| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Developmental Aspects of Hematopoiesis |
| Discussion Leader: Elaine Dzierzak (Erasmus) |
| 7:40 pm - 8:05 pm | Roger Patient (Oxford)
"Induction of hematopoiesis in early development" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Margaret Baron (Mt. Sinai)
"A Return to the Primitive" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Kyunghee Choi (Washington University)
"Pathways in Hematopoietic Development" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Elaine Dzierzak (Erasmus)
"AGM microenvironment in hematopoiesis" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Membrane-cytoskeletal protein interaction |
| Discussion Leader: Joseph Hoffman (Yale) |
| 9:00 am - 9:25 am | Velia Fowler (Scripts)
"The ortical actin cytoskeleton" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Athar Chishti (U. of Illinois/Chicago)
"Linkage of the Junctional Complex to the Membrane" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break / Group Photo |
| 10:30 am - 10:55 am | Phil Low (Purdue)
"Loop deletions in B3" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:25 am | Ron Dubreuil (U. Illinois)
"Unexpected complexity of the spectrin-membrane interaction" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Souvik Bhattacharjee (Northwestern)
"Virulence trafficking to the erythrocyte membrane" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:25 pm | Dominique Promeneur (Duke)
"Aquaglyceroporin channels and the intraerythrocytic stages
of the malaria parasite Plasmodium berghei" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Global Regulation of Gene Expression |
| Discussion Leader: Doug Engel (U of Michigan) |
| 7:30 pm - 7:55 pm | Keynote
Lecture: Frank Grosveld (Erasmus)
"The active chromatin hub" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Doug Higgs (Oxford)
"Alpha globin gene regulation" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Masi Yamamoto (Univ. Tsukuba, Tsukuba, Japan)
"Genetic Analysis of Mouse GATA-related Leukemia and Leukemic Stem Cells" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Doug Engel (U of Michigan)
"Role of TR2/4 in gamma globin regulation" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Transcription Factors |
| Discussion Leader: James Bieker (Mt. Sinai) |
| 9:00 am - 9:20 am | Michael Bender (U. Washington)
"Nuclear Localization control of transcription" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:50 am | Gerd Blobel (U. Penn)
"Mechanisms of gene repression by GATA-1" |
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:20 am | Coffee Break |
| 10:20 am - 10:40 am | Marella DeBrujn (Oxford)
"Transcriptional Regulation of Runx1 during Hematopoietic Stem Cell Emergence" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 11:10 am | Sjaak Phillipsen (Erasmus)
"Sp/Klf transcription factor family members in erythropoiesis" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Joyce Lloyd (Virginia Commonwealth U.)
"KLF proteins and erythropoiesis" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Deepa Manwani (Mt. Sinai)
"EKLF in MEP lineage decisions" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Cindy Leung (U. Chicago)
"Survivin in erythropoiesis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Control of Protein Diversity during erythropoiesis |
| Discussion Leader: Dave Bodine (NIH) |
| 7:30 pm - 7:50 pm | Frank Slack (Yale)
"MicroRNAs in development and cancer" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Dave Bodine (NIH)
"Mechanism of Red-Cell Specific Activation of the Ankyrin Promoter" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | John Conboy (LBL)
"Control by alternative splicing of the 4.1R gene" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Shu Huang (Harvard)
"Alternative promoters govern exon 2’/2 3’ splice site selection in protein 4.1R" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Eric Bouhassira (Einstein)
"Erythropoiesis during human ES cell differentiation" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling in Mature and Developing Red Cells |
| Discussion Leader: Phil Low (Purdue) |
| 9:00 am - 9:25 am | David Williams (Cincinnati Childrens)
"Rho GTPase in red cell development and membrane integrity" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Don Wojchowski (Maine Medical Center)
"New molecular regulators of stress erythropoiesis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Len Zon (Harvard)
"Pathways regulating hematopoietic development in the zebrafish" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Kay Macleod (U. Chicago)
"Role of Rb in stress erythropoiesis" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Vijay Sankaran (Harvard)
"Rb in erythropoiesis" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Marie- Christine Lecomte (INSERM)
"Spectrin acts as a regulator of the cell cycle" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Amelie Montel-hagen (INSERM)
"Erythrocyte GLUT1 expression and defective ascorbic acid synthesis" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Phenotypic transition during erythroid differentiation |
| Discussion Leader: Mohandas Narla (NY Blood Center) |
| 7:30 pm - 7:35 pm | Mohandas Narla (NY Blood Center)
"Introduction" |
| 7:35 pm - 8:00 pm | Joel Chasis (LBL-UCSF)
"Molecular events in EB island formation" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Mark Koury (Vanderbilt)
"Morphologic aspects of enucleation" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:00 pm | Manjit Hanspal (Tufts)
"Role of EMP in EB island formation" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Jim Palis (U. Rochester)
"Terminal Differentiation of Primitive Erythroid Cells" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 9:00 am - 12:30 pm | Red Cell Membrane Structure and dynamics |
| Discussion Leader: Vincent Marchesi (Yale University) |
| 9:00 am - 9:25 am | David Speicher (Wistar)
"Insights into the self-association domain of spectrin" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Dennis Discher (U. Penn.)
"Spectrin unfolding in health and disease-new approaches" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Xiuli An (NY Blood Center)
"Protein 4.1R based macrocomplex in red cell and its regulation" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:25 am | Anthony Baines (U. Kent)
"Evolution of mechanisms that allow red cell survival in circulation" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Graham Thomas (Penn State)
"Spectrin modulation of endocytosis and protein recycling" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:25 pm | David Golan (Harvard)
"Trans-membrane regulation of the spectrin skeleton by C3b" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Red Cell Disorders |
| Discussion Leader: Joel Chasis (LBL-UCSF) |
| 7:30 pm - 7:55 pm | Gary Kupfer (U. Virginia)
"Fanconi anemia: a signaling pathway of the DNA damage response" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Yves Colin (INSERM)
"Hereditary basis of Evan’s syndrome" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Stefan Karlsson (Lund U.)
"Ribosomal Defects in DBA" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Luanne Peters (Jackson Labs)
"Animal Models of Membrane Disorders" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
