Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cell Motility and Invasion: Signals From the Cell-ECM Interphase
Discussion Leader: Kathleen Green (Northwestern University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Erik Sahai (The Francis Crick Institute, United Kingdom)
"Adhesion-Regulated Pulsatile MAP Kinase Signaling Enables Resistance to Targeted Cancer Therapies"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Valerie Weaver (University of California, San Francisco, United States)
"Interplay Between Tissue Tension, Inflammation and Tumor Initiation and Progression"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Adhesion: Assembly and Signaling Platforms
Discussion Leader: Martijn Gloerich (University Medical Center Utrecht, The Netherlands)
9:00 am - 9:25 am
Kris DeMali (Carver College of Medicine, University of Iowa, United States)
"Mechanisms Linking Cell Mechanics and Metabolism"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Brenton Hoffman (Duke University, United States)
"Probing the Effects of Molecular Tension on Protein Function in Cellulo"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Late-Breaking Topic
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Alpha Yap (University of Queensland, Australia)
"Adherens Junctions: Mechanical Homeostasis and Epithelial Homeostasis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Cara J Gottardi (Northwestern University, United States)
"Towards a Phospho-Code for Adherens Junction Organization and Barrier Function"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Madeleine Oudin (Tufts University, United States) and Timo Kohler (University of Cambridge, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Adhesion: A Dual Carriageway of Signaling Cues
Discussion Leader: Cara J Gottardi (Northwestern University, United States)
7:30 pm - 7:55 pm
Martin Schwartz (Yale School of Medicine, United States)
"Protocadherins in Vascular Mechanotransduction, Inflammation and Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Deborah Leckband (University of Illinois at Urbana-Champaign, United States)
"Cadherin Mechanotransduction: Getting by With a Little Help From Friends"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Carl-Philipp Heisenberg (IST Austria, Austria)
"Intermediate Filaments, Desmosomes and Epithelial Morphogenesis in Zebrafish Embryos"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanical Regulation of Adhesion Signaling
Discussion Leader: Christopher Chen (Boston University , United States)
9:00 am - 9:25 am
Claudia Fischbach (Cornell University, United States)
"Extracellular Matrix and it's Role as a Biophysical Regulator of Tumor Heterogeneity"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Pere Roca-Cusachs (Institute for Bioengineering of Catalonia, Spain)
"Exploring The Role of Integrins in Nuclear Mechanosignalling"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Late-Breaking Topic
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Sanjeevi Sivasankar (University of California, Davis, United States)
"Mechanoregulation of Desmosome Architecture"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Alf Honigmann (Technical University Dresden, Germany)
"The Mechanical Role of Tight Junctions for Lumen Growth and Morphology"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Crosstalk at the Plasma Membrane
Discussion Leader: Adam Kwiatkowski (University of Pittsburgh School of Medicine, United States)
7:30 pm - 7:55 pm
Mark Peifer (University of North Carolina at Chapel Hill, United States)
"Building the Body: The Miracle of Morphogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Chiara Francavilla (Danish Technical University, Denmark)
"Novel Signalling Players Underlying Breast Cancer Cell Motility"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Justin Taraska (NHLBI, NIH, United States)
"Mapping the Structure and Dynamics of a Signaling Nexus Between Clathrin, Integrins, and Receptor Tyrosine Kinases, at the Plasma Membrane With Light and Electron Microscopy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Adhesion in Tissue Remodeling and Disease
Discussion Leader: Andrew Kowalczyk (Penn State University, United States)
9:00 am - 9:25 am
Carien Niessen (University of Cologne, Germany)
"Mechanochemical Regulation of Intercellular Junction Formation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Late-Breaking Topic
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Ann Miller (University of Michigan, United States)
"Maintenance and Remodeling of Epithelial Cell-Cell Junctions in Response to Cell Shape Changes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Celeste Nelson (Princeton University, United States)
"Adhesion Signaling in the Mesenchyme"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Volker Spindler (University Medical Center Hamburg Eppendorf (UKE), Germany)
"Novel Modulators of Desmosomal Cell Adhesion in Epidermal Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Orchestrating Adhesion and Migration
Discussion Leader: Madeleine Oudin (Tufts University, United States)
7:30 pm - 7:55 pm
Michael Sixt (Institute of Science and Technology Austria, Austria)
"Balancing Pushing and Pulling Forces in Single Cell Locomotion"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Mitchell Ho (National Cancer Institute, NIH, United States)
"Glypican-3 Modulates Wnt Signaling in Liver Cancer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Late-Breaking Topic
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Evolving Concepts of Adhesion Signaling and Cancer Progression
Discussion Leader: Daniel Conway (The Ohio State University, United States)
9:00 am - 9:25 am
Late-Breaking Topic
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Andrew Ewald (Johns Hopkins University, United States)
"Integrated Biochemical and Genetic Analysis of E-Cadherin's Role in Cancer Cell Survival During Metastasis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Late-Breaking Topic
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Sandrine Etienne-Manneville (Institut Pasteur / CNRS, France)
"Role of the Cytoskeleton in Rigidity Sensing and Mechanotransduction"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modulation of Adhesion Receptor Signaling: Clinical Applications
Discussion Leader: Panagiotis Anastasiadis (Mayo Clinic, United States)
7:30 pm - 7:55 pm
David Schlaepfer (UC San Diego, United States)
"Focal Adhesion Kinase (FAK) Signaling: Uncovering Tumor Vulnerabilities and Expanding Clinical Opportunities"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Late-Breaking Topic
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Dean Sheppard (University of California, San Francisco, United States)
"Targeting TGFß-Activating Integrins to Enhance Immune Responses to Solid Tumors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure