| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 4:00 pm - 6:00 pm | Welcoming Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DIVERSITY AND EVOLUTION OF MECHANISMS FOR EDITING AND MODIFICATION |
| Discussion Leader: Michael Gray (Dalhousie University) |
| 7:30 pm - 7:40 pm | Welcome and opening remarks |
| 7:40 pm - 8:00 pm | Henri Grosjean (LEBS, CNRS, Gif-sur-Yvette)
"RNA Modification-Editing enzymes: the evolutionary point of view" |
| 8:00 pm - 8:25 pm | Brenda Bass (University of Utah)
"Adenosine deaminases that act on RNA: how inosines change behavior" |
| 8:25 pm - 8:50 pm | Stu Maxwell (North Carolina State University)
"Evolution of the Box C/D RNP: an ancient nucleotide modification machine essential for ribosome biogenesis" |
| 8:50 pm - 9:15 pm | Michael Neuberger (MRC Laboratory of Molecular Biology)
"DNA editing in immunity" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TARGET SITE SELECTION AND CATALYSIS - 1 |
| Discussion Leader: Maureen Hanson (Cornell University) |
| 9:00 am - 9:25 am | Jonatha Gott (Case Western Reserve University)
"Localization of cis-acting elements that direct editing in Physarum mitochondria" |
| 9:25 am - 9:50 am | Axel Brennicke (University of Ulm)
"Cis- and trans-factors in plant mitochondrial RNA editing" |
| 9:50 am - 10:15 am | Junichi Obokata (Nagoya University)
"Cis- and trans-acting factors for RNA editing in chloroplasts" |
| 10:15 am - 10:40 am | Juan Alfonzo (Ohio State University)
"Determinants of tRNA editing in Leishmania tarentolae" |
| 10:45 am - 11:15 am | Coffee Break |
| 11:15 am | Group Photo |
| 11:30 am - 11:55 am | Peter Beal (University of Utah)
"The chemical mechanism of RNA editing by adenosine deamination" |
| 11:55 am - 12:10 pm | Joakim Nasvall (Umea University)
"Two novel genes identified in the synthesis of uridine-5-oxyacetic acid:
The revised wobble hypothesis revisited" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOLOGICAL ROLES OF THE APOBEC PROTEINS |
| Discussion Leader: Nick Davidson (Washington University) |
| 7:30 pm - 7:55 pm | Nick Davidson (Washington University)
"Apobec-1 and ACF influence cellular proliferation and survival" |
| 7:55 pm - 8:20 pm | Michael Malim (King's College)
"Cytidine deamination and HIV" |
| 8:20 pm - 8:45 pm | Nathaniel Landau (Scripps Research Institute)
"HIV Vif: a retroviral defense against the innate immune system" |
| 8:45 pm - 9:10 pm | Reuben Harris (University of Minnesota)
"Retroviral- and retrotransposon restriction by APOBEC proteins" |
| 9:10 pm - 9:25 pm | Andrew Torelli (University of Rochester)
"Mutants of HIGM2 in relation to AID structure and function" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:15 am | TARGET SITE SELECTION AND CATALYSIS - 2 |
| Discussion Leader: Jonatha Gott (Case Western Reserve University) |
| 9:00 am - 9:25 am | Maureen Hanson (Cornell University)
"Chloroplast RNA editing in vitro and in vivo" |
| 9:25 am - 9:50 am | Barbara Sollner-Webb (Johns Hopkins University)
"Insights on trypanosome RNA editing through RNAi and biochemical analyses" |
| 9:50 am - 10:15 am | Greg Connell (University of Minnesota)
"Specificity of the Leishmania U-insertion reaction" |
| 10:15 am - 10:45 am | Coffee break |
| 10:45 am - 12:30 pm | REGULATION |
| Discussion Leader: Tom Meier (Albert Einstein College of Medicine) |
| 10:45 am - 11:10 am | Alex Huttenhofer (University of Innsbruck)
"A methylation guide C/D snoRNA inhibits ADAR2-mediated editing in the nucleolus" |
| 11:10 am - 11:35 am | Liam Keegan (Medical Research Council Human Genetics Unit)
"Post-transcriptional regulation of the ADAR genes" |
| 11:35 am - 12:00 pm | Harold Smith (University of Rochester)
"ACF post-translational modification in the regulation of apoB mRNA editing activity" |
| 12:00 pm - 12:25 pm | Steve Hajduk (Marine Biology Laboratory)
"Developmental regulation of RNA editing in African trypanosomes" |
| Hot topic |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CELLULAR TRAFFICKING AND NETWORKING |
| Discussion Leader: Harold Smith (University of Rochester) |
| 7:30 pm - 7:55 pm | Michael Terns (University of Georgia)
"Biogenesis and trafficking of telomerase" |
| 7:55 pm - 8:20 pm | Edouard Bertrand (Institut de Génétique Moléculaire de Montpellier)
"Intracellular trafficking of box C/D snoRNAs in human cells" |
| 8:20 pm - 8:45 pm | Gordon Carmichael (University of Connecticut Health Center)
"Characterization of nuclear proteins that connect RNA editing to heterochromatic gene silencing" |
| 8:45 pm - 9:10 pm | Marie Öhman (Stockholm University)
"Coordination of A to I editing and splicing by the transcription machinery" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MACROMOLECULAR MACHINES AND FUNCTIONAL INTERACTIONS |
| Discussion Leader: Eric Phizicky (University of Rochester) |
| 9:00 am - 9:25 am | John Woolford (Carnegie Mellon University)
"Genetic and proteomic analysis of the dynamics of ribosome assembly in eukaryotes" |
| 9:25 am - 9:50 am | Tamas Kiss (Laboratoire de Biologie Moléculaire Eucaryote du C.N.R.S)
"Nuclear organization of the human modification guide RNA machinery" |
| 9:50 am - 10:15 am | Tom Meier (Albert Einstein College of Medicine)
"Structure-function relationships in H/ACA ribonucleoprotein particles mediating RNA pseudouridylation" |
| 10:15 am - 10:45 am | Coffee break |
| 10:45 am - 11:00 am | Bruno Lapeyre (CRBM du CNRS)
"Breaking the snoRNA-guided methylation rule: Spb1p directs the formation of Gm2922, the putative tRNA docking site in the ribosome catalytic center, at a late processing stage" |
| 11:00 am - 11:25 am | Larry Simpson (UCLA)
"Characterization of proteins and complexes involved in U-insertion/deletion RNA editing" |
| 11:25 am - 11:50 am | Ken Stuart (Seattle Biomedical Research Institute)
"Functional interactions among proteins that catalyze RNA editing in trypanosomes" |
| 11:50 am - 12:05 pm | Jorge Cruz-Reyes (Texas A&M University)
"RNA editing and RNA/protein interactions in procyclic and bloodstream trypanosomes" |
| 12:05 pm - 12:20 pm | Donna Koslowsky (Michigan State University)
"The thermodynamics and kinetics of RNA interactions during RNA editing in trypanosomes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRUCTURAL BIOLOGY OF RNA AND PROTEINS |
| Discussion Leader: Juli Feigon (UCLA) |
| 7:30 pm - 7:55 pm | Juli Feigon (UCLA)
"Structural studies of H/ACA snoRNA" |
| 7:55 pm - 8:20 pm | Shigeyuki Yokoyama (University of Tokyo)
"Crystal structures of RNA modification enzymes" |
| 8:20 pm - 8:45 pm | Bernie Brown (Wake Forest University)
"Crystal structures of archaeal L7Ae multi-functional proteins indicate induced-fit interactions with the box C/D sRNAs and a revised model of Archaeal sRNP assembly" |
| 8:45 pm - 9:00 pm | Frederic Allain (ETH Zurich)
"Structure and specific RNA-binding of ADAR2 double-stranded RNA-binding domains" |
| 9:00 pm - 9:15 pm | Mark Macbeth (University of Utah)
"The crystal structure of the catalytic domain of hADAR2 at 1.7Å resolution" |
| 9:20 pm | Business Meeting |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | BIOLOGICAL AND BIOMEDICAL CONSEQUENCES |
| Discussion Leader: Mary O'Connell (MRC Human Genetics Unit) |
| 9:00 am - 9:25 am | Yi-Tao Yu (University of Rochester)
"Spliceosomal snRNA modification and its role in pre-mRNA splicing" |
| 9:25 am - 9:50 am | Tsutomo Suzuki (University of Tokyo)
"Biosynthesis of tRNA wobble modification and molecular pathogenesis of human diseases associated with RNA modification disorder" |
| 9:50 am - 10:15 am | Eric Phizicky (University of Rochester)
"tRNA editing during maturation of the 5' end of yeast tRNAHis" |
| 10:15 am - 10:45 am | Coffee break |
| 10:45 am - 11:10 am | Rob Reenan (University of Connecticut Health Center)
"Genetic reprogramming of the animal brain by ADARs" |
| 11:10 am - 11:35 am | Kazuko Nishikura (Wistar Institute)
"Stress-induced apoptosis associated with null mutation of ADAR1" |
| 11:35 am - 12:00 pm | Ron Emeson (Vanderbilt University)
"Targeted ablation of ADAR2 autoediting" |
| 12:00 pm - 12:25 pm | Peter Seeburg (Max-Planck Institute of Medical Research)
"The design and use of genetic mouse models to go after ADAR1 function" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IDENTIFICATION OF NEW ENZYMES AND SUBSTRATES |
| Discussion Leader: Rob Reenan (University of Connecticut Health Center) |
| 7:30 pm - 7:55 pm | Stefan Maas (Lehigh University)
"Novel in vivo targets for A-to-I editing: of miRNA precursors and other inverted repeat sequences" |
| 7:55 pm - 8:20 pm | Erez Levanon (Compugen, Ltd.)
"Genome-wide screening for RNA editing sites" |
| 8:20 pm - 8:45 pm | Valerie de Crecy-Lagard (University of Florida)
"Finding missing genes by comparative genomics: the tRNA modification goldmine" |
| 8:45 pm - 9:00 pm | Anthony Russell (Dalhousie University)
"Conserved and novel modifications and modification-guide snoRNAs in Euglena gracilis" |
| 9:00 pm - 9:15 pm | Maria Zago (Universty of British Columbia)
"The expanding world of small RNAs in the archaeon Sulfolobus solfataricus" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
