Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Clinical and Translational Insights into Streptococcal and Enterococcal Pathobiology
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Relating Animal Model Data to the Pathogenesis of Human Streptococcus Pneumoniae Infections"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"How to Make a Second-Rate Pathogen Into a First-Rate Clinical Problem: The Enterococcal Conundrum"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The Ever-Expanding Streptococcus Pyogenes Human Challenge Universe"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms Underlying Streptococcal and Enterococcal Pathophysiology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Stacked Bistable Regulation of Widespread Streptococcal ICEs Conferring MDR"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Under Pressure: Evolution of Hyper-Virulent Variants of Group B Streptococcus in Diabetic Wound Infection"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"From Mechanistic Studies of Streptococcal CNS Infection to the Discovery of a BBB-Permeabilizing Protein"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"New Insights Into Gram-Positive Bacterial Membrane Lipids"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Exploring the Impact of Fatty Acid Metabolism on Streptococcus Physiology and Virulence"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Biofilm Dispersion in Enterococcus faecalis is Triggered by Nutrient Step-Change and Requires the Peptidoglycan Hydrolase SalA"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Genetic Interaction Mapping with Transposons Uncovers New Biology in Streptococcus Pneumoniae "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Biofilms and Microbial Community Interactions
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Insights Into Streptococcus mutans and Candida albicans Synergism Beyond the Biofilm Matrix"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Strep Shapes Polymicrobial Biofilm Life in the Human Mouth"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Identification of Commensal Bacterial Species That Prevent Streptoccocus Pneumoniae Colonization of the Nasal Epithelium"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Community Interactions Shape GBS Persistence in the Vaginal Microbiome"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Host–Pathogen Interactions Shaping Streptococcal and Enterococcal Diseases
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Transcriptional Reprogramming Enables Pneumococcal Expansion in the Influenza-Primed Lung"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Pneumolysin-Dependent Damage During Streptococcus Pneumoniae Infection"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Group B Streptococcus Hyaluronidase Promotes Lung Invasion and Early Onset Disease"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"From Plaque to Platelets: Determining the Role of Oral Streptococci in Endocarditis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Oxidized LDL Elicits Trained Immunity to Streptococcus pneumoniae in the Lung Via LOX-1-Dependent and Independent Mechanisms"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Breaking Barriers: Understanding and Targeting Enterococcus faecalis Translocation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Behind the Blood-Brain Barrier: Mapping the Brain’s Immune Response to Group B Streptococcus Meningitis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathogenic Strategies and Virulence Mechanisms
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Beyond Secretion: Expanding Roles of the Type VII Secretion System in Virulence"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Host–Response Signatures in Invasive Group A Streptococcal Infection"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"A Seven-Protein Complex Neutralized the Pore-Forming Activity of TelE in Streptococcus Gallolyticus "
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"The Role of a Conserved Orf in Metal Homeostasis in Streptococcus and Other Gram-Positive Pathogens"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Signaling Pathways Controlling Streptococcal and Enterococcal Behavior and Adaptation
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Suppression of Innate Immune Signaling by Streptococcus Pyogenes Is Governed by Bacterial Communication"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Adaptive Evolution of CovR Signaling Shapes Group B Streptococcus Virulence"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Exploiting Vancomycin Resistance to Drive Antibiotic Synergy in Enterococcus Faecalis "
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"CroRS Signaling Failure Leads to β-Lactam Sensitivity Through C-Di-AMP Dysregulation in Enterococcus Faecalis "
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Neuron-endothelial Cell Crosstalk Protects the Blood-Brain Barrier from Group B Streptococcal Invasion and Disruption"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"The Diabetic Urinary Environment Enhances Group B Streptococcus Fitness and Impairs Host Response"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"MutRS Quorum-Sensing Systems Drive Interspecies Communication Between the Dental Pathogens Streptococcus Mutans and Streptococcus Sobrinus "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
CRISPR-Cas Systems and Phage Dynamics in Streptococcal and Enterococcal Biology
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:25 pm
"Mystery at The Membrane: How Metal Flux Impacts Pneumococcal Biology"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Functional Genomics and Phage Therapy for Antibiotic-Resistant Enterococcal Infections"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"A Cryptic Prophage Dramatically Enhances CRISPR-Cas Immunization in Streptococcus Pyogenes"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Efagins: Engineerable Agents That Target the Enterococcal Cell Wall"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genomics and Functional Roles of Streptococci and Enterococci in Microbiome Systems
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"From Precise Microbial Genomics to Precision Medicine"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Living in a Lactobacillus World: Group B Streptococcus in the Vaginal Microenvironment"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"The Hunt for Correlates of Protection: Changes Over Time in Strep A-Specific Serum IgG Among School-Aged Children"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"On the Role of Enterococcus as a Commensal of the Gut Microbiome in Cell Therapies Against Cancer"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Metagenomics of Neonatal Gut Colonization by Group B Streptococcus Reveals Competitive Advantages for the Hypervirulent Clonal Complex 17"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Genetic Diversity of Streptococcus Pyogenes Pbp2x From England and Wales, 2001–2015"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Revisiting Vancomycin Resistance in Enterococci"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Antimicrobial Resistance and Therapeutic Strategies
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Preclinical Assessment of Non-M Protein Group A Streptococcal Vaccines"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Cross-Resistance to Immunity and Antibiotics Emerges from a Shared Microbial Target"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Engineering the First Recombinant Glycoconjugate Vaccine Platform Against Human and Veterinary Streptococci"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Teaching an Old Pathogen New Tricks: How the Pneumococcus Evades Antibiotics"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure