Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Spatial Biology of Tumor Ecosystems
Discussion Leader: Lichun Ma (National Cancer Institute, United States)
3:45 pm - 4:20 pm
Fei Chen (Broad Institute, United States)
"Single Cell Spatial Genomic Profiling of Tumor Ecosystems"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dissecting Cancer Initiation, Evolution and Drug Resistance using Single-Cell and Spatial Multi-Omics
Discussion Leader: Cathy Yan (University of British Columbia, Canada)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:00 pm
Noah Greenwald (Stanford, United States)
"The Temporal Influence of the Tumor Microenvironment in Response to Checkpoint Blockade"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Christine Yeh (Stanford University School of Medicine, United States)
"Mapping Ovarian Cancer Spatial Organization Uncovers Immune Evasion Drivers at the Genetic, Cellular, and Tissue Level"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Yikai Luo (MD Anderson Cancer Center, United States)
"Neoadjuvant PARPi and Chemotherapy in Ovarian Cancer Inform Targeting Effector Regulatory T Cells for Tumors with Homologous Recombination Deficiency"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Breanna Titchen (Harvard University, United States)
"An Ensemble of Stromal and Myeloid Populations Mediate Therapy Resistance in Metastatic Urothelial Carcinoma"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Nicholas Juul (Stanford University, United States)
"Whole Genome Methylation Sequencing Reveals the Cellular Origins of Human Lung Adenocarcinoma"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emerging Technologies and Computational Methods to Profile and Perturb Cellular States
Discussion Leader: Noah Greenwald (Stanford, United States)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:30 am
Yilin Fan (Massachusetts General Hospital, United States)
"Dissecting Cell State Plasticity in Glioblastoma through Single-Cell Lineage Tracing"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Khanh Dinh (Columbia University, United States)
"Inference for Rates of Selection and Copy Number Aberrations from DNA-Sequencing Data"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Yifan Zhao (Harvard Medical School, United States)
"High-Resolution Detection of Copy Number Alterations in Single Cells with SCANNER"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Jean-Baptiste Reynier (Columbia University, United States)
"mxTRex: Uncovering T-Cell Transcriptional Programs Associated with Antigen Specificity in Single Cell Genomics"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Jiacheng Gu (Columbia University, United States)
"CRISPRmap: Sequencing-Free Optical Pooled Screens Mapping Multi-Omic Phenotypes in Cells and Tissue"
10:30 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Shaping the Future of Single-Cell Cancer Biology
Discussion Leader: Laura Quevedo (Columbia University, United States)
1:30 pm - 2:30 pm
Panel Discussion
Shaping the Future of Single-Cell Cancer Biology
Mariella Filbin (Dana-Farber Cancer Institute/Boston Children's Hospital, United States)
Jean Fan (Johns Hopkins University, United States)
Jellert Gaublomme (Columbia University, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes