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Three Dimensional Electron Microscopy (GRS)

Gordon Research Seminar

Visualizing Biological Complexity Across Scales in 3DEM

October 30 - 31, 2021

Chairs Ann C. Varano and Colin M. Palmer

Contact Chairs

Waterville Valley

56 Packard's Road

Waterville Valley, NH, US

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Three Dimensional Electron Microscopy is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The cryo-EM revolution is continuing to provide insight into ever larger and more complex biomolecular systems. This meeting will focus on new techniques and experiments that increase our understanding of the structure and function of biomolecules at multiple scales, putting detailed molecular structures into their cellular context. There will be plenty of opportunity for early-career scientists to present their work and make connections with other junior researchers to shape the future of the field.

Related Meeting

This GRS will be held in conjunction with the "Three Dimensional Electron Microscopy" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Structure among the Chaos: Using Cellular Tomography to Study Mitochondrial Behavior Discussion Leader: Gregor Weiss (ETH Zurich, Switzerland)
3:45 pm - 3:55 pm	Introduction by Discussion Leader
3:55 pm - 4:20 pm	Danielle Grotjahn (Scripps Research, USA) "Structure Among the Chaos: Using Cellular Tomography to Study Mitochondrial Behavior"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Putting Structures in Context Discussion Leader: Bronwyn Lucas (University of Massachusetts Medical School, USA)
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 7:50 pm	Paula Navarro (Massachusetts General Hospital / Harvard Medical School, USA) "In Situ Architecture and Dynamics of Bacterial Cell Division Dictate Polar Shape"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	Qiu Yu Huang (University of Massachusetts Medical School, USA) "Quantitative Structural Analysis of Influenza Virus by Cryo-Electron Tomography and Convolutional Neural Networks"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	Steffen Klein (Heidelberg University, Germany) "In Cellulo Cryo-CLEM Reveals the Antiviral Effect of IFITM3 by Arresting the Hemifusion State During Influenza A Virus Membrane Fusion"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:35 pm	Jie Yang (University of Wisconsin-Madison, USA) "Exploring In Situ Viral Infection with Multi-Modal Cryogenic Correlative FLM-FIB/SEM for Vitrified Mammalian Cells"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	Michael Wozny (MRC Laboratory of Molecular Biology, United Kingdom) "In Situ Cryo-Electron Tomography of the ER-Mitochondria Encounter Structure in Yeast"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	Sven Klumpe (Max-Planck-Institute for Biochemistry, Germany) "In Situ Structural Analysis of the Nuclear Pore Complex in Drosophila melanogaster Egg Chambers"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	Christian Zimmerli (Max Planck Institute for Biophysics, Germany) "Membrane Tension Regulates Nuclear Pore Diameter"
9:20 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Understanding Structural Dynamics Discussion Leader: James Chen (New York University, USA)
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:20 am	Anna Talyzina (Northwestern University, USA) "Structure of the Human Mediator-Bound Transcription Preinitiation Complex"
9:20 am - 9:25 am	Discussion
9:25 am - 9:35 am	Dominik Herbst (University of California, Berkeley, USA) "Structure of the Human SAGA Coactivator Complex"
9:35 am - 9:40 am	Discussion
9:40 am - 9:50 am	Maximilian Sauer (University of Washington, USA) "Broadly Neutralizing β-Coronavirus Antibodies that Protect Against SARS-CoV-2 Variants of Concern by Blocking the Fusion Machinery"
9:50 am - 9:55 am	Discussion
9:55 am - 10:05 am	Sophie Gobeil (Duke Human Vaccine Institute, USA) "Emerging SARS-CoV-2 Variants: How Natural Mutations Impact the Structure, Conformation and Antigenicity of the Spike Protein"
10:05 am - 10:10 am	Discussion
10:10 am - 10:20 am	Chen Sun (Purdue University, USA) "Ab Initio Helical Indexing in Real Space Without the Need for Fourier Layer Lines"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	Anthony Schuller (Massachusetts Institute of Technology, USA) "The Cellular Environment Shapes the Nuclear Pore Complex Architecture"
10:35 am - 10:40 am	Discussion
10:40 am - 10:50 am	Peter Kirchweger (Weizmann Institute of Science, Israel) "CSTET: A Window into the Cell"
10:50 am - 10:55 am	Discussion
10:55 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: How to Make the Most Out of Scientific Networking Discussion Leader: Philipp Erdmann (Human Technopole, Italy)
1:30 pm - 2:15 pm	Panel Discussion How to Make the Most out of Scientific Networking Danielle Grotjahn (Scripps Research, USA) Daniela Nicastro (University of Texas Southwestern Medical Center, USA) Sharon Wolf (Weizmann Institute of Science, Israel)
2:15 pm - 2:30 pm	Closing Remarks
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes