Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Nucleic Acids as Molecular Tools and Markers
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:30 pm
"Spatially Resolved Single-Cell Genomics"
8:30 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"From DNA Nanotechnology to Biomedical Insight: Towards Single-Molecule Spatial Omics"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane and Cytoskeletal Organization
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Viewing Microtubule Dynamics Through an AFM Lens"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Motor Driven Membrane Organization, Molecule-by-Molecule"
10:15 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Rapid Extraction of Time-Dependent Behaviors of Endo-Lysosomal Structures and Their Cargo"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Single-Molecule Analysis of the Interplay Between Plasma Membrane Protein and Cortical Actin Dynamics"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Using Localization Microscopy to Probe the Organization and Dynamics of Membrane Proteins"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Frontiers in Molecular Imaging
7:30 pm - 7:55 pm
"Multidimensional Single-Molecule and Super-Resolution Microscopy"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Localization Microscopy Resistant to Photobleaching"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"MINFLUX for Dynamic Structural Cell Biology"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"High-Speed Atomic Force Microscopy (HS-AFM) Single-Molecule Structural Biology: Rare and Transient Conformational States in Membrane Proteins"
9:25 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Glycolipid Protocells Satisfy Conditions for Darwinian Evolution"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Uncovering the Biochemical and Biophysical Mechanisms Governing Selective Enzymatic Activity in Nutrient-Starved Escherichia Coli via Live-Cell Single-Molecule Tracking"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Structural Basis of Negative Supercoiling Induced CRISPR Cas9 Off-Target Activity"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Denovo Design of Pore-Forming Proteins for Sensing and Sequencing Applications"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Understanding Molecular Ratchets Through the Eyes of Einstein and G.N. Lewis"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Spectroscopy and Intramolecular Investigations
7:30 pm - 8:00 pm
"Built-in On-Off Switch for Transcription"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Monitoring the Phosphorylation Cycles of Single Molecules in Solution by Their Charge"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Probing the Influence of Excitonic State Localization on the Distribution of Ultrafast Energy Timescales in Phycobiliproteins via Single-Molecule Pump-Probe"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Probing the Interaction Dynamics of Intrinsically Disordered Proteins with Single-Molecule Spectroscopy"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Designing Brighter Dyes for Advanced Fluorescence Microscopy and Beyond"
9:30 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Multiplexed Combinatorial DNA-PAINT for MINFLUX Nanoscopy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:10 am
"Single Particle Tracking from Integrative Detectors to SPAD Arrays"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Towards Universal and Quantitative Single Molecule Biophysics with Mass Photometry"
11:40 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Real-Time 3D Single Particle Tracking in an Electric Field"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Single Molecule Dynamics and Mechanisms Involving G-Rich DNA Structures"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Massively Parallel Analysis of Single-Molecule Dynamics on Next Generation Sequencing Chips"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Single-Molecule Imaging Exposes the Mechanism of RNP Formation of LINE-1 Retrotransposons"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Probing the Mechanics of Single Human Mitotic Chromosomes with Optical Tweezers and Fluorescence Microscopy"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Molecular Recognition and Forces
9:00 am - 9:25 am
"Conformational Dynamics and Mechanotransduction in Single Integrin Molecules"
9:25 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Untangling Chromatin Looping: A Biophysical Characterization of CCCTC-Binding Factor (CTCF)"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Herpes Simplex Virus Type 1 (HSV-1) Origin Binding Protein UL9 Tethers dsDNA"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:50 am
"Accurate Drift-Invariant Single-Molecule Force Calibration Using the Hadamard Variance"
10:50 am - 10:55 am
Discussion
10:55 am - 11:20 am
"Interface Resistance of Biomolecular Condensates"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"New Metastable Nano-Liquid Signal Integration Platform on the Cell Membrane, iTRVZ"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Molecule Dynamics Show the ATP-Driven Distribution of a Carbon-Fixing Organelle in Bacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Nanoscale Cell Biology
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Single Molecule studies of Phosphoinositide Signaling in Living Cells"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 9:05 pm
"Super-Resolution Imaging of Transcription in Living Cells"
9:05 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure