Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Chemical Editing of Proteoglycan Architecture
Discussion Leaders: Lorna Milne (School of Pharmacy, The University of Nottingham, United Kingdom) and Deepsing Syangtan (MIT, United States)
3:45 pm - 4:15 pm
Mia Huang (Scripps Research, United States)
"Chemical Editing of Proteoglycan Architecture"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteoglycan Regulation in Health and Disease
Discussion Leaders: Karina Dias Teixeira (University of Virginia, United States) and Meg Critcher (Scripps Research, United States)
7:30 pm - 7:45 pm
Kathryn Malpas (University of Manchester, United Kingdom)
"Characterisation of the Interactions of Recombinany Murine Chitinase-Like Proteins with Glycosaminoglycans"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Amulya Sreekumar (University of Pennsylvania, United States)
"Heparan Sulfate Proteoglycans Promote Residual Tumor Cell Survival and Breast Cancer Recurrence"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Fabian Gude (WWU Münster / UKM Institute of physiological chemistry and pathobiochemistry, Germany)
"Bivalent Heparan Sulfate Interactions Determine Hedgehog Morphogen Gradient Robustness and Range: A General Mechanism for Extracellular Protein Distribution?"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Anna Whitehead (Louisiana State University Health Sciences Center- New Orleans, United States)
"Myeloid Sulf Deletion and Immune Dysfunction in Multiple Sulfatase Deficiency"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Amrita Basu (University of Georgia, United States)
"TFCP2 is a Novel Transcriptional Regulator of Growth Factor Binding to 6-O Sulfated Heparan Sulfate"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Ryan Sullivan (University of Colorado/ Lab of Dr. Eric Schmidt, United States)
"The Impact of Aging on Sepsis-Related Endothelial Glycocalyx Degradation"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Structural Analysis, Technologies and Emerging Therapeutics
Discussion Leaders: Kimberly Alonge (University of Washington, United States) and Christophe Langouet-Astrie (University of Colorado Denver, Anshutz Medical Campus, United States)
9:00 am - 9:15 am
Margaret Downs (Boston University, United States)
"Alterations to the Extracellular Matrix of Anterior Cerebral Artery in Alzheimer’s Disease"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Max Urbanczyk (University Hospital Tübingen, Germany)
"Decorin Improves Pancreatic ß-cell Function and Regulates ECM Expression in vitro"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Anna Gray (University of Manchester, United Kingdom)
"High Resolution Intravital Imaging to Examine the Mouse Endothelial Glycocalyx"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Samreen Jatana (Cleveland Clinic Foundation, United States)
"Protective Effect of 35 kDa Molecular Weight Hyaluronan in Maintenance of the Epithelial Barrier in Colonic Organoids under Hyperglycemic Stress"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Zhangjie Wang (University of North Carolina at Chapel Hill, United States)
"Analysis of 3-O-sulfated Heparan Sulfate in Neurodegenerative Disease Using Isotopically Labeled Oligosaccharide Calibrants"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Jake Valeri (Department of Psychiatry -- University of Mississippi Medical Center, United States)
"Extracellular Matrix Abnormalities in Substance Use and Major Depressive Disorders"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Scientific Careers in Academia and Industry
Discussion Leaders: Mia Huang (Scripps Research, United States)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Scientific Careers in Academia and Industry
Alyssa Panitch (University of California, Davis, United States)
Joseph Hippensteel (University of Colorado Anschutz Medical Campus, United States)
Jian Liu (University of North Carolina, United States)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes