Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Globalization of Radioligand Therapy
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:00 pm
"Radiochemistry Miniaturization to Facilitate Increased Access to RLT"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Globalization of RPT, The Landscape Beyond North America and Europe"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"An Industry Perspective on the need to See It, Then Treat"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Do We Need to See It, Then Treat It? A Clinician's Perspective"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Strategies for Target Selection
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Criteria for RPT Drug Development: Target Selection, Validation, and Beyond"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Can AI Accelerate Target Identification?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Achieving the Potential of Conditionally Activated Therapeutics"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biomarkers of Patient Selection and Outcomes
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Stratifying and Monitoring Patient Response to PSMA RLT: Leveraging Existing Assays"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Emerging Biomarkers of RPT Response: Noninvasive Imaging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Multi-omics: Genomics, Epigenomics, and RPT"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Radiopharmaceutical Therapy and the Tumor Microenvironment
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Does the Tumor Ecosystem Support or Resist RPT?"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Is Stromal Ablation a Good Idea?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Targeting Cancer Stem Cells"
11:30 am - 11:40 am
Discussion
11:40 am - 12:10 pm
"Thoughtful Combination Strategies"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fact or Fiction: RPT as an Immune Activator
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Triggering and Sustaining Activation of the Cancer Immunity Cycle"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Friend or Foe: Mechanistic Underpinnings of Radiation-induced Immune"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Synergizing Radiotherapy with Immune Activation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Balancing Potency and Protection: Molecular Strategies for Optimizing RPT Dosing
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Discovery and Human Imaging Assessments of Miniprotein Radioconjugates Targeting Nectin-4 and B7-H3"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Strategies for Protecting the Kidneys"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:00 am
"Small versus Large Molecules: The Quest for the Optimal RLT Construct"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Appropriate Targets for RLT? High Selectivity vs. High Expression"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Optimizing Dosing Strategies: Dose, Frequency"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
From Concept to Clinic Translation: Defining Success Across the Discovery and Development Pipeline
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Bench to Bedside: The Development αvβ6 RPT"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"RPT Landscape: Lessons Learned"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Criteria for Next Generation RPT"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
From Receptor Biology to Precision Dosimetry
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"A Tribute to Sue O'Dorisio and her Pioneering Contributions to Radionuclide Theranostics in Pediatric and Adult Endocrine Tumors"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Beyond Receptor Expression: Target Biology and Its Impact on Radiopharmaceutical Therapy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"The Role of Dosimetry in the Advancement of Radiopharmaceuticals"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Torch® Monte Carlo-Based SPECT Recon: Enabling Faster, Accurate Dosimetry"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Is Dosimetry Needed for Clinical Radiopharmaceutical Therapies?"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovations in RPT: The Road Ahead
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Covalent Binders: An Approach to Enhancing Therapeutic Efficacy"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Pretargeting: The Good, The Bad, and the Lessons in Progress"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Reimagining RIT with Click-triggered Radioactivity Cleavage and Clearance from Blood"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure