Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
RNA Folding and Structure
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Learning and Applying the Language of RNA Tertiary Interactions: Lessons from High Resolution RNA Structures"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"From Descriptive to Predictive Understanding: The RNA Reconstitution Model"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"The Multiple Flavors of GoU Pairs"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"RNA Self-Assembly from 5' to 3"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Ribosome: The Cornerstone for Creating Novel RNA Nanostructures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Construction of 3D and 4D RNA Nanostructures for Applications in Medical and Material Science"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Structures, Dynamics and Metal Ion Binding in Prohead RNA"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
"Understanding Immunogenic Properties of Nucleic Acid Nanoparticles"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Versatile Kit of Robust Nanoshapes from RNA and DNA Modules"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Nucleic Acid Nano-Scaffolds Designed from Flexible Tetra-U/T Helix Linking Module"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Homooligomeric Self-Assembly Structures Based on a Single RNA Tile"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acid Modeling and Computation
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"A Model for DNA Structure Kinetics Prediction with Arrhenius Rates"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"RNA Nanostructures: Integrating Computation with Experiments"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Computer-Aided Design of Cotranscriptionally-Folding RNA Origami"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Computational Protocol for Ligand Docking to RNA Can Aid in the Design of Ligand-Dependent Nanostructures"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"RNA-Cleaving DNA Machines and Logic Gates for Gene Therapy"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biological RNA Nanoparticles
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Biological Functions and Methods of Detection of Large Oncosomes in Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Deconvolution Analysis of Small RNAseq Data from exRNAs Reveals Multiple Carrier Subclasses"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Functional Role of Exosomal DNA and RNA in Cancer"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Molecular Crowding Regulates RNA Phase Separations in Repeat Expansion Disorders"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Self-Assembled Nucleic Acid-Protein-Lipid Devices for Bioimaging and Drug Delivery"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Human RNA Analysis Using a New Reference Transcriptome and Computational Framework"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Exosome Biogenesis at Plasma and Endosome Membranes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acid Based Sensors and Devices
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Liquid Biopsy on a Chip: Circulating Tumor Exosomes' Lineage Tracing Using NanoDLD Chip Technology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Miniaturized Devices for Nucleic Acid Detection: Robust Sensors for Point-of-Care Applications"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Modular Cell-Internalizing Aptamer Nanostructures for Targeted Delivery of Large Functional RNAs"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Design and Calibration of a Nanoscale Instrument for Dynamic Measurements of Nucleic Acid Bending"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Movers and Shakers: How to Accelerate Nucleic Acid Based Devices"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthetic and Biological Nucleic Acid Based Nanotherapeutics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Challenges and Opportunities for Engineering Extracellular Vesicles as Therapeutic Delivery Vehicles"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Extracellular Vesicles as Senotherapeutics for Extending Healthspan"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Universal Synthetic Technique for Nucleic Acid-Based Nanodetectors and Carrier-Free siRNA Delivery Systems"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Genetically Encoding Functional RNA Origami: Anti-Coagulants"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Heterochiral DNA Circuitry: Interfacing Mirror-Image DNA with Endogenous Nucleic Acids in Living Cells"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Towards Biomarkers for CNS Injuries and Neurodegenerative Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Developmental Path of MSC-EV Therapeutics from Preclinical to Clinical Studies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Extracellular RNA Based Diagnostics
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Extracellular Vesicle-Associated Biomarker Discovery in Liquid Biopsies"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Salivaomics, ExRNA and Liquid Biopsy"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"De Novo -Designed Ultra-Specific Riboregulators for Gene Regulation and Low Cost Paper-Based Diagnostics"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Ligand-Guided Selection (LIGS): A SELEX Variant to Develop Nucleic Acid Aptamers Against Cell-Surface Markers"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Current State of Clinical Exosome Based Biomarkers"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Molecular Systems Engineering with DNA"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Amphiphilic DNA Nanostructures: Self-Assembly and Biological Properties"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Polymers and Proteins in DNA Nanostructures"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Recreating Complex Biochemical Mechanisms Using DNA: From Fundamentals to Applications"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Using DNA Origami to Reveal Spatial Effects in Biology"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Programming 3D Nanoscale Architectures"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"RNA Aptamers as Genetic Control Devices: The Potential of Riboswitches as Synthetic Elements for Regulating Gene Expression"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Using RNA to Fuel Dynamic Self-Assembly"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"RNA Origami-Based Sensors and Devices In Vivo "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"sxRNA: Controlling the Expression of a Therapeutic mRNA Based on the Unique microRNA Profile of a Cell"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Small Molecule Activated gRNAs Enable High-Throughput and Multiplex Genome Editing in E. coli by Cas9"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure