A fundamental goal of biology is to understand the rules behind life's use of chemical space. A prime example, and the focal point of this meeting, is the defining thiol (–SH) functional group in the amino acid, cysteine. The unique biophysical and electronic properties of sulfur atom in the side chain endows cysteine with the ability to undergo a wide array of chemical modifications. Specialized protein microenvironments created by protein structure motifs can favor the polarization of sulfur and tune the inherent chemical reactivity of cysteine. The oxidation or covalent modification of cysteine can have a profound effect on protein conformation, location, and function. Notably, cysteine was fixed in the genetic code at a relatively late stage of evolution, concurrent with evolution of multicellular organisms, O2 sensing and H2O2 signaling systems. Today, redox signaling mediated by reversible oxidation of protein cysteines resides is recognized as a major regulatory mechanism in many cellular processes. Cysteine oxidation can also impact the clinical performance of drugs, especially irreversible thiol-modifying inhibitors.
This meeting brings together outstanding scientists from around the world to present and discuss new and emerging concepts in thiol-based redox regulation and signaling. Presentations will focus on foundational topics in thiol-based redox signaling. Which redox-active components are present at which concentrations? Where in the cell are which redox conditions prevalent? Which cysteine residues in which proteins are modified under what conditions? How are biological processes influenced by thiol-based modifications? What are the mechanisms and interrelation of reactive species build up, adaptation and signaling? Detailed knowledge of thiol-based mechanisms of redox signaling under physiological and pathological conditions will engender a deeper understanding of the redox component in human health and disease, ultimately, leading toward a new era of redox medicine.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by October 15, 2019. Please check back for updates.
- Methionine Oxidation and Selenoproteins
- Glutathione in Regulation and Detoxification
- Keynote Session: Nitrosylation: The Prototypic Redox Modification and Therapeutic Target
- Quantitative Measures of Redox Signaling
- Redox Metabolism in Health and Disease
- Mechanisms of H2O2 Signaling: Direct Oxidation
- Mechanisms of H2O2 Signaling: One- and Two-Component Relays
- Reactive Sulfur Species in Metabolism and Signaling
- Advances in Redox Medicine