |
Discussion
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8:05 pm - 8:25 pm |
Nikolaus Pfanner (University of Freiburg, Germany)
"Mitochondrial Machineries for Protein Translocation and Assembly"
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8:25 pm - 8:35 pm |
Discussion
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8:35 pm - 8:55 pm |
Sabine Rospert (University of Freiburg, Germany)
"Functions of Ribosome-Bound Factors in the Yeast Saccharoymces cerevisiae"
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8:55 pm - 9:05 pm |
Discussion
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9:05 pm - 9:25 pm |
Tania de Koning-Ward (Deakin University, Australia)
"Dissecting the Function of Components Comprising the Plasmodium Translocon of Exported P"
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9:25 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Membrane Protein Insertion and Dynamics
Discussion Leader: Ross Dalbey (Ohio State University, USA)
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9:00 am - 9:05 am |
Introduction by Discussion Leader
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9:05 am - 9:30 am |
Karen Fleming (Johns Hopkins University, USA)
"From Chaperones to the Membrane with a BAM!"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:05 am |
Peter Rehling (University Medical Center Gottingen, Germany)
"Mitochondrial Protein Transport Along the Presequence Pathway"
|
10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
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10:45 am - 11:10 am |
Alain Filloux (Imperial College London, United Kingdom)
"Pore-Forming Activity of the Pseudomonas aeruginosa Type III Secretion System Translocon Alters the Host Epigenome"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:40 am |
Kathryn Diederichs (National Institutes of Health, USA)
"Structural Studies of the Mitochondrial Sorting and Assembly Machinery Complex"
|
11:40 am - 11:45 am |
Discussion
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11:45 am - 12:05 pm |
Nir Fluman (Stockholm University, Sweden)
"Protein Dimerization Can Fix a Labile Membrane Protein Topology"
|
12:05 pm - 12:10 pm |
Discussion
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12:10 pm - 12:25 pm |
William Dowhan (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"How the Charge Balance Rule Governs Membrane Protein Topology"
|
12:25 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Origins and Diversity of Membrane Transport Machinery
Discussion Leader: Peter Rehling (University Medical Center Gottingen, Germany)
|
7:30 pm - 7:35 pm |
Introduction by Discussion Leader
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7:35 pm - 8:00 pm |
Nicholas Noinaj (Purdue University, USA)
"Substrate Recognition by the BAM Complex"
|
8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:35 pm |
Toshiya Endo (Kyoto Sangyo University, Japan)
"Mitochondria Protein and Lipid Transport"
|
8:35 pm - 8:45 pm |
Discussion
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8:45 pm - 9:05 pm |
Christopher Carrie (Ludwig-Maximilians-Universität München, Germany)
"The Role of TPR Domains of Plant Mitochondrial Oxa Proteins"
|
9:05 pm - 9:10 pm |
Discussion
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9:10 pm - 9:25 pm |
Donna Fernandez (University of Wisconsin-Madison, USA)
"Dual Sec Translocases and Function of GET3-Related Factors Within Chloroplasts"
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9:25 pm - 9:30 pm |
Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Assembly of Membrane Transport Complexes
Discussion Leader: Carole Dabney-Smith (Miami University, USA)
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9:00 am - 9:05 am |
Introduction by Discussion Leader
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9:05 am - 9:30 am |
Christopher Hayes (University of California, Santa Barbara, USA)
"Receptor-induced Toxin Delivery During Bacterial Contact-Dependent Growth Inhibition (CDI)"
|
9:30 am - 9:40 am |
Discussion
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9:40 am - 10:05 am |
Tracy Palmer (University of Dundee, United Kingdom)
"The Transport of Proteins by the Twin Arginine Protein Transport Pathway"
|
10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
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10:45 am - 11:05 am |
Sichen Shao (Harvard Medical School, USA)
"Mechanisms of Tail-Anchored Protein Triage"
|
11:05 am - 11:15 am |
Discussion
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11:15 am - 11:40 am |
Hui Jiang (National Institute of Biological Sciences, Beijing, China)
"Molecular Pathways of Mitochondrial Outer Membrane Protein Degradation"
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11:40 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Felicity Alcock (University of Oxford, United Kingdom)
"Analysing the Assembled Tat Translocase"
|
12:05 pm - 12:10 pm |
Discussion
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12:10 pm - 12:25 pm |
Cierra Spencer (San Francisco VA Medical Center / University of California, San Francisco, USA)
"Membrane Trafficking of the Accessory Sec Transport Substrate and Machinery"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Protein Transport in Health and Disease
Discussion Leader: Harris Bernstein (National Institutes of Health, USA)
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7:30 pm - 7:35 pm |
Introduction by Discussion Leader
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7:35 pm - 7:55 pm |
Han Remaut (VIB-VUB Center for Structural Biology, Vrije Universiteit Brussel, Belgium)
"Protein Transport in the Curli or Bacterial Amyloid Assembly Pathway"
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7:55 pm - 8:05 pm |
Discussion
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8:05 pm - 8:25 pm |
Meredith Morris (Clemson University, USA)
"Can We Learn New Tricks from an Old Dog? Glycosome Biogenesis in an Ancient Eukaryote"
|
8:25 pm - 8:35 pm |
Discussion
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8:35 pm - 8:55 pm |
Andrey Karamyshev (Texas Tech University Health Sciences Center, USA)
"Aberrant Secretory Proteins in Human Diseases"
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8:55 pm - 9:05 pm |
Discussion
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9:05 pm - 9:25 pm |
Renate Jansen (University of Groningen, The Netherlands)
"Targeting and Insertion of Pxa1, the Yeast Homologue of ALDP, a Peroxisomal ABC Transporter Important for Human Health"
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9:25 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Response of Protein Transport to Stress
Discussion Leader: Carla Koehler (University of California, Los Angeles, USA)
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9:00 am - 9:05 am |
Introduction by Discussion Leader
|
9:05 am - 9:30 am |
Cole Haynes (University of Massachusetts Medical School, USA)
"The Mitochondrial UPR and Mitochondrial Protein Import Efficiency"
|
9:30 am - 9:40 am |
Discussion
|
9:40 am - 10:05 am |
Linda Kenney (Mechanobiology Institute, National University of Singapore, Singapore)
"Type Three Secretion"
|
10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
|
10:45 am - 11:10 am |
Jude Przyborski (University Hospital Heidelberg, Germany)
"Malaria Parasites Co-Opt Human Hsp70 for Protein Translocation"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:40 am |
Christopher Stubenrauch (Monash University, Australia)
"The TAM: A Nanomachine Responsible for the Assembly of Complex Outer Membrane Proteins"
|
11:40 am - 11:45 am |
Discussion
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11:45 am - 12:05 pm |
Takuya Shiota (Organization for Promotion of Tenure Track, University of Miyazaki, Japan)
"Analysis of the Function of Beta-Barrel Assembly Machinery in the Bacteria by New Method EMM Assembly Assay"
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:25 pm |
Marco Catipovic (Harvard University, USA)
"Single Molecule Studies of the Bacterial Translocase SecA"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Systems/High-Throughput Approaches to Understanding Protein Transport and Organelle Biogenesis
Discussion Leader: Shu-Ou Shan (California Institute of Technology, USA)
|
7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
7:35 pm - 8:00 pm |
Sabrina Koch (University of Groningen, The Netherlands)
"Two Distinct Anionic Lipid Dependent Steps During Posttranslational Translocation"
|
8:00 pm - 8:10 pm |
Discussion
|
8:10 pm - 8:35 pm |
Carla Koehler (University of California, Los Angeles, USA)
"Small Molecule Modulators for Mitochondrial Protein Import"
|
8:35 pm - 8:45 pm |
Discussion
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8:45 pm - 9:00 pm |
Joseph Glavy (College of Pharmacy, University of Texas at Tyler, USA)
"Stabilizing Forces Holding the Nuclear Pore Ring Assembly"
|
9:00 pm - 9:05 pm |
Discussion
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9:05 pm - 9:25 pm |
Nadja Ernst (Massachusetts General Hospital / Harvard Medical School, USA)
"A High-Throughput Secretion Assay Reveals a Chaperone-Independent Type III Secretion Pathway"
|
9:25 pm - 9:30 pm |
Discussion
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Friday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am |
Departure
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