This conference has been withdrawn from the 2020 conference schedule
As you are aware, coronavirus is having a global impact and the World Health Organization and the Centers for Disease Control have instituted recommendations that include social distancing and cancelling conferences and large gatherings. Since safety of our attendees is always GRC's highest priority, the GRC Board of Trustees has decided to withdraw this conference and it will be rescheduled for 2022. This decision was made out of an abundance of caution and to alleviate the concerns of our conference communities that are scheduled to meet in this timeframe.
A fundamental goal of biology is to understand the rules behind life's use of chemical space. A prime example, and the focal point of this meeting, is the defining thiol (–SH) functional group in the amino acid, cysteine. The unique biophysical and electronic properties of sulfur atom in the side chain endows cysteine with the ability to undergo a wide array of chemical modifications. Specialized protein microenvironments created by protein structure motifs can favor the polarization of sulfur and tune the inherent chemical reactivity of cysteine. The oxidation or covalent modification of cysteine can have a profound effect on protein conformation, location, and function. Today, redox signaling mediated by reversible oxidation of protein cysteines resides is recognized as a major regulatory mechanism in many cellular processes. Cysteine oxidation can also impact the clinical performance of drugs, especially irreversible thiol-modifying inhibitors.
This meeting brings together outstanding scientists from around the world to present and discuss new and emerging concepts in thiol-based redox regulation and signaling. Presentations will focus on foundational topics in thiol-based redox signaling. Which redox-active components are present at which concentrations? Where in the cell are which redox conditions prevalent? Which cysteine residues in which proteins are modified under what conditions? How are biological processes influenced by thiol-based modifications? What are the mechanisms and interrelation of reactive species build up, adaptation and signaling? Detailed knowledge of thiol-based mechanisms of redox signaling under physiological and pathological conditions will engender a deeper understanding of the redox component in human health and disease, ultimately, leading toward a new era of redox medicine.