Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Vascular Signaling Networks in Development and Disease
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Arterial-Venous Programming in Development and Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"VEGF-B: The Yin and Yang in Angiogenesis"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Neural Progenitor Cell-Mediated Spatiotemporal Control of Spinal Cord Vascularization"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Energy Substrate Partitioning and Regulation in Endothelial Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signalling to Limit Specification of the Lymphatic Lineage"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Vascular Specification and Guidance and Organ-Specific Vasculature
New cellular and molecular mechanisms responsible for vascular guidance and specification will be presented. Specific attributes of blood vessels organization in various organs will be discussed.
9:00 am - 9:20 am
"Neurovascular Communication During CNS Development"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Guidance of Vascular Barrier Formation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Organotypic Differentiation, Regeneration and Angiocrine Functions of the Liver Vasculature"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Specification of Hematopoietic Stem Cells from Hemogenic Endothelium"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
"MicroRNA-223 Establishes a Specialized Glycome that Limits Hematopoietic Stem Cell Production from Endothelium"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Mechanosensory Function of Kindlin3 in Microglia Is Crucial for Retinal Vascular Patterning"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Neural JNK3 Regulates Blood Flow Recovery After Hindlimb Ischemia in Mice via an Egr1/Creb1 Axis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammatory Networks and Vascular Niche
7:30 pm - 7:50 pm
"Inflammation in the Vascular Wall"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Dendritic Cells in Vascular and Lymphatic Biology"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Early Vascular Development in Zebrafish and Mouse"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"The Functional Contribution of Endothelial-to-Mesenchymal Transition to Organ Fibrosis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Endothelial Pannexin1-Purinergic Signaling Axis Is a Key Regulator of the Cerebral Ischemic Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Dynamic Stroma Reorganization Drives Blood Vessel Dysmorphia During Glioma Progression: A Role for SLIT-ROBO Vascular Guidance Pathway"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology of Vascular and Lymphatic Systems
9:00 am - 9:20 am
"Systems Approach of Flow Regulation of KLF4-ITPR3 Axis in Endothelium"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Shear Stress Activation of the Klf2 Pathway"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Human Genetics in Vascular Mechanotransduction and Metabolism"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Directional Migration of Immune Cells: Chemokine Gradients, Traction Forces and Upstream Control"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Development and Maintenance of Organ-Specific Lymphatic Vasculature"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Differentiation of Endothelial Cells and Establishment of Organ-Specific Vessels"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Focal Adhesion EphA2 Signaling Promotes Contractility to Drive Fibrillar Adhesion Formation and Fibronectin Deposition"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Opposing Functions of Beta1-Integrin in Control of Vascular Integrity and Inflammation-Induced Leakage"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Regulatory Circuits in Vascular Development and Pathologies: Microvasculature and Long Non-Coding RNAs
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Transcriptional and Epigenetic Alterations in Endothelium Post-S1P Receptor Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Long Non-Coding RNAs in Vasculature"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Impact of Clonal Hematopoiesis in Vascular Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Prion-Mediated Activation of Endothelial Cell Signaling Networks in Brain Development and Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Combinatorial Roles of TCF7L2 and GATA6 in Vascular Smooth Muscle Differentiation and Prevention of Intimal Hyperplasia"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Recent Advances in Vascular Engineering, Targeting and Imaging
9:00 am - 9:20 am
"Imaging Neurovascular Interactions in Disease"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Targeted Cas9 Nanomedicines and DNA Barcodes"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Microengineered Human Blood Vessel for Next Generation Drug Discovery"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Tissue Specific Vascular Endothelium Contribute to Organotropic Metastasis"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Blood Vessel Regression in Adult Mammalian Brains"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Endothelial Cell Expressed Piezo1 Regulates Pressure-Induced Lung Vascular Permeability"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Foxc1 Regulation of mTOR Signaling During Physiological and Pathological Postnatal Retina Angiogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Age-Dependent Modulation of the Human Skin Microvasculature by Microenvironment and Serum"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Vascular Cell Fate and Disease
7:30 pm - 7:50 pm
"Perivascular Cells Are a Novel Source of Tissue Resident M2 Macrophages Important in Regulation of Vascular Integrity and Tissue Metabolism"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Regulation of Vascular Permeability"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Molecular Heterogeneity and Functional Specialization of Vascular Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"NCK-Dependent Pericyte Migration Promotes Pathological Neovascularization in Ischemic Retinopathy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Genetic Inactivation of the Pluripotency Factor OCT4 Within Endothelial Cells Leads to Enhanced Atherosclerosis in Apoe-/- Mice"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Integrin-Specific Signaling Drives ER Stress to Promote JNK Signaling and Atherogenic Endothelial Activation"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Control of Vasculature and Blood Vessels in Metabolic Diseases
9:00 am - 9:20 am
"Endocrine Function of Endothelium in Metabolism and Inflammation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Control of Perivascular Adipose Tissue Development and Thermogenesis by Early B Cell Factor 2"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Molecular and Therapeutic Aspects of Blood-Brain Barrier Regulation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Dual Roles of PKM2 in Endothelial Cell Proliferation and Vascular Permeability"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Myeloid Cells in Vasculature"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Reducing VEGF-B Signalling Ameliorates Hepatic Steatosis and Prevents Development of Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Exercise Promotes White Adipose Tissue Angiogenesis and Protects from Diet-Induced Metabolic Defects"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"PGC-1a/ARHGAP6 Axis Mediates Diabetic Vascular Dysfunction Through Diminution of Endothelial Glycolytic Flux"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Organ-Specific Heterogeneity in Endothelial Cell Hypoxia Response"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Vascular Inflammation and Aging
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Mitochondrial Control of Inflammation: Positive and Negative Control of the NLRP3 Inflammasome"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:20 pm
Introduction by Discussion Leader
8:20 pm - 8:45 pm
"PAD4: The Nuclear Button of Inflammation and Aging"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure