Sunday 
 
 
4:00 pm - 8:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
 
 
						
7:40 pm - 9:30 pm 
	
Vascular Signaling Networks in Development and Disease 
 
 
 
						
7:40 pm - 7:45 pm 
	
Introduction by Discussion Leader
 
 
						
7:45 pm - 8:05 pm 
	
"Arterial-Venous Programming in Development and Disease" 
 
 
 
						
8:05 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:30 pm 
	
"VEGF-B: The Yin and Yang in Angiogenesis" 
 
 
 
						
8:30 pm - 8:35 pm 
	
Discussion
 
 
						
8:35 pm - 8:55 pm 
	
"Neural Progenitor Cell-Mediated Spatiotemporal Control of Spinal Cord Vascularization" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Energy Substrate Partitioning and Regulation in Endothelial Cells" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signalling to Limit Specification of the Lymphatic Lineage" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Vascular Specification and Guidance and Organ-Specific Vasculature 
New cellular and molecular mechanisms responsible for vascular guidance and specification will be presented. Specific attributes of blood vessels organization in various organs will be discussed. 
 
 
 
						
9:00 am - 9:20 am 
	
"Neurovascular Communication During CNS Development" 
 
 
 
						
9:20 am - 9:25 am 
	
Discussion
 
 
						
9:25 am - 9:45 am 
	
"Guidance of Vascular Barrier Formation" 
 
 
 
						
9:45 am - 9:50 am 
	
Discussion
 
 
						
9:50 am - 10:10 am 
	
"Organotypic Differentiation, Regeneration and Angiocrine Functions of the Liver Vasculature" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:45 am 
	
Coffee Break
 
 
						
10:45 am - 11:05 am 
	
"Specification of Hematopoietic Stem Cells from Hemogenic Endothelium" 
 
 
 
						
11:05 am - 11:10 am 
	
Discussion
 
 
						
11:10 am - 11:20 am 
	
"MicroRNA-223 Establishes a Specialized Glycome that Limits Hematopoietic Stem Cell Production from Endothelium" 
 
 
 
						
11:20 am - 11:25 am 
	
Discussion
 
 
						
11:25 am - 11:35 am 
	
"Mechanosensory Function of Kindlin3 in Microglia Is Crucial for Retinal Vascular Patterning" 
 
 
 
						
11:35 am - 11:40 am 
	
Discussion
 
 
						
11:40 am - 11:50 am 
	
"Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung" 
 
 
 
						
11:50 am - 11:55 am 
	
Discussion
 
 
						
11:55 am - 12:05 pm 
	
"Neural JNK3 Regulates Blood Flow Recovery After Hindlimb Ischemia in Mice via an Egr1/Creb1 Axis" 
 
 
 
						
12:05 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Inflammatory Networks and Vascular Niche 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Inflammation in the Vascular Wall" 
 
 
 
						
7:50 pm - 7:55 pm 
	
Discussion
 
 
						
7:55 pm - 8:15 pm 
	
"Dendritic Cells in Vascular and Lymphatic Biology" 
 
 
 
						
8:15 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:40 pm 
	
"Early Vascular Development in Zebrafish and Mouse" 
 
 
 
						
8:40 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"The Functional Contribution of Endothelial-to-Mesenchymal Transition to Organ Fibrosis" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Endothelial Pannexin1-Purinergic Signaling Axis Is a Key Regulator of the Cerebral Ischemic Response" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Dynamic Stroma Reorganization Drives Blood Vessel Dysmorphia During Glioma Progression: A Role for SLIT-ROBO Vascular Guidance Pathway" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Mechanobiology of Vascular and Lymphatic Systems 
 
 
 
						
9:00 am - 9:20 am 
	
"Systems Approach of Flow Regulation of KLF4-ITPR3 Axis in Endothelium" 
 
 
 
						
9:20 am - 9:25 am 
	
Discussion
 
 
						
9:25 am - 9:35 am 
	
"Shear Stress Activation of the Klf2 Pathway" 
 
 
 
						
9:35 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 9:50 am 
	
"Human Genetics in Vascular Mechanotransduction and Metabolism" 
 
 
 
						
9:50 am - 9:55 am 
	
Discussion
 
 
						
9:55 am - 10:15 am 
	
"Directional Migration of Immune Cells: Chemokine Gradients, Traction Forces and Upstream Control" 
 
 
 
						
10:15 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:10 am 
	
"Development and Maintenance of Organ-Specific Lymphatic Vasculature" 
 
 
 
						
11:10 am - 11:15 am 
	
Discussion
 
 
						
11:15 am - 11:35 am 
	
"Differentiation of Endothelial Cells and Establishment of Organ-Specific Vessels" 
 
 
 
						
11:35 am - 11:40 am 
	
Discussion
 
 
						
11:40 am - 11:55 am 
	
"Focal Adhesion EphA2 Signaling Promotes Contractility to Drive Fibrillar Adhesion Formation and Fibronectin Deposition" 
 
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Opposing Functions of Beta1-Integrin in Control of Vascular Integrity and Inflammation-Induced Leakage" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Novel Regulatory Circuits in Vascular Development and Pathologies: Microvasculature and Long Non-Coding RNAs 
 
 
 
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						
7:35 pm - 7:55 pm 
	
"Transcriptional and Epigenetic Alterations in Endothelium Post-S1P Receptor Signaling" 
 
 
 
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"Long Non-Coding RNAs in Vasculature" 
 
 
 
						
8:20 pm - 8:25 pm 
	
Discussion
 
 
						
8:25 pm - 8:45 pm 
	
"Impact of Clonal Hematopoiesis in Vascular Disease" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:10 pm 
	
"Prion-Mediated Activation of Endothelial Cell Signaling Networks in Brain Development and Disease" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"The Combinatorial Roles of TCF7L2 and GATA6 in Vascular Smooth Muscle Differentiation and Prevention of Intimal Hyperplasia" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Recent Advances in Vascular Engineering, Targeting and Imaging 
 
 
 
						
9:00 am - 9:20 am 
	
"Imaging Neurovascular Interactions in Disease" 
 
 
 
						
9:20 am - 9:25 am 
	
Discussion
 
 
						
9:25 am - 9:45 am 
	
"Targeted Cas9 Nanomedicines and DNA Barcodes" 
 
 
 
						
9:45 am - 9:50 am 
	
Discussion
 
 
						
9:50 am - 10:00 am 
	
"Microengineered Human Blood Vessel for Next Generation Drug Discovery" 
 
 
 
						
10:00 am - 10:05 am 
	
Discussion
 
 
						
10:05 am - 10:35 am 
	
Coffee Break
 
 
						
10:35 am - 10:55 am 
	
"Tissue Specific Vascular Endothelium Contribute to Organotropic Metastasis" 
 
 
 
						
10:55 am - 11:00 am 
	
Discussion
 
 
						
11:00 am - 11:10 am 
	
"Blood Vessel Regression in Adult Mammalian Brains" 
 
 
 
						
11:10 am - 11:15 am 
	
Discussion
 
 
						
11:15 am - 11:25 am 
	
"Endothelial Cell Expressed Piezo1 Regulates Pressure-Induced Lung Vascular Permeability" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:40 am 
	
"Foxc1 Regulation of mTOR Signaling During Physiological and Pathological Postnatal Retina Angiogenesis" 
 
 
 
						
11:40 am - 11:45 am 
	
Discussion
 
 
						
11:45 am - 11:55 am 
	
"Age-Dependent Modulation of the Human Skin Microvasculature by Microenvironment and Serum" 
 
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:00 pm - 7:30 pm 
	
Business Meeting 
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 
 
 
						
7:30 pm - 9:30 pm 
	
Vascular Cell Fate and Disease 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Perivascular Cells Are a Novel Source of Tissue Resident M2 Macrophages Important in Regulation of Vascular Integrity and Tissue Metabolism" 
 
 
 
						
7:50 pm - 7:55 pm 
	
Discussion
 
 
						
7:55 pm - 8:15 pm 
	
"Regulation of Vascular Permeability" 
 
 
 
						
8:15 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:40 pm 
	
"Molecular Heterogeneity and Functional Specialization of Vascular Cells" 
 
 
 
						
8:40 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"NCK-Dependent Pericyte Migration Promotes Pathological Neovascularization in Ischemic Retinopathy" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Genetic Inactivation of the Pluripotency Factor OCT4 Within Endothelial Cells Leads to Enhanced Atherosclerosis in Apoe-/- Mice" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Integrin-Specific Signaling Drives ER Stress to Promote JNK Signaling and Atherogenic Endothelial Activation" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Metabolic Control of Vasculature and Blood Vessels in Metabolic Diseases 
 
 
 
						
9:00 am - 9:20 am 
	
"Endocrine Function of Endothelium in Metabolism and Inflammation" 
 
 
 
						
9:20 am - 9:25 am 
	
Discussion
 
 
						
9:25 am - 9:35 am 
	
"Control of Perivascular Adipose Tissue Development and Thermogenesis by Early B Cell Factor 2" 
 
 
 
						
9:35 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:00 am 
	
"Molecular and Therapeutic Aspects of Blood-Brain Barrier Regulation" 
 
 
 
						
10:00 am - 10:05 am 
	
Discussion
 
 
						
10:05 am - 10:15 am 
	
"Dual Roles of PKM2 in Endothelial Cell Proliferation and Vascular Permeability" 
 
 
 
						
10:15 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:10 am 
	
"Myeloid Cells in Vasculature" 
 
 
 
						
11:10 am - 11:15 am 
	
Discussion
 
 
						
11:15 am - 11:30 am 
	
"Reducing VEGF-B Signalling Ameliorates Hepatic Steatosis and Prevents Development of Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma" 
 
 
 
						
11:30 am - 11:35 am 
	
Discussion
 
 
						
11:35 am - 11:45 am 
	
"Exercise Promotes White Adipose Tissue Angiogenesis and Protects from Diet-Induced Metabolic Defects" 
 
 
 
						
11:45 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:00 pm 
	
"PGC-1a/ARHGAP6 Axis Mediates Diabetic Vascular Dysfunction Through Diminution of Endothelial Glycolytic Flux" 
 
 
 
						
12:00 pm - 12:05 pm 
	
Discussion
 
 
						
12:05 pm - 12:15 pm 
	
"Organ-Specific Heterogeneity in Endothelial Cell Hypoxia Response" 
 
 
 
						
12:15 pm - 12:20 pm 
	
Discussion
 
 
						
12:20 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Keynote Session: Mechanisms of Vascular Inflammation and Aging 
 
 
 
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						
7:35 pm - 8:00 pm 
	
"Mitochondrial Control of Inflammation: Positive and Negative Control of the NLRP3 Inflammasome" 
 
 
 
						
8:00 pm - 8:15 pm 
	
Discussion
 
 
						
8:15 pm - 8:20 pm 
	
Introduction by Discussion Leader
 
 
						
8:20 pm - 8:45 pm 
	
"PAD4: The Nuclear Button of Inflammation and Aging" 
 
 
 
						
8:45 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:20 pm 
	
General Discussion
 
 
						
9:20 pm - 9:30 pm 
	
Closing Remarks
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure