1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Epigenome Actuation: Engineering Proteins that Sense Chromatin Signals and Regulate Genes
Alexander Vlahos (Stanford University, United States)
3:45 pm - 4:00 pm
Tetsuhiro Harimoto (Harvard University, United States) "A Programmable Encapsulation of Bacteria for Therapeutic Delivery to Tumors"
4:00 pm - 4:05 pm
4:05 pm - 4:25 pm
Marta Napiorkowska (University of Cambridge, United Kingdom) "Efficient Exploration of Protein Sequence Space with in Vivo Mutagenesis in Yeast"
4:25 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Theory and Tools for Expanding Synthetic Biology
Ke Wang (Monash University, Australia) and Nicolas Huguenin-Dezot (ETH Zürich, Switzerland)
7:30 pm - 7:45 pm
Miguel Alcantar (MIT, United States) "Predicting Combinatorial Chromatin-based Transcriptional Regulation Using Supervised Machine Learning"
7:45 pm - 7:50 pm
7:50 pm - 8:05 pm
Jacob Shenker (Harvard Medical School, United States) "Exploring Protein and Circuit Design Spaces Using Massively Parallel Microscopy-Based Screening"
8:05 pm - 8:10 pm
8:10 pm - 8:25 pm
Nathan Wang (MIT, United States) "System Biology-Guided Design and Molecular Optimization of Transcription Factor Cassetts for Robust, Highly Efficient Reprograming"
8:25 pm - 8:30 pm
8:30 pm - 8:45 pm
John Allan (University of Oxford, United Kingdom) "Cybernetic Control of Microbial Communities and Bioprocesses"
8:45 pm - 8:50 pm
8:50 pm - 9:05 pm
Cristina Tous (Boston University, United States) "Optogenetic Control of Mammalian Cell Fate using Recombinases"
9:05 pm - 9:10 pm
9:10 pm - 9:25 pm
Robert Pecoraro (University of Washington, United States) "Computational Design of Sequence-Specific DNA-Binding Proteins"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Applications in Human and Environmental Health
Discussion Leaders: System.String and
Eric South (Boston University, United States)
9:00 am - 9:15 am
Lynn Sidor (University of Rochester, United States) "
Opticoli: Self-Assembled Bacterial Microlenses for Optical Applications"
9:15 am - 9:20 am
9:20 am - 9:35 am
Kiara Reyes Gamas (Rice University, United States) "Uncovering the Networks and Dynamics of Horizontal Gene Transfer in Environmental Microbial Communities using Genetic Memory"
9:35 am - 9:40 am
9:40 am - 9:55 am
Benedikt Mortzfeld (University of Massachusetts Chan Medical School, United States) "Microcin MccI47 Selectively Inhibits Enteric Bacteria and Reduces Carbapenem-Resistant Klebsiella Pneumoniae Colonization in Vivo when Administered via an Engineered Live Biotherapeutic"
9:55 am - 10:00 am
10:00 am - 10:15 am
Marianna Mignanelli (Scuola Normale Superiore di Pisa, Italy) "Chimeric HIV-1 Pr55 (Gag) Virus-Like Particles: An Innovative Nanodevice for Cellular-Specific miRNA Profiling in the Nervous System"
10:15 am - 10:20 am
10:20 am - 10:35 am
Carolina Monck (Imperial College London, United Kingdom) "Temperature Responsive Synthetic Cells for Advanced Drug Delivery"
10:35 am - 10:40 am
10:40 am - 10:55 am
Daniel Richter (ETH Zurich, Switzerland) "Protein Labeling using Endogenous ß-Amino Acid Dienophiles Derived from Natural Product Biosynthesis"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Careers in Synthetic Biology
Tetsuhiro Harimoto (Harvard University, United States) and Ginevra Camboni (University of York, United Kingdom)
1:30 pm - 2:10 pm
Synthetic Biology Careers
Charles Hong (Defense Threat Reduction Agency, United States)
Elizabeth Onderko (Capra Biosciences, United States)
Narendra Maheshri (Ginkgo Bioworks, United States)
2:10 pm - 2:30 pm
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)