Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Complexity in Proteins
Discussion Leader: Erin Dueber (Genentech, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Karen Fleming (Johns Hopkins University, United States)
"Membrane Proteins Enter the Fold"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Wah Chiu (Stanford University, United States)
"Visualizing Tubulin Folding Intermediates"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Membrane Proteins
Discussion Leader: Karen Fleming (Johns Hopkins University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:40 am
Benoit Roux (University of Chicago, United States)
"Rare Conformational Transitions in Biomolecular Systems"
9:40 am - 9:50 am
Discussion
9:50 am - 10:25 am
Stephen Sligar (University of Illinois, United States)
"Nanodiscs Reveal the Structure and Function of Membrane Proteins"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 12:00 pm
Linda Columbus (University of Virginia, United States)
"Impact of Membrane(ish) Properties on Membrane Protein Structure and Dynamics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Erin Dueber (Genentech, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biologics and Drug Discovery
Discussion Leader: James Kranz (GreenLight Biosciences, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:15 pm
K. Dane Wittrup (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, United States)
"Engineering Binding Paratopes onto Cyclotide Scaffolds"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
John Karanicolas (Fox Chase Cancer Center, United States)
"Rescuing Destabilized Protein Mutants Using Small Molecules"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Protein Ensemble
Discussion Leader: Jeetain Mittal (Texas A&M University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:40 am
Nicolas Lux Fawzi (Brown University, United States)
"Using NMR Spectroscopy to See Protein Phase Separation with Atomic Detail"
9:40 am - 9:50 am
Discussion
9:50 am - 10:25 am
Ken Dill (Stony Brook University, SUNY, United States)
"Proteins as a Driver of Evolution and Origins of Life"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 12:00 pm
Vincent Hilser (Johns Hopkins University, United States)
"How Local Unfolding in Protein Ensembles Drives Adaptation and Metamorphic Behavior"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Aggregation and Phase Separation
Discussion Leaders: Shana Elbaum-Garfinkle (CUNY ASRC, United States)
7:30 pm - 8:00 pm
Jeetain Mittal (Texas A&M University, United States)
"Revealing Molecular Grammar Underlying Biomolecular Assemblies Using Computer Simulations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Robert Tycko (National Institutes of Health, United States)
"Millisecond Time-Resolved Solid-State NMR Studies of Protein Folding, Complex Formation, Amyloid Self-Assembly, and Related Processes"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Martin Blackledge (Institute of Structural Biology, CEA Grenoble, France)
"NMR Provides Unique Insight into the Functional Dynamics and Interactions of Intrinsically Disordered Proteins"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzymology
Discussion Leader: Giulia Palermo (University of California, Riverside, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:40 am
Emily Parker (Victoria University of Wellington, New Zealand)
"Evolved and Evolving Allosteric Regulation in the Biosynthesis Amino Acids"
9:40 am - 9:50 am
Discussion
9:50 am - 10:25 am
Elizabeth Komives (University of California San Diego, United States)
"Serine Protease Dynamics Revealed by NMR and Amide Exchange"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 12:00 pm
Lynn Kamerlin (Georgia Institute of Technology, United States)
"Loop Dynamics and the Evolution of Enzyme Activity"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Complex Proteins
Discussion Leader: Martin Blackledge (Institute of Structural Biology, CEA Grenoble, France)
7:30 pm - 8:00 pm
James Shorter (University of Pennsylvania, United States)
"Countering Deleterious Phase Transitions in Neurodegenerative Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Shana Elbaum-Garfinkle (Advanced Science Research Center, Graduate Center, CUNY, United States)
"Tunable Properties and Dynamics of Biomolecular Condensates"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Giulia Palermo (University of California, Riverside, United States)
"Dynamics and Mechanisms of CRISPR-Cas9 Through the Lens of Computational Methods"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Protein Complexes
Discussion Leader: Eva Nogales (University of California, Berkeley, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:40 am
Gabriela Schlau-Cohen (Massachusetts Institute of Technology, United States)
"Crossing the Membrane: Conformational Dynamics in Signal Transduction"
9:40 am - 9:50 am
Discussion
9:50 am - 10:25 am
Charles Brooks (University of Michigan, United States)
"Informing and Directing Biocatalyst Design Through Structure-Function Hypotheses from Ancestral Phylogenetic Reconstruction"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 12:00 pm
Martin Gruebele (University of Illinois at Urbana-Champaign, United States)
"Protein-Protein Dynamics in the Cell"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Thinking Big: Macromolecular Complexes
Discussion Leaders: Michael Harms (University of Oregon, United States) and Erin Dueber (Genentech, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Eva Nogales (University of California, Berkeley, United States)
"Molecular Mechanisms in the Regulation of the Gene Silencer PRC2"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Juli Feigon (University of California, Los Angeles, United States)
"Structural Biology of Telomerase and Interactions at Telomeres"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure