Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Conservation and Evolution in the Biology of tRNA Modifications
Discussion Leaders: Dan Bar Yaacov (Morgridge Institute for Research, University of Wisconsin-Madison, USA) and Anna Ovcharenko (Institute of Biochemistry, University of Münster, Germany)
3:15 pm - 3:45 pm
Eric Phizicky (University of Rochester School of Medicine, USA)
"Conservation and Evolution in the Biology of tRNA Modifications"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Function and Mechanism of Nucleic Acids Modifications
Discussion Leaders: Joseph Smith (State University of New York at Buffalo, USA) and Roni Haas (Technion - Israel Institute of Technology, Israel)
5:30 pm - 5:40 pm
Satoshi Kimura (Brigham and Women's Hospital, USA)
"The RNA Degradosome Promotes tRNA Qualilty Control Through Clearance of Hypomodified tRNA"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Qin Li (Stanford University, USA)
"Genetic Mapping of A-to-I RNA Editing in Human Tissues Links Population Variation and Autoimmune Disease"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Eshwar Meduri (University of Cambridge, United Kingdom)
"RNA Editing Landscape Demonstrates Reduced Editing in Acute Myeloid Leukemia"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Aikaterini Gatsiou (Newcastle University, United Kingdom)
"The RNA Editor, ADAR2, Is Required for Leukocyte Trafficking to Inflamed Tissues"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Tuangtong Vongpipatana (Osaka University, Japan)
"Loss of ADAR1 Induces Severe Apoptosis by Preventing the Expression of T Cell Receptors During Early Stage of T Cell Development in Mice"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Riccardo Pecori (German Cancer Research Center (DKFZ), Germany)
"Epitranscriptome: A New Modification in mRNA to Add to the List"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Yifeng Yuan (University of Florida, USA)
"Discovery of Novel Bacterial Queuine Salvage Enzymes and Pathways in Human Pathogens"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Lai Wong (University of Saskatchewan, Canada)
"Biochemical Characterization of the Human Cytidine Deaminase APOBEC1"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
From Mechanism to Cutting Edge Nucleic Acids Technologies
Discussion Leaders: Pedro Costa Cruz (Osaka University, Japan) and Valeriana Cesarini (Ospedale Pediatrico Bambino Gesù, Italy)
9:00 am - 9:10 am
Elizabeth Wadsworth (University of Edinburgh, United Kingdom)
"RNA Editing Within the Trypanosome Mitochondria"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Alexa McIntyre (Weill Cornell Medicine, USA)
"Re-Evaluating the Detection of Dynamic Changes in m6A in mRNA Through Immunoprecipitation-Based Sequencing"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Tobias Merkle (University of Tübingen, Germany)
"Harnessing Endogenous ADARs for Transcript Repair"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
SeHee Park (University of California, Davis, USA)
"Analyzing Structure and Function of Human ADAR1 Catalytic Domain Through Cysteine Library Screening"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
John Sinnamon (Vollum Institute, Oregon Health and Science University, USA)
"Targeted Editing of Mecp2 RNA in a Mouse Model of Rett Syndrome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Tewoderos Ayele (Emory University, USA)
"Fluorescent Labeling of mRNA Using Self-Alkylating Ribozymes"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Justin Thomas (National Cancer Institute, NIH, USA)
"Chemistry to Discover and Decode RNA Acetylation"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Christopher Wilson (Broad Institute of MIT and Harvard, USA)
"Expanding the Scope of Base Editing: Programmable RNA Modification"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Diverse Career Pathways for PhDs
Discussion Leaders: Leanna Monteleone (University of California, Davis, USA) and Andrew Watkins (Stanford University, USA)
1:30 pm - 2:30 pm
Panel Discussion
Diverse Career Pathways for PhDs
Edward Miracco (Moderna, Inc., USA)
Alyson Weidmann (American Chemical Society, USA)
Eric Phizicky (University of Rochester School of Medicine, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
