The 2020 Gordon Research Conference on Three-Dimensional Electron Microscopy will celebrate its 35th year of existence, by continuing the tradition of highlighting the best of cutting-edge research in 3DEM.
Technological breakthroughs of the past few years have resulted in monumental success and expansion in the field. In some ways, solving structures of macromolecular complexes to atomic resolution has become almost routine. Yet there are many exciting challenges that still confront us, including needs for hardware and platform innovation, reproducible and efficient sample preparation, higher throughput, algorithm development, data validation, and reaching towards dynamic and ever smaller complexes. The accumulation of huge data sets requires data mining and dissemination tools in order to best exploit these rich resources of information.
Developments in cellular tomography provide us with new ways to capture biological structures in situ. FIB-milling, correlative light microscopy, phase plate technology and development of data acquisition and processing schemes have brought exciting new results to the field and rapid progress.
Other innovations include sample preparation for tissues and thicker specimens, chemical analysis, automated data segmentation and analysis. Technologies such as cryo-STEM tomography, cryo-Xray tomography, cryoFIB blockface SEM imaging can bridge the gap between high resolution and large volumes. 3D imaging in larger cellular contexts is required to answer questions in fields such as inter-organelle communication, inter-cellular communication, biomineralization and host-pathogen contacts.
The 2020 3DEM GRC will feature scientific talks presenting state-of-the-art aspects of cryo-EM research. The meeting will kick off with a special treat. In the Keynote Session, the three 2017 Chemistry Nobel Prize laureates will discuss their visions for what lies ahead in the 3DEM field. We will continue with the popular tradition of having two evening sessions dedicated for selected poster presentations. There will be ample opportunities for senior and junior scientists to interact during social events and poster sessions. Due to limited attendance (< 200 participants) and the over-subscribed nature of previous meetings, early registration is encouraged.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by October 15, 2019. Please check back for updates.
- Keynote Session: The Future Impact of 3DEM on Structural Biology Research: Nobel Perspectives
- Sample Preparation and Workflows
- Hardware and Instrument Developments
- Cellular and Molecular Tomography
- Selected Poster Presentations: Breakthrough Methods and Workflows
- Hybrid and Correlative Methods
- Innovations in Algorithms and Software
- CryoEM in Drug Discovery
- Selected Poster Presentations: Solving Challenging Structures