| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: A Sulfur-Centered World:
From Primordial Chemistry
to Human Biology |
| Discussion Leaders: Tobias Dick (German Cancer Research Center, Germany) and Vadim Gladyshev (Harvard Medical School, USA) |
| 7:40 pm - 8:20 pm | Ruma Banerjee (University of Michigan, USA)
"Signaling Through Sulfide: Chemical Biology of Sulfide
Homeostasis" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Michel Toledano (French Alternative Energies and Atomic Energy Commission (CEA), France)
"The Control of Eukaryotic Protein Secretion by a Novel Pathway Regulating Glutathione Traffic in and out of the ER" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Emerging
Chemical, Omics and Computational Tools for Redox Biologists |
| Discussion Leaders: Vsevolod Belousov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia) and Leslie Poole (Wake Forest School of Medicine, USA) |
| 9:00 am - 9:20 am | Dean Jones (Emory University, USA)
"Exposure Memory and the Redox Theory of Aging" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Harry Ischiropoulos (University of Pennsylvania, USA)
"Potential Functional Roles for Redox Regulated Cysteine Residues" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Melissa Kemp (Georgia Institute of Technology, USA)
"Computational Strategies for Interrogating Thiol Regulated Systems" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Eranthie Weerapana (Boston College, USA)
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Milos Filipovic (IBGC - Institut de Biochimie et Genetique Cellulaires / CNRS, France)
"Thioredoxin Controls Intracellular Levels of Protein Persulfidation" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Troy Langford (Massachusetts Institute of Technology, USA)
"Using Kinetic Models and Engineered Proteins to Further Quantitative Understanding of Thiol-Based Redox Regulation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Essential
Function of H2S and Other S-Containing Biomolecules in Human Health and Biology |
| Discussion Leaders: Ming Xian (Washington State University, USA) and Rodney Levine (National Institutes of Health, USA) |
| 7:30 pm - 7:50 pm | Alban Longchamp (Harvard University, USA)
"Regulation of Endogenous H2S and Mechanisms of Action in Angiogenesis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Ed Schmidt (Montana State University, USA)
"The Robustness of Mammalian Redox Homeostasis: NADPH-Dependent and -Independent Disulfide Reductase Systems" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Michael Pluth (University of Oregon, USA)
"Synthetic H2S Donors with Defined Release Mechanisms and Tunable Release Rates" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Bruno Manta (Brigham and Women's Hospital / Harvard Medical School, USA)
"Reversible Methionine Oxidation by Mical/MsrB as a New Axis in Redox Regulation and Signaling" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Weijun Qian (Pacific Northwest National Laboratory, USA)
"Stoichiometric Quantification of S-Glutathionylation and Total Thiol Oxidation and Potential Crosstalk with Protein Phosphorylation" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jen-Tsan Chi (Duke University, USA)
"Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas" |
| 9:25 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Exploiting
Redox Effects in Modern Therapeutics |
| Discussion Leaders: Kate Carroll (The Scripps Research Institute, USA) and Arne Holmgren (Karolinska Institutet, Sweden) |
| 9:00 am - 9:20 am | David Boothman (University of Texas Southwestern Medical School, USA)
"Exploiting NQO1 Bioactivatable Drugs for Tumor-Selective DNA Repair Inhibition" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Brion Murray (Pfizer Oncology Research Unit, USA)
"Protein S-Glutathionylation: An Emerging Post-translational Modification that Impacts Cell Biology and the Disease State" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Daret St. Clair (University of Kentucky, USA)
"A Redox Distinction Approach to Cancer Therapy" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Martin Bergo (Karolinska Institute, Sweden)
"On the Role of Antioxidants in Tumor Initiation and Progression" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Yvonne Janssen-Heininger (University of Vermont, USA)
"Targeting S-Glutathionylation Chemistry to Combat Tissue Fibrosis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Jade Mims (Wake Forest School of Medicine, USA)
"Integration of Redox-Regulated Signaling and Metabolism in Head and Neck Cancer" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Redox
Regulation of Cellular Communication |
| Discussion Leaders: Thomas Michel (Brigham and Women's Hospital / Harvard Medical School, USA) and Sue Goo Rhee (Yonsei University College of Medicine, South Korea) |
| 7:30 pm - 7:50 pm | Agnieszka Chacinska (International Institute of Molecular and Cell Biology in Warsaw, Poland)
"Cellular Consequences of Mitochondrial Stress" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Michael Ristow (Energy Metabolism Laboratory, ETH Zurich, Switzerland)
"Mitochondria, Metabolism and Aging" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Patricia Zambryski (University of California, Berkeley, USA)
"Plant Cell-to-Cell Communication via Plasmodesmata: Regulation by Organelle Redox State" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Stefano Bestetti (Fondazione Centro San Raffaele, Italy)
"Regulation of H2O2 Transport in Tumor Growth and Progression" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Prakash Palde (The Scripps Research Institute, USA)
"Thioredoxin Selectively Recognizes Oxidized Target Proteins via an Entropy-Driven Common Mechanism" |
| 9:25 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Case
Studies in Redox Control of Cellular Processes |
| Discussion Leaders: Elena Hidalgo (Pompeu Fabra University, Spain) and Tobias Dansen (University Medical Center Utrecht, The Netherlands) |
| 9:00 am - 9:20 am | Jose Antonio Barcena (University of Cordoba, Spain)
"Redox Control of Protein Thiols by Redoxins Under Nitric Oxide Signaling" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Myra Conway (University of the West of England, United Kingdom)
"Dysregulated Redox Metabolons and Their Implications in Alzheimer's Disease" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Ana Denicola (University of the Republic, Uruguay)
"Interplay Between Nitration and Overoxidation in Peroxiredoxins. Impact on H2O2 Detoxification and Signaling" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Malcolm Jackson (University of Liverpool, United Kingdom)
"Redox Signaling of Adaptive Responses to Contractile Activity in Skeletal Muscle" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Carola Neumann (Magee-Womens Research Institute, USA)
"PRDX1 in Redox Regulation of Cancer Signaling" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Sarah Stöcker (German Cancer Research Center (DKFZ), Germany)
"Thiol Peroxidase Based Redox Relays" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Signaling
Mediated by Reactive Oxygen, Nitrogen and Sulfur Species |
| Discussion Leaders: Christine Winterbourn (University of Otago, Christchurch, New Zealand) and Trent Tipple (University of Alabama at Birmingham, USA) |
| 7:30 pm - 7:50 pm | Elizabeth Veal (Newcastle University, United Kingdom)
"Role of Peroxiredoxins in Redox Signaling, Stress Responses and Ageing" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Takaaki Akaike (Tohoku University Graduate School of Medicine, Japan)
"Cysteinyl-tRNA Synthetase Controls Protein Polysulfidation and Mitochondrial Functions" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Massimo Santoro (VIB Vesalius Research Center, KU Leuven, Belgium)
"Redox Signaling and Metabolism in Angiogenesis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Gary Loake (University of Edinburgh, United Kingdom)
"A Central Role for S-Nitrosylation in Plant Immunity" |
| 9:20 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | Redox Research
at the Interface of Environment, Aging and Cancer |
| Discussion Leaders: Ursula Jakob (University of Michigan, USA) and W. Todd Lowther (Wake Forest School of Medicine, USA) |
| 9:00 am - 9:20 am | Anna Rubartelli (IRCCS AOU San Martino IST, Italy)
"Targeting Cellular Stress Responses to Prevent Tumor Onset and Progression: Redox-Related
Mechanisms and Preclinical Studies" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Mary Helen Barcellos-Hoff (University of California, San Francisco, USA)
"Redox Regulation of TGFβ and Its Implications in Cancer Biology" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | John Mieyal (Case Western Reserve University, USA)
"The Yin and Yang of Glutaredoxin Homeostasis in Brain Cells: Implications for Parkinson's Disease" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | David Gius (Feinberg School of Medicine, Northwestern University, USA)
"SIRT3 Is a Mitochondrial Fidelity Protein Directing
the Metabolic Stress Response" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Beatriz Alvarez (University of the Republic, Uruguay)
"Reaction of Thiols with Conjugated Nitrolinoleic Acid" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Jesalyn Bolduc (Wake Forest School of Medicine, USA)
"Unlocking the Mystery of Variable Hyperoxidation Sensitivity in Peroxiredoxins: Two Novel, Key Motifs" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Thiols
and Antioxidant Defense in Bacteria, Plants and Beyond |
| Discussion Leaders: Luise Krauth-Siegel (Heidelberg University, Germany) and Andreas Meyer (University of Bonn, Germany) |
| 7:30 pm - 7:50 pm | Joris Messens (VIB, Vrije Universiteit Brussel, Belgium)
"Promiscuity in Thiol Redox Control" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Frederic Barras (CNRS, France)
"How to Keep Fe-S Clusters Delivery Efficient Under Iron Limitation (and Other Difficulties)?" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Gloria Muday (Wake Forest University, USA)
"The Role of Flavonols as Antioxidants Protecting Pollen from High Temperature-Induced ROS" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Limei Zhang (University of Nebraska-Lincoln, USA)
"The WhiB Proteins in Stress Response in Mycobacterium tuberculosis" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Edward Chouchani (Dana-Farber Cancer Institute, USA)
"Mitochondrial ROS Regulate Thermogenic Energy Expenditure and Sulfenylation of UCP1" |
| 9:25 pm - 9:30 pm | Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
