Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Pioneers in Redox Regulation and Signaling
Discussion Leader: Ursula Jakob (University of Michigan, USA)
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7:40 pm - 8:20 pm |
Helmut Sies (Heinrich Heine University Dusseldorf, Germany)
"H2O2 and Thiol-Based Redox Signaling"
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8:20 pm - 8:35 pm |
Discussion
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8:35 pm - 9:15 pm |
Rafael Radi (Universidad de la Republica, Uruguay)
"Peroxynitrite, Peroxiredoxins and Carbon Dioxide: Thiol Oxidation and Overoxidation"
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9:15 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Enabling Technologies for Redox Biology
Discussion Leaders: Vsevolod Belousov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia) and Elena Hidalgo (Pompeu Fabra University, Spain)
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9:00 am - 9:10 am |
Short Talk Selected from Poster Abstracts
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9:10 am - 9:15 am |
Discussion
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9:15 am - 9:25 am |
Cristina Furdui (Wake Forest University School of Medicine, USA)
"[18F]Fluoro-DCP: A First Generation PET Radiotracer for Monitoring Protein Sulfenylation in vivo"
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9:25 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Derek Pratt (University of Ottawa, Canada)
"The Inhibition of Lipid Peroxidation and Associated Cell Death by Persulfides"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:20 am |
Yimon Aye (École Polytechnique Fédérale de Lausanne, Switzerland)
"Lighting the Way: Precision Electrophile-Sensing and -Signaling Interrogations Open Up New Opportunities"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Che Pillay (University of Kwazulu-Natal, South Africa)
"Quantifying Signaling from Dynamic Redox Profile Data"
|
11:20 am - 11:30 am |
Discussion
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11:30 am - 11:50 am |
Gregory Payne (University of Maryland, USA)
"Targeting Redox Inputs by Mediated Electrochemistry: From Characterizing Oxidative Stress to Electrogenetics"
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11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Jing Yang (National Center for Protein Sciences, Beijing, China)
"Profiling the Proteome-Wide Selectivity of Oxoform-Specific Probes"
|
12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Ursula Jakob (University of Michigan, USA) and Bindu Paul (Johns Hopkins School of Medicine, USA)
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4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
Grand Challenges and New Paradigms in Thiol-Based Redox Signaling
Discussion Leader: Toren Finkel (Aging Institute, University of Pittsburgh Medical Center, USA)
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6:00 pm - 6:20 pm |
Ruma Banerjee (University of Michigan, USA)
"A Metabolic Paradigm for H2S Signaling"
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6:20 pm - 6:30 pm |
Discussion
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6:30 pm - 6:50 pm |
Pietro Ghezzi (Università di Urbino, Italy)
"Thiol Regulation of Innate Immunity"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Vadim Gladyshev (Brigham and Women's Hospital / Harvard Medical School, USA)
"Systems Approaches to Thiol- and Selenol-Based Redox Control"
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7:20 pm - 7:30 pm |
Discussion
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7:30 pm - 7:50 pm |
Benoit D'Autréaux (Institute for Integrative Biology of the Cell, CEA, CNRS, Paris-Saclay university, France)
"Fe-S Cluster Assembly: The Intersection of Inorganic and Organic Sulfur Chemistry"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 9:00 pm |
Dinner
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Molecular Mechanisms of Thiol-Based Redox Regulation
Discussion Leaders: Elizabeth Veal (Newcastle University, United Kingdom) and Philip Eaton (Queen Mary University of London, United Kingdom)
|
9:00 am - 9:10 am |
Short Talk Selected from Poster Abstracts
|
9:10 am - 9:15 am |
Discussion
|
9:15 am - 9:25 am |
W. Todd Lowther (Wake Forest School of Medicine, USA)
"Molecular Basis for the Specificity of Thiostreption Targeting Human Peroxiredoxin 3"
|
9:25 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Brian Smith (Medical College of Wisconsin, USA)
"Protein Cysteine Sulfenylation By Oxidized Lipid Signaling Promotes Platelet Activation"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
James Galligan (University of Arizona, USA)
"Glutathione as a Critical Mediator of Post-Translational Modifications"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Tobias Dick (German Cancer Research Center (DKFZ), Germany)
"Mechanisms of Sulfane Sulfur Mediated Cytoprotection"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Ana Denicola (University of the Republic, Uruguay)
"Dynamics of hPrx Oligomerization: Is it Related to Catalysis?"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Hadley Sikes (Massachusetts Institute of Technology, USA)
"Detecting and Targeting Compartment-Specific Vulnerabilities in Redox Metabolism"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Targeting Thiol Redox State and Oxidative Stress in Disease
Discussion Leader: Leslie Poole (Wake Forest School of Medicine, USA)
|
6:00 pm - 6:20 pm |
Michael Pluth (University of Oregon, USA)
"New Approaches for H2S and Sulfane Sulfur Delivery"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Carmen Wong (The University of Hong Kong, Hong Kong SAR China)
"Redox Homeostasis in Hepatocellular Carcinoma and its Therapeutic Implications"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Bruce Freeman (University of Pittsburgh, USA)
"Clinical Development of Cysteine Proteome-Targeted Nitroalkenes"
|
7:20 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:50 pm |
Yvonne Janssen-Heininger (Larner College of Medicine, University of Vermont, USA)
"Glutaredoxin-Mediated Control of GSH: A Thiol Connection with System XC- and Relevance to Lung Cancer"
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7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Thiol-Based Redox Signaling Pathways
Discussion Leaders: Albert Van Der Vliet (University of Vermont, USA) and Carola Neumann (Magee-Womens Research Institute, USA)
|
9:00 am - 9:20 am |
Fernando Antunes (Faculdade de Ciências da Universidade de Lisboa, Portugal)
"Hydrogen Peroxide Signaling in Aging"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Michel Toledano (French Alternative Energies and Atomic Energy Commission (CEA), France)
"Deciphering the Redox Control of Secretion: A Unique Function of Glutathione in the Endoplasmic Reticulum"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Carolyn Sevier (Cornell University, USA)
"Redox Signaling at the Endoplasmic Reticulum"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:10 am |
Short Talk Selected from Poster Abstracts
|
11:10 am - 11:15 am |
Discussion
|
11:15 am - 11:25 am |
Benoit Boivin (SUNY Polytechnic Institute, USA)
"Regulation of Protein Tyrosine Phosphatase 1B Reduction in Insulin Resistance"
|
11:25 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Pat Eyers (University of Liverpool, United Kingdom)
"Cysteine-Based Signaling Networks: New Kinase Connections"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Amit Reddi (Georgia Institute of Technology, USA)
"Sod1 Integrates Oxygen Availability to Redox Regulate NADPH Production and the Thiol Redoxome"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Thiol-Based Redox Metabolism
Discussion Leader: Roberto Sitia (Vita-Salute San Raffaele University, Italy)
|
6:00 pm - 6:20 pm |
Bruce Morgan (Universität des Saarlandes, Biochemie, Germany)
"Novel Genetically Encoded Sensors for Real-Time Monitoring of the Subcellular NADP+/NADPH Ratio"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Carolina Greco (University of California Irvine, USA)
"Rewiring of Hepatic Redox Metabolism in a Model of Heart Failure"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Canhua Huang (Sichuan University, China)
"Redox Regulation of Cancer Drug Resistance"
|
7:20 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:50 pm |
Oleh Khalimonchuk (University of Nebraska-Lincoln, USA)
"Redox-Mediated Regulation of Mitochondrial Sculpting"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
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Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Sulfinic Acid, Selenoproteins and Reversible Methionine Oxidation
Discussion Leader: Guo-Li Song (Shenzhen Bay Laboratory, China)
|
9:00 am - 9:20 am |
Bruno Manta (Institut Pasteur Montevideo and Universidad de la Republica, Uruguay)
"Metagenomics for the Discovery on New Redox Enzymes"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Rodney Levine (National Institutes of Health, USA)
"Mechanism of Oxidative Activation of Autonomy in Ca/Calmodulin-Dependent Kinase"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Sina Ghaemmaghami (University of Rochester, USA)
"Proteome-Wide Surveys of Methionine Oxidation and Reduction"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Robert Hondal (University of Vermont, USA)
"Cheating on Selenium"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Daniel Bak (Boston College, USA)
"Targeting the Selenoproteome through Chemoproteomics"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Emily Flashman (University of Oxford, United Kingdom)
"New Insights into Cysteine Dioxygenase Function"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Reactive Sulfur Species in Redox Signaling
Discussion Leader: Peter Nagy (National Institute of Oncology, Hungary)
|
6:00 pm - 6:10 pm |
Short Talk Selected from Poster Abstracts
|
6:10 pm - 6:15 pm |
Discussion
|
6:15 pm - 6:25 pm |
Beatriz Alvarez (Universidad de la Republica, Uruguay)
"Acidity and Nucleophilicity of Persulfides"
|
6:25 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Ming Xian (Brown University, USA, USA)
"Chemical Tools for Understanding Reactive Sulfur Species"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Bindu Paul (Johns Hopkins School of Medicine, USA)
"Neuroprotective Role of Hydrogen Sulfide in Alzheimer's disease"
|
7:20 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:50 pm |
David Giedroc (Indiana University, USA)
"Thiols and Thiol Persulfides in Bacterial Pathogens: Sensing and Beyond"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|