Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Recent Progress in Proteoglycan Biology
Discussion Leaders: Marian Young (National Institutes of Health, USA) and Renato Iozzo (Thomas Jefferson University, USA)
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7:40 pm - 8:20 pm |
Peter Seeberger (Max Planck Institute of Colloids and Interfaces, Germany)
"Genetic Defects Linking Proteoglycans and Glycosaminoglycans to Clinical Phenotypes and Tissue Pathologies"
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8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:40 pm |
Short Talk Selected from Poster Abstracts
|
8:40 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Short Talk Selected from Poster Abstracts
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Short Talk Selected from Poster Abstracts
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9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Short Talk Selected from Poster Abstracts
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9:25 pm - 9:30 pm |
Discussion
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Monday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Genetic Defects Linking Proteoglycans and Glycosaminoglycans to Clinical Phenotypes and Tissue Pathologies
Discussion Leaders: Thomas Wight (Benaroya Research Institute, USA) and Suneel Apte (Cleveland Clinic, USA)
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9:00 am - 9:20 am |
Fransiska Malfait (Center for Medical Genetics Ghent, Belgium)
"The "GAG-Linkeropathies": Rare Connective Tissue Disorders Caused by Genetic Defects in the Biosynthetic Enzymes for the Tetrasaccharide Linkerregion of Chondroitin-, Dermatan- and Heparan Sulfate"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
|
9:40 am - 9:45 am |
Discussion
|
9:45 am - 10:05 am |
Josephina Meester (University of Antwerp, Belgium)
"The Role of Biglycan in Thoracic Aortic Aneurysms and Dissections"
|
10:05 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Short Talk Selected from Poster Abstracts
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Eri Arikawa-Hirasawa (Juntendo University, Japan)
"Title Analyses of the Role of Heparan Sulfate Proteoglycan by 3D Tissue Construction Using iPS Cell-Derived Cells"
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11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Short Talk Selected from Poster Abstracts
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 12:05 pm |
Mark Febbraio (Monash University, Australia)
"The Proteoglycan Decorin is a Myokine that can Prevent Breast Cancer Progression"
|
12:05 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Catherine Merry (University of Nottingham, United Kingdom)
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4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Proteoglycans and Associated Molecules in Tissue Homeostasis and Disease
Discussion Leaders: Billy Hudson (Vanderbilt University, USA) and Nikos Karamanos (University of Patras, Greece)
|
7:30 pm - 7:50 pm |
Nicola Allen (Salk Institute for Biological Studies, USA)
"Role of Astrocyte-Expressed Glypicans in Neuronal Synapse Formation and Maturation"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:10 pm |
Short Talk Selected from Poster Abstracts
|
8:10 pm - 8:15 pm |
Discussion
|
8:15 pm - 8:35 pm |
Joseph Hippensteel (University of Colorado Anschutz Medical Campus, USA)
"Circulating Highly-Sulfated Chondroitin Sulfate as a Mediator of Sepsis-Associated Delirium"
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8:35 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Short Talk Selected from Poster Abstracts
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Anthony Day (University of Manchester, United Kingdom)
"Probing Protein-GAG Interactions (Some Old, Some New) in Lung Pathologies"
|
9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Proteoglycan Signaling
Discussion Leaders: Melanie Simpson (North Carolina State University, USA) and Jeffrey Esko (University of California, San Diego, USA)
|
9:00 am - 9:20 am |
Mythreye Karthikeyan (University of Alabama, USA)
"Betaglycan in Cancer: Benefits of Being Part Time"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
|
9:40 am - 9:45 am |
Discussion
|
9:45 am - 10:05 am |
Jorge Filmus (Sunnybrook Research Institute, Canada)
"Hedgehog and Wnt Signaling Mediate the Regulation of Gut Embryonic Development by Glypican-6 and Glypican-4"
|
10:05 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Short Talk Selected from Poster Abstracts
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Aaron Petrey (University of Utah, USA)
"Generation and Recognition of Hyaluronan Fragments in Thromboinflammatory disease"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Short Talk Selected from Poster Abstracts
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 12:05 pm |
Rashmin Savani (The University of Texas Southwestern Medical Center, USA)
"RHAMM as a Target in COVID-19"
|
12:05 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Proteoglycans in Regenerative Medicine
Discussion Leaders: Hideto Watanabe (Aichi Medical University, Japan) and John Whitelock (University of New South Wales, Australia)
|
7:30 pm - 7:50 pm |
Alyssa Panitch (University of California, Davis, USA)
"Promoting Cardiac Tissue Healing and Regeneration Using Peptide-Modified Glycosaminoglycans"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:10 pm |
Short Talk Selected from Poster Abstracts
|
8:10 pm - 8:15 pm |
Discussion
|
8:15 pm - 8:35 pm |
Tommaso Pizzorusso (University of Florence, Italy)
"Perienuronal Nets: Novel Tools to Investigate Their Role in the Brain"
|
8:35 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Short Talk Selected from Poster Abstracts
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Stephane Brezillon (CNRS UMR 7369 Université de Reims Champagne Ardenne, France)
"Differential MMP-14 Targeting by Lumican, Fibromodulin, Decorin and Biglycan Unraveled by In Silico Approach"
|
9:20 pm - 9:30 pm |
Discussion
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Proteoglycans and GAGs in Immuno-Oncology
Discussion Leaders: Karin Forsberg-Nilsson (Uppsala University, Sweden) and Stephen Hewitt (National Cancer Institute, NIH, USA)
|
9:00 am - 9:20 am |
Fotis Asimakopoulos (University of California, San Diego, USA)
"Stromal Proteoglycan Remodeling Controls Dendritic Cells and T-cell Inflammation in Tumors"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
|
9:40 am - 9:45 am |
Discussion
|
9:45 am - 10:05 am |
Mattias Belting (Lund University, Sweden)
"Extracellular Vesicle Uptake in the Stressed Tumor Niche: Opposite Roles for Heparan and Chondroitin Sulfate Proteoglycans"
|
10:05 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Short Talk Selected from Poster Abstracts
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Wantong Yao (The University of Texas MD Anderson Cancer Center, USA)
"Discovery of Syndecan1 as a Critical Player in Pancreatic Cancer"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Short Talk Selected from Poster Abstracts
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 12:05 pm |
Paul Timpson (Garvan Institute of Medical Research, Australia)
"Perlecan as a New Target for Combination Therapy in Pancreatic Cancer"
|
12:05 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
New Technologies to Define the Role of PGs and GAGs in Health and Disease
Discussion Leaders: Brooke Farrugia (University of Melbourne, Australia) and Vincent Hascall (Cleveland Clinic, USA)
|
7:30 pm - 7:50 pm |
Sylvie Ricard-Blum (Université Claude Bernard Lyon 1, France)
"Conformations and Interactions of Syndecans: the Role of Disorder at the Cell Surface"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:10 pm |
Short Talk Selected from Poster Abstracts
|
8:10 pm - 8:15 pm |
Discussion
|
8:15 pm - 8:35 pm |
Jamie Thompson (University of Nottingham, United Kingdom)
"Cutting Down on Sugars: Using CRISPR-cas9 and Stem Cells to Investigate Heparan Sulphate in Human Development"
|
8:35 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Short Talk Selected from Poster Abstracts
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Adam Hall (Wake Forest School of Medicine, USA)
"Sensitive Analysis of Hyaluronan Using Solid-State Nanopore Sensors"
|
9:20 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Development of New Drugs Targeting Proteoglycans
Discussion Leaders: Jin-Ping Li (Uppsala University, Sweden) and Ralph Sanderson (The University of Alabama at Birmingham, USA)
|
9:00 am - 9:20 am |
Jeremy Turnbull (University of Liverpool, United Kingdom)
"Next Generation Heparins and Mimetics for Alzheimers, Nerve Repair and Covid 19"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
|
9:40 am - 9:45 am |
Discussion
|
9:45 am - 10:05 am |
Nunzio Bottini (University of California, San Diego, USA)
"Targeting Proteoglycans for Rheumatoid Arthritis Therapy"
|
10:05 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Short Talk Selected from Poster Abstracts
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Jian Liu (University of North Carolina at Chapel Hill, USA)
"Design of Synthetic Heparan Sulfate with Anti-Inflammatory Properties"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Short Talk Selected from Poster Abstracts
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 12:05 pm |
Mitchell Ho (National Cancer Institute, NIH, USA)
"Glypicans as Emerging Targets for CAR T Cell Therapy in Solid Tumors"
|
12:05 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Matrix-Targeted Glycan Therapeutics in Clinical Trials
Discussion Leaders: Glenn Prestwich (Clear Solutions Biomedical, USA) and John Paderi (IHP Therapeutics, USA)
|
7:30 pm - 7:45 pm |
Li Peng (Palleon Pharmaceuticals, USA)
"Development and Engineering of Human Sialidase Neu2 for Degradation of Immunosuppressive Sialoglycans as a Novel Cancer Immunotherapeutic Approach"
|
7:45 pm - 7:50 pm |
Discussion
|
7:50 pm - 8:05 pm |
Sangeetha Srinivasan (Shasqi, Inc., USA)
"CAPAC Platform – First-in-Human Click Chemistry in Cancer Therapeutics: From Concept to Clinic"
|
8:05 pm - 8:10 pm |
Discussion
|
8:10 pm - 8:25 pm |
Mats Wahlgren (Karolinska Institutet, Sweden)
"Intra-Venous Heparinoid Treatment (Sevuparin) of Human Malaria Blocks Deformation and Invasion of the Red Blood Cell"
|
8:25 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:45 pm |
Denis Barritault (Otr3, France)
"Heparan Sulfates Mimetics RGTA Technology and Matrix Therapy: From Bench to Patients"
|
8:45 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:05 pm |
Thomas Kennedy (Tulane University, USA)
"Low Anticoagulant 2-O, 3-O Desulfated Heparin: From an Improbable Chance Meeting to an Inhibitor for RAGE, Alarmins and Chemokines in Humans Diseases"
|
9:05 pm - 9:10 pm |
Discussion
|
9:10 pm - 9:25 pm |
Abigail Pulsipher (GlycoMira Therapeutics, USA)
"Translational Investigations of Glycosaminoglycan-Based Therapeutics for Chronic Rhinosinusitis in Cystic Fibrosis"
|
9:25 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|