Dynamics Across Vigilance States

The 2024 Sleep Regulation and Function: Dynamics Across Vigilance States will be the fifth Sleep GRC. The field of sleep research has enjoyed an increase in interest across a wide range of academic research disciplines ranging from molecular biology to data science. Sleep is not studied in insolation, i.e., as a state in itself, but as part of the alternation between sleep and wakefulness. Sleep is not a homogenous state; apart from the alternation between NREM and REM sleep, there are profound dynamic changes within these two states. It is felt that a quantitative description and understanding of these dynamics at various levels of organization will provide better insights in sleep’s function and regulation.The program will cover: The dynamic life of synapses; REM sleep dynamics, models and dreams; Quantifying EEG oscillations, dynamics and their functional and physiological correlates; Molecular and functional correlates of sleep and sleep loss in rodents and flies; Activation, reactivation and the role of sleep and sleep circuits in motor learning; Extracting sleep and circadian parameters from big and longitudinal data; Modulating remembering and forgetting by sleep and neuromodulation; Microglial dynamics across the sleep-wake cycle and the Locus coeruleus, sleep and attention.