Sunday
|
4:00 pm - 8:00 pm |
Arrival and Check-in
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Stem Cells, Cancer and Cell Fate Diversity
Discussion Leader: Amy Wagers (Harvard University, USA)
|
7:40 pm - 7:50 pm |
Opening Remarks
|
7:50 pm - 8:35 pm |
Irving Weissman (Stanford University School of Medicine, USA)
"CD47: Don't Eat Me!"
|
8:35 pm - 8:55 pm |
Discussion
|
8:55 pm - 9:20 pm |
Robert Blelloch (University of California, San Francisco, USA)
"Exosomes as Modulators of Anti-Tumor Immune Response"
|
9:20 pm - 9:30 pm |
Discussion
|
Monday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Developmental Pathways
Discussion Leader: Meritxell Huch (University of Cambridge, United Kingdom)
|
9:00 am - 9:25 am |
Hanna Mikkola (University of California, Los Angeles, USA)
"Decoding Human Hematopoietic Stem Cell Self-Renewal"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 9:50 am |
Youcef Ouadah (Stanford University School of Medicine, USA)
"A Subpopulation of Pulmonary Neuroendocrine Cells Are Reserve Stem Cells Regulated by the Tumor Suppressors Rb, p53 and Notch"
|
9:50 am - 9:55 am |
Discussion
|
9:55 am - 10:20 am |
Kenneth Zaret (Perelman School of Medicine, University of Pennsylvania, USA)
"Overcoming Chromatin Impediments in Endoderm Development and Reprogramming"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:25 am |
Shahragim Tajbakhsh (Institut Pasteur, France)
"Skeletal Muscle Stem Cells in Developmental and Regenerative Myogenesis"
|
11:25 am - 11:35 am |
Discussion
|
11:35 am - 11:50 am |
Nina Oberbeck (Genentech Inc., USA)
"The Ripk4-Irf6 Signaling Axis Ensures Epidermal Differentiation and Barrier Function"
|
11:50 am - 11:55 am |
Discussion
|
11:55 am - 12:10 pm |
Erez Cohen (Duke University, USA)
"Developmental Rewiring of an Injury Response from Regeneration to Hypertrophy in the Drosophila Hindgut Pylorus"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Organogenesis and Tumorigenesis
Discussion Leader: Leonard Zon (Howard Hughes Medical Institute / Boston Children's Hospital, USA)
|
7:30 pm - 7:55 pm |
Cedric Blanpain (Université Libre de Bruxelles, Belgium)
"Role of Adult Stem Cells in Tissue Homeostasis, Cancer Initiation and Relapse"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:25 pm |
Ya-chieh Hsu (Harvard University, USA)
"Nerve-Stem Cell Interactions During Tissue Regeneration"
|
8:25 pm - 8:35 pm |
Discussion
|
8:35 pm - 8:50 pm |
Oh-Joon Kwon (University of Washington, USA)
"Sox2 Regulates Bipotent Potential of Sca-1+ Luminal Cells of Murine Prostatic Proximal Ducts"
|
8:50 pm - 8:55 pm |
Discussion
|
8:55 pm - 9:20 pm |
Meritxell Huch (University of Cambridge, United Kingdom)
"Stem Cells and Tissue Regeneration in the Liver"
|
9:20 pm - 9:30 pm |
Discussion
|
Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Self-Renewal and Differentiation Mechanisms
Discussion Leader: Jason Buenrostro (Harvard University, USA)
|
9:00 am - 9:25 am |
Sean Morrison (University of Texas Southwestern Medical Center, USA)
"Metabolic Heterogeneity Among Melanoma Cells Confers Differences in Metastatic Potential"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 9:50 am |
Markus Schober (NYU School of Medicine, USA)
"A Bi-Stable Transcriptional Network Motif Governs Self-Renewal and Differentiation in SCCs"
|
9:50 am - 9:55 am |
Discussion
|
9:55 am - 10:20 am |
Magdalena Goetz (Ludwig Maximilian University of Munich, Germany)
"Novel Mechanisms of Merunogenesis and Direct Neuronal Reprogramming"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:25 am |
Leonard Zon (Howard Hughes Medical Institute / Boston Children's Hospital, USA)
"Stem Cells, Niches and the Emergence of Hematopoietic Clonality"
|
11:25 am - 11:35 am |
Discussion
|
11:35 am - 11:50 am |
Albert Almada (Harvard University, USA)
"Uncovering Early Events in Stem Cell Activation Driving Skeletal Muscle Regeneration: Immediate Action by a Stress-Responsive Transcriptional Regulator"
|
11:50 am - 11:55 am |
Discussion
|
11:55 am - 12:20 pm |
Pekka Katajisto (Karolinska Institutet, Sweden / University of Helsinki, Finland)
"Aging of the Niche Attenuates Intestinal Regeneration"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Genomics and Epigenomics
Discussion Leader: Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
|
7:30 pm - 7:55 pm |
Maarten Van Lohuizen (Netherlands Cancer Institute, The Netherlands)
"Polycomb Group Genes in Stem Cell Fate and Tumorigenesis"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:30 pm |
Hans-Reimer Rodewald (German Cancer Research Center, Germany)
"Unravelling Stem Cell Fates, Lineage Relationships and Clone Sizes"
|
8:30 pm - 8:40 pm |
Discussion
|
8:40 pm - 8:55 pm |
Maria Abad (Vall d'Hebron Institute of Oncology (VHIO), Spain)
"Mining the Microproteome for New Players in Cancer Cell Plasticity"
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Jason Buenrostro (Harvard University, USA)
"Single-Cell Epigenomics: Gene Regulation at Unprecedented Resolution"
|
9:20 pm - 9:30 pm |
Discussion
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Metabolism and Metastasis
Discussion Leader: Peter de Keizer (University Medical Center Utrecht, The Netherlands)
|
9:00 am - 9:25 am |
Leanne Jones (University of California, Los Angeles, USA)
"Metabolic Regulation of Stem Cell Function"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 9:50 am |
Stefanie Tiede (University of Basel, Switzerland)
"Tumor Heterogeneity During the Progression of Metastatic Breast Cancer"
|
9:50 am - 9:55 am |
Discussion
|
9:55 am - 10:20 am |
Felipe de Sousa e Melo (Genentech, USA)
"Colon Cancer Stem Cell Dynamics in Primary and Metastatic Tumors"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:25 am |
Bill Lowry (University of California, Los Angeles, USA)
"Metabolic Manipulation of Hair Follicle Stem Cells"
|
11:25 am - 11:35 am |
Discussion
|
11:35 am - 11:50 am |
Shiri Gur-Cohen (Rockefeller University, USA)
"A Stem Cell-Driven Lymphoangiogenic Switch Coordinates Tissue Regeneration"
|
11:50 am - 11:55 am |
Discussion
|
11:55 am - 12:20 pm |
Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
"Retinoic Acid Signaling in Muscle Stem Cell Aging"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Cell Fate and Aging Effects
Discussion Leader: Leanne Jones (University of California, Los Angeles, USA)
|
7:30 pm - 7:55 pm |
Salvador Aznar Benitah (Institute for Research in Biomedicine (IRB Barcelona), Spain)
"Epigenetic Memory in Metastatic-Initiating Cells: Why What We Eat Matters"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:25 pm |
Peter de Keizer (University Medical Center Utrecht, The Netherlands)
"Senescence in Tissue Rejuvenation and Cancer"
|
8:25 pm - 8:35 pm |
Discussion
|
8:35 pm - 8:50 pm |
Cora Olpe (MRC Cambridge Stem Cell Institute, United Kingdom)
"Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium"
|
8:50 pm - 8:55 pm |
Discussion
|
8:55 pm - 9:20 pm |
Saul Villeda (University of California, San Francisco, USA)
"Mechanisms of Brain Aging and Rejuvenation"
|
9:20 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Pluripotency and Lineage Plasticity
Discussion Leader: Catriona Jamieson (University of California, San Diego, USA)
|
9:00 am - 9:25 am |
Kathrin Plath (University of California, Los Angeles, USA)
"A New Mechanism of Gene Silencing by Xist RNA"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 9:50 am |
Paige Arnold (Memorial Sloan Kettering Cancer Center, USA)
"Glutamine Independence Is a Selectable Feature of Pluripotent Stem Cells"
|
9:50 am - 9:55 am |
Discussion
|
9:55 am - 10:10 am |
Gabriella Ficz (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"Transition to Human Naïve Pluripotency Models Pan-Cancer DNA Hypermethylation"
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:45 am |
Coffee Break
|
10:45 am - 11:00 am |
Ramanuj Dasgupta (Genome Institute of Singapore, A*STAR, Singapore)
"Mapping Trajectories of Drug-Induced Tumor Evolution 'One Cell at a Time'"
|
11:00 am - 11:05 am |
Discussion
|
11:05 am - 11:30 am |
Sören Müller (Genentech Inc., USA)
"Tracing Fibroblasts During Pancreatic Cancer Progression at Single-Cell Resolution"
|
11:30 am - 11:40 am |
Discussion
|
11:40 am - 12:05 pm |
Laura Banaszynski (University of Texas Southwestern Medical Center, USA)
"Building an Active Enhancer to Drive Cell Fate Decisions"
|
12:05 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Diwakar Pattabiraman (Norris Cotton Cancer Center, Dartmouth College, USA)
"PKA Signaling Shapes Tumor Evolution by Regulating Lineage Plasticity and Differentiation in Breast Cancer"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Disease Modeling and Therapeutics
Discussion Leader: Jill Goldstein (Harvard University, USA)
|
7:30 pm - 7:50 pm |
Leo Wang (City of Hope National Medical Center, USA)
"Improving Therapeutic Efficacy of Chimeric Antigen Receptor T Cells in Pediatric Neuromalignancies"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Catriona Jamieson (University of California, San Diego, USA)
"How Cancer Stem Cells Evade Chemotherapy"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 9:15 pm |
Elaine Fuchs (The Rockefeller University, USA)
"Cellular Cross-Talk in Epithelial Wound Repair and Cancer"
|
9:15 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|