1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: The Changing Face of TB Drug Discovery
Luiz Pedro Carvalho (The Francis Crick Institute, United Kingdom) and Magdalena Bielecka (University of Southampton, United Kingdom)
3:15 pm - 3:45 pm
Stewart Cole (Ecole Polytechnique Federale de Lausanne - EPFL, Switzerland) "The Changing Face of TB Drug Discovery"
3:45 pm - 4:00 pm
4:00 pm - 5:30 pm
5:30 pm - 7:30 pm
Evaluating Mechanisms of Resistance and Overcoming Them
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and modulate factors that confer drug resistance.
Anthony Baughn (University of Minnesota, USA) and Vinayak Singh (Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa)
5:30 pm - 5:50 pm
Pooja Gopal (National University of Singapore, Singapore) "From Mechanisms of Resistance to a Mechanism of Action for Pyrazinoic Acid and Its Prodrug Pyrazinamide"
5:50 pm - 6:00 pm
6:00 pm - 6:20 pm
Abrar Abidi (Institute for Systems Biology, USA) "The Program of Gene Transcription for the Hypoxia and Reaeration Response in MTB"
6:20 pm - 6:30 pm
6:30 pm - 6:50 pm
Sarah Scarry (University of North Carolina at Chapel Hill, USA) "Strained Amine Heterocycles as Non-Hydrolyzable β-Lactam Surrogates: Mechanistic and Structure-Activity Probes for
6:50 pm - 7:00 pm
7:00 pm - 7:20 pm
Dirk Lamprecht (Africa Health Research Institute, South Africa) "Synergistic Targeting of
Mycobacterium tuberculosis Energy Metabolism"
7:20 pm - 7:30 pm
8:00 pm - 9:00 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Identification and Evaluation of Novel Drug Targets
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and exploit novel drug targets.
Mary Jackson (Colorado State University, USA) and Erik Hasenoehrl (Albert Einstein College of Medicine, USA)
9:00 am - 9:20 am
Samantha Wellington (Harvard University, USA) "Identification of a Specific, Allosteric Small-Molecule Inhibitor of
Mycobacterium tuberculosis Tryptophan Synthase"
9:20 am - 9:30 am
9:30 am - 9:50 am
Shuyi Ma (Center for Infectious Disease Research, USA) "Data-Driven Inference of Drug Synergy"
9:50 am - 10:00 am
10:00 am - 10:20 am
Eachan Johnson (Broad Institute of MIT and Harvard, USA) "A New Platform for Anti-Tubercular Drug Discovery"
10:20 am - 10:30 am
10:30 am - 10:50 am
Yesha Patel (Indian Institute of Technology Bombay, India) "Oxidative Stress: A Potential Target for Combination Therapy Against
10:50 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Translation from the Benchtop to the Bedside: Identifying and Combating
Mtb in the Community Translational research towards identifying novel diagnostic tools, vaccines, and getting new therapies into humans.
Laura Via (National Institute of Allergy and Infectious Diseases, NIH, USA) and Jinghang Xie (Stanford University School of Medicine, USA)
1:30 pm - 1:50 pm
Mireille Kamariza (Stanford University, USA) "Detection of Live Mycobacteria with a Solvatochromic Trehalose Probe for Point-of-Care Tuberculosis Diagnosis"
1:50 pm - 2:00 pm
2:00 pm - 2:20 pm
Chandrani Thakur (Indian Institute of Science Bangalore, India) "Unbiased Identification of Blood-Based Biomarkers for Prognosis of Treatment in Tuberculosis Patients"
2:20 pm - 2:30 pm
2:30 pm - 3:00 pm
Fill in GRS Evaluation Forms