Understanding Development, Function and Regeneration of Secretory Tissues: Novel Signaling Pathways and Approaches to Treat Exocrine Disorders

February 19 - 24, 2017

Chairs Gary A. Weisman and Catherine E. Ovitt

Vice Chairs Sarah M. Knox and Stefan Ruhl

Hotel Galvez

2024 Seawall Boulevard

Galveston, TX, US

Venue and Travel Information

Conference Description

The Gordon Research Conference (GRC) on Salivary Glands and Exocrine Biology will include sessions on exocrine gland development, regenerative approaches, functional relevance of salivary proteins, membrane functions in exocrine glands, understanding the etiology of autoimmune disease, targeting inflammation to retard disease pathogenesis and current topics in cell biology of exocrine glands. Invited speakers for the GRC will include eminent scientists from academia, industry and government and talks will include both senior and junior scientists from diverse fields who will present unpublished research findings on subjects of greatest interest to the field. This GRC will include a Graduate Research Seminar (GRS) to be held just prior to the GRC that will invite only speakers who are graduate students and postdoctoral associates in a wide variety of laboratories worldwide. In addition, poster sessions will be held daily at the GRC and GRS to enable all attendees to present and discuss their data in an open forum. The overall goal of the GRC and GRS will be to foster scientific exchanges and engender research collaborations in disciplines that are viewed as having a major impact on the development of novel strategies to improve human health. Specific Aims include: 1) to present a program of topical interest to attendees in a pleasant setting where they will have opportunities to present unpublished findings before a knowledgeable audience and engage in a wide range of critical research discussions; 2) to offer for the first time, a GRS to be attended by graduate students and postdoctoral associates who will present their novel research findings before an audience of their peers and; 3) to emphasize presentations on state-of-the-art methodologies of interest to the exocrine biology field towards the goal of developing innovative approaches to the improvement of human health by preventing disorders of secretory organs.

Related Meeting

This GRC will be held in conjunction with the "Salivary Glands and Exocrine Biology (GRS)" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Frontiers in Tissue Engineering Discussion Leaders: Gary Weisman (University of Missouri, USA) and Catherine Ovitt (University of Rochester, USA)
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 8:30 pm	David Mooney (John A. Paulson School of Engineering and Applied Sciences, Harvard University, USA) "Improving Stem Cell Therapeutics with Mechanobiology"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	Linda Griffith (Massachusetts Institute of Technology, USA) "Decoding Epithelial-Stromal Cross Talk with Synthetic Extracellular Matrix"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Exocrine Gland Development Discussion Leaders: Deborah Andrew (Johns Hopkins School of Medicine, USA) and Matthew Hoffman (National Institute of Dental and Craniofacial Research, NIH, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Helen Makarenkova (The Scripps Research Institute, USA) "The Dynamics of Murine Lacrimal Gland Stem/Progenitor Cells During Development, Homeostasis and Regeneration"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Lisa Sandell (University of Louisville, USA) "Signaling by the Vitamin A Derivative Retinoic Acid Regulates Development of Submandibular Salivary Epithelium"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Selected from Poster Abstracts: Aaron Mattingly (University of California, San Francisco, USA) "Neuregulin-1/ERBB3 Signaling Is Essential for Mouse Salivary Gland Development and Acinar Cell Formation"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Selected from Poster Abstracts: Rose-Anne Romano (State University of New York at Buffalo, USA) "Chromatin Fingerprinting of Enhancers and Super-Enhancers in the Control of Cell Fate and Identity in the Salivary Gland"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Abigail Tucker (King's College London, United Kingdom) "Fgf10 and Sox9 Interactions in Developing Salivary Glands"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Kenneth Yamada (National Institute of Dental and Craniofacial Research, NIH, USA) "3D Dynamics of Cells and Matrix in Branching Morphogenesis"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: Akiko Shitara (National Institutes of Health, USA) "Cdc42 Is Required for the Maintenance and Formation of Apical Lumens in Tubular Organs"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Bob Varelas (Boston University School of Medicine, USA) "The Hippo Pathway Effector YAP Is an Essential Regulator of Submandibular Gland Ductal Progenitor Patterning"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Emerging Concepts in Regenerative Medicine Discussion Leaders: Darlene Dartt (Schepens Eye Research Institute, Harvard Medical School, USA) and Mary Farach-Carson (University of Texas Health Science Center at Houston, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	Quynh-Thu Le (Stanford University, USA) "Activating the ALDH3 Pathway to Mitigate Radiation-Related Xerostomia"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	Driss Zoukhri (Tufts University, USA) "Mechanisms of Lacrimal Gland Repair"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	Danielle Benoit (University of Rochester, USA) "Tunable Hydrogel Microenvironments to Study Salivary Gland Cell Phenotype and Function"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	Melinda Larsen (University at Albany, SUNY, USA) "From Developmental Mechanisms to Regenerative Strategies"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Functional Relevance of Mucins and Salivary Proteins Discussion Leaders: Mary Reyland (University of Colorado Denver, USA) and Stefan Ruhl (University at Buffalo, SUNY, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Gordon Proctor (King's College London, United Kingdom) "Salivary Mucin Interaction with Mucosal Surfaces"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Paul Breslin (Rutgers University, USA) "The Role of Salivary Amylase in Taste and Regulatory Physiology"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Selected from Poster Abstracts: Joao Ferreira (National University of Singapore, Singapore) "Three-Dimensional Bioprinting Nanotechnologies for the Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Selected from Poster Abstracts: Omer Gokcumen (State University of New York at Buffalo, USA) "Archaic Hominin Introgression and Microbial Interactions Shaped Extant Salivary MUC7 Variants in Modern Humans"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Eva Helmerhorst (Boston University, USA) "Oral Microbe-Derived Gluten-Degrading Proteases"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Walter Siqueira (University of Western Ontario, Canada) "The Use of Nanotechnology on Salivary Proteins for the Prevention and Treatment of Oral Diseases"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: Michael Passineau (Allegheny Health Network, USA) "Activation of AQP1 in a Human Cell Line Targeted Epigenetic Editing"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Sarah Pringle (University of Groningen, The Netherlands) "Exhaustion of Salivary Gland Stem Cells Causes Hyposalivation in Primary Sjögren's Syndrome"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Membrane Functions in Exocrine Glands Discussion Leaders: Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, USA) and Brij Singh (University of North Dakota, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	Roberto Weigert (National Cancer Institute, NIH, USA) "Molecular Mechanisms of Membrane Remodeling During Regulated Exocytosis in Live Animals"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	Sarah Hamm-Alvarez (Keck School of Medicine, University of Southern California, USA) "Influence of Rab Proteins on Protein Secretion Profiles in Lacrimal Gland"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	David Yule (University of Rochester, USA) "Ca²⁺ Signaling Through Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	Shmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, USA) "Fix the Duct, Fix the Acini: CFTR and Sjögren's Syndrome"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Understanding the Etiology of Autoimmune Disease: From Mice to Humans Discussion Leaders: Ammon Peck (University of Florida, USA) and Julian Ambrus (School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Markus Hardt (Forsyth Institute, USA) "Proteolytic Profiles Associated with Sjögren's Syndrome"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Rachel Ettinger (MedImmune, USA) "Sjögren's Syndrome Arises Due to Early-Life Immune Dysregulation"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Selected from Poster Abstracts: A. Darise Farris (Oklahoma Medical Research Foundation, USA) "From Salivary Gland Lymphocyte Receptors to Salivary Gland Antigen Identification in Sjögren's Syndrome"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Selected from Poster Abstracts: David Ann (Beckman Research Institute, City of Hope, USA) "Autophagy Provides Asparagine to Promote Oncogenic KRAS-Driven Salivary Gland Progression"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Umesh Deshmukh (Oklahoma Medical Research Foundation, USA) "Microbes, Innate Immunity and the Salivary Gland"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Jay Chiorini (National Institute of Dental and Craniofacial Research, NIH, USA) "The Role of Epigenetics in Salivary Gland Dysfunction"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: Jill Kramer (State University of New York at Buffalo, USA) "MyD88 Deficiency Mitigates the Severity of Primary Sjögren's Syndrome"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Cuong Nguyen (University of Florida, USA) "Single-Cell Microengraving Analysis Reveals a Restricted and Sexual Dimorphic T Cell Receptor Repertoire of Interferon-γ and Interleukin-17A Producing T Cells in the Salivary Gland of Sjögren's Syndrome"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Targeting Inflammation to Retard Disease Pathogenesis Discussion Leaders: Maria Kukuruzinska (Boston University, USA) and David Ann (Beckman Research Institute, City of Hope, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	Marco Colonna (Washington University School of Medicine, USA) "The Role of TGFβ in the Development and Function of Salivary Gland Innate Lymphoid Cells"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	Yuka Kanno (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA) "Lymphocyte Genes, Genomes and New Drugs"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	Helen Braley-Mullen (University of Missouri, USA) "NOD.H-2h4 Mouse Mutants Provide Robust Models for Defining Mechanisms and Targeting Inflammation in Sjögren's Syndrome"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	Kirsten Limesand (University of Arizona, USA) "Signaling Mechanisms Involved in Radiation-Induced Chronic Loss of Function"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Mechanisms of Exocrine Gland Repair and Regeneration Discussion Leaders: Isabelle Lombaert (University of Michigan, USA) and Rob Coppes (University Medical Center Groningen, The Netherlands)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Matthias Hebrok (University of California, San Francisco, USA) "Dedifferentiation and Transformation of Pancreatic Exocrine Cells"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Stephen Konieczny (Purdue University, USA) "Clearing the MIST: Deciphering New Transcriptional Networks that Govern Secretory Throughput and the Unfolded Protein Response"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Selected from Poster Abstracts: Kimberly Jasmer-McDonald (University of Missouri, USA) "Exploring the Role of P2Y₂ Nucleotide Receptors in a Novel Autoimmune Mouse Model of Sjögren's Syndrome"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Selected from Poster Abstracts: Pei-Lun Weng (University of Rochester Medical Center, USA) "Lineage Tracing of Keratin 5 and Axin 2-Positive Cells in Adult Salivary Gland Shows No Contribution to Acinar Cells"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Jason Mills (Washington University School of Medicine in St. Louis, USA) "How Cells Scale Their Secretory Apparatus in Homeostasis and Cancer"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Jonathan Axelrod (Hadassah Medical Center, Hebrew University of Jerusalem, Israel) "Senescence-Mediated Loss of Salivary Gland Function: Is It the End of the Road?"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: Sten Wie (University of Colorado Anschutz Medical Campus, USA) "Inhibition of PKC Delta Confers Radioprotection to the Salivary Gland"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Danielle Wu (Rice University, USA) "Differentiation of Salivary Human Stem/Progenitor Cell Pedigrees in Bioactive 3D Hydrogels"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Clinical Trials for Sjögren's Syndrome Discussion Leaders: Sarah Knox (University of California, San Francisco, USA) and David Wong (UCLA School of Dentistry, USA)
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:30 pm	Robert Fox (Scripps Memorial Hospital and Research Foundation, USA) "Management of Sjögren's Syndrome: Where Do We Go from Here?"
8:30 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	General Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure