Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Systems Biology and Stem Cells: From Aging to Cancer
Discussion Leaders: Stefan Ruhl (University at Buffalo, SUNY, United States) and Sarah Knox (University of California, San Francisco, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
J. Silvio Gutkind (University of California, San Diego, United States)
"Understanding Oral Cancer at the Single Cell Level: Opportunities for Novel Multimodal Immunotherapies"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Xin Sun (University of California,San Diego, United States)
"From One Branching Organ to Another: Insights from the Lung"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Virus Infection of The Salivary Glands
Discussion Leaders: Jennifer Webster-Cyriaque (NIH/NIDCR, United States) and Qing Yu (The Forsyth Institute, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Nihal Altan-Bonnet (National Institutes of Health, United States)
"Enteric Virus Infect Salivary Glands"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Kevin Matthew Byrd (ADA Science & Research Institute, United States)
"COVD-19 and The Oral Axis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
José Maldonado-Ortiz (HealthPartners Institute, United States)
"Hepatitis C Virus Antiviral Therapy Reduces Infection Associated Salivary Gland Dysfunction"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Wendy Maury (University of Iowa, United States)
"SARS in the Lung"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Nao Gojo (Osaka University Graduate School of Dentistry, Japan)
"Analysis of the Mechanism in SARS-CoV-2 Infection via Oral and Nasal Cavity"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Lucas Woods (University of Missouri, United States)
"P2Y2 Nucleotide Receptors Modulate SARS-CoV-2 Cell Entry"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Shikha Jain (State University of New York at Buffalo, United States)
"Comparative Analysis of Saliva Proteomes of Humans and Non-Human Primates"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
James Kenney (University at Albany, United States)
"Epithelial Plasticity Following Salivary Gland Injury"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Belinda Hauser (NIDCR/NIH, United States) and Melinda Larsen (University at Albany, SUNY, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Salivary Protein Secretion and Glycobiology
Discussion Leaders: Walter Siqueira (University of Saskatchewan, Canada) and Marcelo Catalan (Universidad Austral de Chile, Chile)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Omer Gokcumen (University at Buffalo, SUNY, United States)
"Origins of Proteins Intrinsic to Human Saliva"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Malin Johansson (University of Gothenburg, Sweden)
"Mucus Protection of Epithelial Surfaces"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Anwesha Sarkar (University of Leeds, United Kingdom)
"Self-assembly of Salivary Proteins: What Do We Know So Far?"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Liping Zhang (NIDCR/NIH, United States)
"Regulated Packaging of Mucins in Secretory Granules of Drosophila Salivary Glands"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Immune System: Sjögren’s Disease Pathogenesis
Discussion Leaders: Umesh Deshmukh (Oklahoma Medical Research Foundation, United States) and Shmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Michele Bombardiere (QMUL, United Kingdom)
"Regulation and Therapeutic Targeting of Ectopic Germinal Centers in Sjögren’s Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Jill Kramer (University at Buffalo, SUNY, United States)
"Understanding Tissue-Specific Myd88 Activation in Sjögren’s Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Kai-Ting Huang (University of Rochester, United States)
"Alteration in stimulus-secretion coupling in a model of the early stages of Sjögren’s syndrome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Gary Weisman (University of Missouri, United States)
"Inflammatory Responses Mediated by P2 Receptors in Salivary Glands"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Stefan Feske (New York University, United States)
"Store-Operated Calcium Entry in Regulatory T Cells is Required to Prevent Sjogren’s Syndrome-like Disease in Mice"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Sonia Elder (University of Edinburgh, United Kingdom)
"Macrophages Interact with KRT14+ Progenitor Cells to Drive Salivary Gland Regeneration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yu Yin (Rice University / UT Health Science Center at Houston, United States)
"Additive 3D Bioprinting of Hydrogels for Salivary Tissue Engineering"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Siva V (Stanford University, United States)
"Hedgehog Signaling acts via Mesenchyme to Orchestrate Salivary Gland Homeostasis and Regeneration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Salivary Gland Regeneration and Tissue Repair: From Cells to Organs
Discussion Leaders: Mary Farach-Carson (University of Texas Health Science Center at Houston, United States) and Marit Aure (NIDCR, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Danielle Benoit (University of Oregon, United States)
"Microphysiological Systems to Engineer Extracellular Matrices for Salivary Gland Regeneration"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Fei Liu (Texas A&M University Health Science Center, United States)
"Immune Cells and Regeneration"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Jun Wu (University of Texas Southwestern Medical Center, United States)
"Stem Cells and Interspecies Organogenesis"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Sarah Knox (University of California, San Francisco, United States)
"(Re)Generation of Glandular Organs Takes Nerve"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Use of Emerging Technologies in Salivary Glands
Discussion Leaders: David Yule (University of Rochester, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Nagarajan (Raj) Kannan (Mayo Clinic, United States)
"Cellular DNA Barcoding to Clonally Track Heterogeneous Growth Responses of Transplantable Epithelial Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Kirsten Limesand (University of Arizona, United States)
"Integrative Transcriptomic and Metabolomic Network Analysis Reveals Pathways Involved in Radiation-induced Salivary Gland Dysfunction"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Randy Kimple (University of Wisconsin, United States)
"Results of a Pilot Study of Autologous, Cryopreserved, MSC(M) for the Treatment of Radiation-Induced Xerostomia"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Rose-Anne Romano (State University of New York at Buffalo, United States)
"Spitting out New Transcriptomic Circuitries in the Salivary Gland One Cell At a Time"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
John Lueck (University of Rochester School of Medicine and Dentistry, United States)
"Development of Engineered Transfer RNAs as Therapeutics for Nonsense-Associated Diseases"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Davide Cinat (University Medical Center Groningen, The Netherlands)
"Single Cell Transcriptomic Profiling of Salivary Gland Organoids Reveals a Differential stem/progenitor Cell Response to Photon Versus Proton Irradiation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Joao Ferreira (Chulalongkorn University Faculty of Dentistry, Thailand)
"Combining Plant Molecular Farming Cues with Tuned Hydrogels for Improving Biofabrication of Salivary Gland Epithelial Organoids"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jianlong Li (University of California, San Francisco, United States)
"Long-term Functional Regeneration of Radiation-Damaged Salivary Glands Through Delivery of a Neurogenic Hydrogel"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in the Clinic: New Therapies for Exocrine Gland Dysfunction
Discussion Leaders: Alan Baer (Johns Hopkins University, United States) and Brij Singh (University of Texas Health Science Center at San Antonio, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Rob Coppes (University Medical Center Groningen, The Netherlands)
"Autologous Transplantation of Submandibular Gland Organoid Derived Cells to Ameliorate Xerostomia After Radiotherapy"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Michael Passineau (MeiraGTx, United States)
"Preliminary Results from Phase 1 Trials of AAV2-hAQP1 Gene Therapy in Radiation-Induced Xerostomia"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Blake Warner (National Institute of Dental and Craniofacial Research, NIH, United States)
"Heterogeneity of Sjögren’s Disease Patients-Opportunities for Precision Medicine"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Kathy Sivils (Janssen, United States)
"Targeting Autoantibody Reduction as a Novel Therapeutic Approach in Sjogren's"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genomics and Biomarkers of Exocrine Gland Diseases
Discussion Leaders: Chris Lessard (Oklahoma Medical Research Foundation, United States) and Cuong Nguyen (University of Florida, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Darise Farris (Oklahoma Medical Research Foundation, United States)
"What is Genomics Teaching us About Salivary Gland T-Cells in Sjögren’s Disease?"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Kai Kessenbrock (University of California, Irvine, United States)
"Human Breast Cell Atlas Project"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Eiko Yamada (NIDCR, United States)
"JAK/STAT Blockade Corrects IFN Driven Inflammation and Epithelial Dysfunction"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Caroline Shiboski (University of California San Francisco, United States)
"Preliminary Omics Analyses in the Sjögren’s International Collaborative Clinical Alliance"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Kyle Gaulton (University of California, San Diego, United States)
"Genomics in Exocrine Tissues"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jacqueline Mays (National Institutes of Health, National Institute of Dental and Craciofacial Research, United States)
"The Salivary Gland-Immune Cell Interactome in Human Chronic Graft Versus Host Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Theresa Wrynn (University at Buffalo, United States)
"Comprehensive Analysis of Cell-Cell Communication Patterns in the Developing Salivary Gland Using scRNA-seq Datasets"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Helen Makarenkova (The Scripps Research Institute, United States)
"Single-Cell Analysis Reveals Unique and Common Features in the Lacrimal and Submandibular Gland Cell Types"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Resolution of Inflammation
Discussion Leaders: Isabelle Lombaert (University of Michigan, United States) and Gordon Proctor (King's College London, United Kingdom)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:40 pm
Charles Serhan (Harvard University, United States)
"Resolvins: Pro-resolving Mediators and Mechanisms in Inflammation & Infection"
8:40 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
