Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
7:40 pm - 9:30 pm 
	
Vascular Heterogeneity and Development 
 
 
 
						
7:40 pm - 8:00 pm 
	
"Endothelial Heterogeneity in Development and Tumour Angiogenesis" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:30 pm 
	
"Macrophage-Endothelial Cross Talk in Tissue Vascularization" 
 
 
 
						
8:30 pm - 8:40 pm 
	
Discussion
 
 
						
8:40 pm - 9:00 pm 
	
"Cell Fate Specification During Blood Vessel Development and Organogenesis" 
 
 
 
						
9:00 pm - 9:05 pm 
	
Discussion
 
 
						
9:05 pm - 9:25 pm 
	
"A Transcriptional Regulatory Logic for Pericyte Heterogeneity" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Mechanobiology and Bioengineering 
 
 
 
						
9:00 am - 9:20 am 
	
"Endoglin Signaling Controls Endothelial Cell Shape Differences Between Arteries and Veins" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Flow-Activated Pathways Reversing Endothelial Cell Dysfunction" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Contribution of Mechanical Forces From Blood Flow in Neurovascular Aneurysmal Malformations" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"High Fluid Shear Stress Induces Outward Remodeling Through a KLF2-BMPER Pathway" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"The Moonlighting Mechanosensor" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Vascular Mechanobiology: Learning from Engineered Blood Vessels" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Protocadherin Gamma Flow Signaling as Therapeutic Target in Atherosclerosis" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"Lung Mesenchymal Vascular Progenitors Modulate Adaptive Angiogenesis in Chronic Lung Disease" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Vascular Complications of Pregnancy 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Vascular Mechanisms for Preeclampsia and Related Disorders" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"Lymphatic Mimicry at the Maternal-Fetal Interface" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:50 pm 
	
"Leveraging Nature’s Success: Lessons from Modifiers of Marfan Syndrome and Related Aneurysm Conditions" 
 
 
 
						
8:50 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:20 pm 
	
"New Insights into Placental Vascular Growth and Function" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
 
 
						
9:00 am - 9:20 am 
	
"New Opportunities for Anti-Angiogenesis in Cancer" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Skeletal Muscle Endothelial Dysfunction in Cancer Cachexia" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Obesogenic Diet Promotes Endothelial-to-Mesenchymal Transition in Adipose Tissue" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Endothelial Metabolism in Tumor Immunity and Resistance to Immunotherapy" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"Long-range Endothelial Cell Junction Regulation Via Nuclear SUN1" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Oxidative Stress and Innate Immunity in Vascular Pathologies and Aging" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"A Human Vascular Differentiation Roadmap Reveals Unexpected Venous Origins and Target Cells of Deadly Viruses" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
 
 
						
7:30 pm - 7:50 pm 
	
"Chylomicrons, Endothelial Cells, and the Atherogenicity of Postprandial Lipemia" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"Endothelial Metabolism in the Muscle" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:50 pm 
	
"Endothelial Lipids and Blood Pressure" 
 
 
 
						
8:50 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Fatty Acid-binding Proteins Promote Endothelial Glycolysis and Arterial Programming" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Thrombolytic tPA-induced Intracerebral Hemorrhage in Ischemic Stroke is Mediated by Increased Adipose Tissue Lipolysis" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Development and Disease in the Cardiovascular Tree 
 
 
 
						
9:00 am - 9:20 am 
	
"Metabolic Fitness and the Competitive Vascular Zonation of Endothelial Cells" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"An Enhancer-based Approach to Studying Vessel Development" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Endothelial Cell Mitochondria and Sex Differences in Atherosclerosis" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"High-throughput CRISPR Screening Links CAD Loci to Endothelial Cell Programs and Causal Pathways" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"Cardiooncology through the Lens of Vascular Biology" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Leveraging Human Genetics to Develop Drugs that Address Residual Risk of CV Events" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Global Inhibition of Myeloperoxidase Improves Survival in a Novel Mouse Model of Coronary Atherosclerosis, Spontaneous Myocardial Infarction and Stroke" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"PRDM6 Regulates the Embryonic Differentiation of Renin-producing Cells into Vascular Smooth Muscle Cells and its Altered Function Causes Hypertension" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Vascular Metabolism and Pulmonary Disease 
 
 
 
						
7:30 pm - 7:40 pm 
	
Introduction by Discussion Leader
 
 
						
7:40 pm - 8:00 pm 
	
"Multi-dimensional -omics Analyses Reveal Novel Metabolic Mechanisms of Endothelial Dysfunction in Pulmonary Hypertension" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:30 pm 
	
"Dysfunctional Angiogenesis in Pulmonary Arterial Hypertension: The Role of Wnt Signaling Pathways" 
 
 
 
						
8:30 pm - 8:40 pm 
	
Discussion
 
 
						
8:40 pm - 8:50 pm 
	
"Alternative Polyadenylation Leads to 3’UTR Shortening of Prostaglandin E3 Receptor and Increased RUNX1 Expression in Pulmonary Arterial Hypertension" 
 
 
 
						
8:50 pm - 8:55 pm 
	
Discussion
 
 
						
8:55 pm - 9:05 pm 
	
"Intermediate States in Pulmonary Fibrosis Are Associated With Metabolic Shifts in Cellular Reprogramming" 
 
 
 
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:30 pm 
	
General Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s) 
 
 
						
9:00 am - 12:30 pm 
	
Vessels and Neurovascular Disease 
 
 
 
						
9:00 am - 9:20 am 
	
"The Intra and Intercellular Communication at the Blood-Brain Barrier" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Molecular Anatomy of Blood Vessels and Vessel-associated Structures" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"The Role of Neuroendothelial Cells in Organ Blood Flow Regulation" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Mesenchymal mTOR Activation Contributes to Pulmonary Vascular Remodeling Through Dysregulation of Vascular Endothelial Cells" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"The Vascular Endothelium in Development and Beyond" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Vascular Dysfunction in the Kidney" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"RNA Surveillance by ADAR1 is Required for Vascular Endothelial Resilience" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"m6A RNA Methylation is Integral for the Maintenance of Vascular Endothelial Cell Resilience" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
 
 
						
7:30 pm - 7:50 pm 
	
"Undoing Loss of Microvascular Homeostasis Promotes Healthy Aging" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:10 pm 
	
"Age of the Bone Marrow Dictates Clonality of Smooth Muscle-derived Cells in the Atherosclerotic Plaque" 
 
 
 
						
8:10 pm - 8:15 pm 
	
Discussion
 
 
						
8:15 pm - 8:35 pm 
	
"Cerebromicrovascular Senescence in Aging" 
 
 
 
						
8:35 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 9:05 pm 
	
"Endothelial Diversity: Cell Type-specific Signaling" 
 
 
 
						
9:05 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:30 pm 
	
General Discussion
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure