Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Erythropoiesis and Red Blood Cell Research in Health and Disease
3:45 pm - 4:00 pm
"CRISPR Screens to Identify RBC Determinants for Malaria Infection"
4:00 pm - 4:05 pm
Discussion
4:05 pm - 4:25 pm
"Therapeutic Perspectives in Ineffective Erythropoiesis"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcriptional and Epigenetic Mechanisms Controlling Erythroid Commitment and Differentiation
7:30 pm - 7:40 pm
"Patient-Derived Bone Marrow Organoids Reveal Erythropoiesis Defects in Germline DDX41 and CHEK2 Mutations"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Tumor-Macrophage Crosstalk Promotes Tumor Growth and Disrupts Erythropoiesis During Bone Metastasis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Stag2-Directed Chromatin Remodeling Rnforces GATA1 Lineage Specificity During Bipotent to Unipotent Erythroid Switch"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Multiomic Profiling Reveals Targeting Pyrimidine Metabolism Can be Treated Myeloproliferative Neoplasms"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Lipid-Dependent Roles for SAMD14 in Erythropoiesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Irf5 Contributes to Imbalanced Blood Production During Aging Through Iron Sensing Within Erythromyeloblastic Islands"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Novel Short Isoform of Tensin1, eTNS1, is a Novel Regulator for Terminal Erythroid Differentiation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Commitment to Erythroid Lineage through PERK and IL4 during Stress Erythropoiesis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Red Blood Cell Biology Under Normal and Pathological Conditions, Novel Therapies and Diagnostic Tools
9:00 am - 9:10 am
"Host Plasma Membrane Calcium ATPase (PMCA4b) Variations Mediate Intraerythrocytic Redox Imbalance to Determine Artemisinin Sensitivity in Malaria."
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Red Blood Cell Passage Through Deformable Interendothelial Slits in the Spleen: Insights into Splenic Filtration and Hemodynamics"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Extracellular Vesicles from Plasmodium falciparum-Infected Red Blood Cells Cause Significant Alterations in Erythroid Differentiation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"A Role for DHODH-Mediated Ferroptosis Suppression in Erythroid Differentiation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Metabolic Regulation in Stress Erythropoiesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Identifying Novel Signaling Pathways in the Development of the Early Stress Erythropoiesis Niche."
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Forward Genetics CRISPR/Cas12a Screens in Progenitor Cells Reveal Human RBC Proteins Important for Malaria Parasite Invasion"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Suppression of Non-Canonical Autophagy Induces Endothelial Dysfunction and a Decrease in Endothelial Hemoglobin Subunit Alpha"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Career Pathways: A Panel for Early-Stage Red Blood Cell Scientists
1:30 pm - 1:40 pm
"Where Science Meets the Bedside: Bridging Research and Patient Impact"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
"Beyond the Resume: How Your Unique Path Fuels Career Success"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"How to Prepare for a Chalk Talk"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
"From Questions to Breakthroughs: Navigating the Academic Research Path"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes