Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: The Future of 3DEM in Structural Biology: Beyond Cryo-EM
Discussion Leader: Eva Nogales (University of California, Berkeley, United States)
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7:40 pm - 7:45 pm |
Opening Remarks
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7:45 pm - 8:00 pm |
Introduction by Discussion Leader
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8:00 pm - 8:20 pm |
Melanie Ohi (University of Michigan, United States)
"From Blobs to Atoms and Back to Blobs — Embracing the Full Power of 3D Electron Microscopy"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Saori Maki-Yonekura (RIKEN SPring-8 Center, Japan)
"Hydrogen Properties and Charges in Crystal and Single Particle Cryo-EM Structures"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Jonas Adler (DeepMind, United Kingdom)
"Highly Accurate Protein Structure Prediction with AlphaFold"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Advances in Specimen Preparation and Workflows
Discussion Leader: Hongwei Wang (Tsinghua University, China)
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9:00 am - 9:15 am |
Introduction by Discussion Leader
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9:15 am - 9:35 am |
Doryen Bubeck (Imperial College London, United Kingdom)
"How CD59 Bocks a Giant Beta Barrel Pore: a Tale of David and Goliath"
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9:35 am - 9:50 am |
Discussion
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9:50 am - 10:10 am |
Shengjie Feng (UCSF, United States)
"Tagging Endogenous Proteins in Mice for Solving Structures"
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10:10 am - 10:25 am |
Discussion
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10:25 am - 10:50 am |
Coffee Break
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10:50 am - 11:10 am |
Thamiya Vasanthakumar (Fred Hutchinson Cancer Center, United States)
"Overcoming Instability and Heterogeneity for Cryo-EM of the V1 Complex"
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11:10 am - 11:20 am |
Discussion
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11:20 am - 11:40 am |
Arjen Jakobi (Kavli Institute of Nanoscience Delft, The Netherlands)
"Nanofluidic Cavities for Reproducible Cryo-EM Sample Preparation with Minimal Sample Volumes"
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11:40 am - 11:55 am |
Discussion
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11:55 am - 12:15 pm |
Seychelle Vos (MIT, United States)
"Artificial Intelligence-Guided Cryo-EM Data Collection"
|
12:15 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:30 pm |
Free Time
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3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Lisa Eshun-Wilson (Scripps Research Institute, United States) and Maria Flores (UCLA, United States)
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4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
3DEM in Translational Research
Discussion Leader: Pamela Williams (Astex Pharmaceuticals, United Kingdom)
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6:00 pm - 6:15 pm |
Introduction by Discussion Leader
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6:15 pm - 6:35 pm |
Claudio Ciferri (Genentech, United States)
"CryoEM as an Integral Part of Drug Development"
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6:35 pm - 6:50 pm |
Discussion
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6:50 pm - 7:10 pm |
Christopher Barnes (Stanford University, United States)
"Targeting Conserved Neutralizing Epitopes on Viral Glycoproteins"
|
7:10 pm - 7:25 pm |
Discussion
|
7:25 pm - 7:45 pm |
Shee-Mei Lok (Duke-NUS Medical School, Singapore)
"Structures of DENV Morphological Variants"
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7:45 pm - 8:00 pm |
Discussion
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8:00 pm - 9:00 pm |
Dinner
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
New Developments in Algorithms and Software
Discussion Leader: Joachim Frank (Columbia University, United States)
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9:00 am - 9:15 am |
Introduction by Discussion Leader
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9:15 am - 9:35 am |
Jose Carazo (Spanish National Center for Biotechnology, CSIC, Spain)
"Macromolecular Continuous Flexibility with Zernike3D: Conformational Landscapes and Improved Resolution in a Simple and User Friendly Environment"
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9:35 am - 9:50 am |
Discussion
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9:50 am - 10:10 am |
Sjors Scheres (MRC Laboratory of Molecular Biology, United Kingdom)
"New Developments in RELION-4 and Beyond"
|
10:10 am - 10:25 am |
Discussion
|
10:25 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Matthew Iadanza (CCPEM - Science and Technology Facilities Council, United Kingdom)
"CCP-EM Pipeliner/Doppio: Software Tools for Efficient, Accurate, and Reproducible Management and Automation of CryoEM Processing Workflows"
|
11:10 am - 11:20 am |
Discussion
|
11:20 am - 11:40 am |
Tristan Bepler (Simons Machine Learning Center, United States)
"Learning to Simultaneously Locate and Classify Particles in Cryo-Electron Micrographs Without Supervision"
|
11:40 am - 11:55 am |
Discussion
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11:55 am - 12:15 pm |
Ricardo Sánchez Loayza (EMBL Heidelberg, Germany)
"SUSAN: High Performance Framework for Fast and Flexible Subtomogram Averaging"
|
12:15 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Selected Poster Presentations: Recent Breakthroughs in 3DEM
Discussion Leader: Mario Borgnia (National Institutes of Health, United States)
|
6:00 pm - 6:10 pm |
Short Talk Selected from Poster Abstracts
|
6:10 pm - 6:15 pm |
Discussion
|
6:15 pm - 6:25 pm |
Short Talk Selected from Poster Abstracts
|
6:25 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:40 pm |
Short Talk Selected from Poster Abstracts
|
6:40 pm - 6:45 pm |
Discussion
|
6:45 pm - 6:55 pm |
Short Talk Selected from Poster Abstracts
|
6:55 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:10 pm |
Short Talk Selected from Poster Abstracts
|
7:10 pm - 7:15 pm |
Discussion
|
7:15 pm - 7:25 pm |
Short Talk Selected from Poster Abstracts
|
7:25 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:40 pm |
Short Talk Selected from Poster Abstracts
|
7:40 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Short Talk Selected from Poster Abstracts
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Frontiers in Cellular Tomography
Discussion Leader: Julia Mahamid (European Molecular Biology Laboratory, Germany)
|
9:00 am - 9:15 am |
Introduction by Discussion Leader
|
9:15 am - 9:35 am |
Rainer Kaufmann (University of Hamburg, Germany)
"Photo-Physics and Cryo Super-Resolution Fluorescence Imaging"
|
9:35 am - 9:50 am |
Discussion
|
9:50 am - 10:10 am |
Stefan Raunser (Max Planck Institute of Molecular Physiology, Germany)
"Cryo-ET Reveals Sarcomere Structures at Molecular Resolution"
|
10:10 am - 10:25 am |
Discussion
|
10:25 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Alex de Marco (Monash University, Australia)
"Deciphering the Molecular Composition of Cells: New Approaches to Visual Proteomics"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:40 am |
David Agard (University of California, San Francisco, United States)
"Improved BIM Correction for CryoTomo and Fully Automated, Local Motion Corrected, Marker Free, Tomographic Alignment and Reconstruction"
|
11:40 am - 11:55 am |
Discussion
|
11:55 am - 12:15 pm |
Late-Breaking Topic
|
12:15 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Structures In Situ: Pushing Resolution Limits
Discussion Leader: John Briggs (Max Planck Institute of Biochemistry, Germany)
|
6:00 pm - 6:15 pm |
Introduction by Discussion Leader
|
6:15 pm - 6:35 pm |
Liang Xue (European Molecular Biology Laboratory(EMBL), Germany)
"Visualizing Translation Dynamics at Atomic Detail Inside Bacterial Cells"
|
6:35 pm - 6:50 pm |
Discussion
|
6:50 pm - 7:10 pm |
Friedrich Foerster (Utrecht University, The Netherlands)
"Molecular Snapshots of Translation and Protein Translocation at the ER Membrane"
|
7:10 pm - 7:25 pm |
Discussion
|
7:25 pm - 7:45 pm |
Late-Breaking Topic
|
7:45 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Innovations of Instruments and Hardware
Discussion Leader: Henning Stahlberg (EPFL & Uni Lausanne, Switzerland)
|
9:00 am - 9:15 am |
Introduction by Discussion Leader
|
9:15 am - 9:35 am |
Keiichi Namba (Osaka University, Japan)
"High-Throughput High-Resolution CryoEM Single Particle Image Analysis by CRYO ARM and EG-Grid"
|
9:35 am - 9:50 am |
Discussion
|
9:50 am - 10:10 am |
Peiyi Wang (Southern University of Science and Technology, China)
"Chromatic Aberration Corrected Cryo-EM"
|
10:10 am - 10:25 am |
Discussion
|
10:25 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Holger Mueller (University of California, Berkeley, United States)
"Laser Phase Plate: Advancing Beyond Proof-of-Concept"
|
11:10 am - 11:20 am |
Discussion
|
11:20 am - 11:40 am |
Scott Stagg (Florida State University, United States)
"Throughput and Resolution on the Apollo Direct Electron Detector"
|
11:40 am - 11:55 am |
Discussion
|
11:55 am - 12:15 pm |
Late-Breaking Topic
|
12:15 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Selected Poster Presentations: New Developments in 3DEM
Discussion Leader: Radostin Danev (The University of Tokyo, Japan)
|
6:00 pm - 6:10 pm |
Short Talk Selected from Poster Abstracts
|
6:10 pm - 6:15 pm |
Discussion
|
6:15 pm - 6:25 pm |
Short Talk Selected from Poster Abstracts
|
6:25 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:40 pm |
Short Talk Selected from Poster Abstracts
|
6:40 pm - 6:45 pm |
Discussion
|
6:45 pm - 6:55 pm |
Short Talk Selected from Poster Abstracts
|
6:55 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:10 pm |
Short Talk Selected from Poster Abstracts
|
7:10 pm - 7:15 pm |
Discussion
|
7:15 pm - 7:25 pm |
Short Talk Selected from Poster Abstracts
|
7:25 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:40 pm |
Short Talk Selected from Poster Abstracts
|
7:40 pm - 7:45 pm |
Discussion
|
7:45 pm - 8:00 pm |
General Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|