Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: AI for Genomics
7:40 pm - 8:25 pm
"Speeding-Up Scientific Discovery with AI: Agents and Foundation Models"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"The Power of a Million Cells"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Prediction of any Transcription Factor’s DNA Binding Affinity by Deep Learning"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Decoding Transcription Factor Regulation
9:00 am - 9:25 am
"AlphaGenome: Advancing Regulatory Variant Effect Prediction with a Unified DNA Sequence Model"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Footprinting with Deaminase: Mapping Transcription Factors Along the Genome on a Single-Cell and Single-Molecule Basis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Quantifying the Physical Genome, One Molecule at a Time"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Controlling CpG Islands"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"AI for Single-Cell Regulatory Genomics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
AI for Single-Cell Modeling
6:00 pm - 6:25 pm
"Causal Representation Learning for Single-Cell Genomics"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"AI for Engineering Cell State: From Text to Context"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Toward Multimodal Generative Modeling of Cellular Complexity"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Deciphering Functional Effects of Genetic Variation in Human Brain Enhancers"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Somatic mutations in disease and ageing"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"AI Scientists and Discovery Loops in Single-Cell Medicine"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Novel Sequencing Tools to Explore Translation in Individual Cells"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Modeling 3D Genome Regulation at Single-Cell Resolution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Somatic Cancer Mutations in Brain and Blood Macrophages as a Novel Genetic Contributor to Alzheimer’s Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Linking Single-Cell Omics with Large-Scale Population Genetics to Elucidate the Mechanisms of Complex Traits"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Deciphering Immune Cell Drivers of Health and Disease Through the Lens of a 40M Blood Cell Atlas"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Single-Cell and Spatial Proteomics
6:00 pm - 6:25 pm
"From Transcripts to Proteins: Principles of Protein Abundance Control Across Single Cells in Mammalian Tissues"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Fully Automated, Container-Less System for Single-Cell Processing Using Acoustic Levitation"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Joint Spatial Profiling of Transcriptome and Proteome"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Molecularly Guided Spatial Proteomics Captures Single-Cell Identity of the Healthy and Diseased Nervous System"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spatial Transcriptomics and Genomics
9:00 am - 9:45 am
"Spatially Resolved Single-Cell Genomics and Functional Genomics"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Seeing Disease in Context: AI-Driven Spatial Multi-Omics for Precision Medicine"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Cross-Species Genetic Mapping of Targets in Metabolism"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"AI/ML for Spatial Transcriptomics Across Molecular, Cellular, and Tissue Scales"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"AI-Enabled Framework for Tertiary Lymphoid Structure Detection, Phenotyping, and Patient Stratification"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:25 pm
"3D Genome Architecture Across the Life Span and in Neurodegeneration"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Single-Cell 3D Genome Structure Analysis Reveals Clonal Evolution and Heterogeneity in Acute Myeloid Leukemia"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Single-Cell Long-Read Omics Sequencing Technologies"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Gene Regulatory Landscape Dissected by Single-Cell Four-Omics Sequencing"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:35 am
"Novel Sequencing Technologies to Explore Translation in Individual Cells"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Single-Cell and Cell-Free Chromatin Codes for Tracing Developmental Lineage and Disease Cells of Origin"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Functional Phenotyping of Genomic Variants Using Joint Multiomic Single-Cell DNA–RNA Sequencing"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Single-Cell Hydroxymethylation Landscape of the Brain"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"UniGeneX Creates a Universal Gene Expression Single-Cell Atlas and Uncovers Key Transitional Pathological Cell States"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Molecule Spatial Genomics Reveals the Multiscale Organization and Plasticity of Extrachromosomal DNA in Glioblastoma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Single-Cell and Multimodal Atlas
6:00 pm - 6:45 pm
"Closing the Loop: Generative Inverse Modeling for Predictive and Interventional Single-Cell Biology"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:25 pm
"Learning Data-Driven Geometry and Dynamics for Lab-in-the-Loop AI Scientists"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Genome-Scale Perturb-Seq in Primary Human CD4+ T Cells Maps Context-Specific Regulators of T Cell Programs and Human Immune Traits"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure