Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Legacy Effects in Clinical Management of Diabetes
Discussion Leader: Paul Zimmet (Central Clinical School, Monash University, Australia)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Trevor Orchard (University of Pittsburgh, USA)
"Emerging Epidemiological Insights in the Development of Diabetic Complications"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Rury Holman (University of Oxford, United Kingdom)
"Legacy Effects in the UKPDS Type 2 Diabetes"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Wide Association Studies of Diabetic Complications
Discussion Leader: Nelson Tang (Chinese University of Hong Kong, Hong Kong SAR China)
9:00 am - 9:30 am
Leif Groop (Lund University, Sweden)
"Genome Wide Association Studies for Diabetic Complications - Insights from SUMMIT"
9:30 am - 9:50 am
Discussion
9:50 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 11:00 am
Yuk-Lap Yip (The Chinese University of Hong Kong, Hong Kong SAR China)
"Epigenetic Markers of Diabetic Complications"
11:00 am - 11:20 am
Discussion
11:20 am - 11:50 am
Paul Franks (Lund University Diabetes Centre, Sweden)
"Lifestyle in the Context of Precision Diabetes Medicine"
11:50 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Application of Multiomic Approaches in the Study of Diabetic Complications
Discussion Leader: Simin Liu (Brown University, USA)
7:30 pm - 8:00 pm
Mark McCarthy (University of Oxford, United Kingdom)
"Combining Large-Scale Human Genetics with Epigenomic Annotation to Inform Type 2 Diabetes Biology"
8:00 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Daniel Levy (National Heart, Lung, and Blood Institute, NIH, USA)
"Network Analyses of Cardiovascular Disease"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Chin Yee Ho (King's College London, United Kingdom)
"Epigenetic Regulation of Vascular Calcification"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Parental Transmission of Disease Risk to Offspring
Discussion Leader: Rebecca Simmons (University of Pennsylvania, USA)
9:00 am - 9:30 am
Qing-Yuan Sun (Chinese Academy of Sciences, China)
"Transgenerational Inheritance of Susceptibility to Diabetes"
9:30 am - 9:50 am
Discussion
9:50 am - 10:20 am
Coffee Break
10:20 am - 10:50 am
Marika Charalambous (King's College London, United Kingdom)
"Genomic Imprinting: Adiposity and Pregnancy"
10:50 am - 11:10 am
Discussion
11:10 am - 11:25 am
Selected from Poster Abstracts: Cynthia Jiang (The Chinese University of Hong Kong, Hong Kong SAR China)
"Heterochromatin Condensation Is Mediated by Jmjd1a and Jmjd2c During Physiological Stem Cell Aging"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Ishant Khurana (Monash University, Australia)
"Cytosine Methylation Is Associated with the Development of Diabetic Complications"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Neil Youngson (UNSW Sydney, Australia)
"Is De Novo DNA Methylation Required for Normal Liver Metabolism and Obesity-Induced Liver Disease?"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Mark Pepin (University of Alabama at Birmingham, USA)
"Epigenetic Programming in Diabetic End-Stage Failing Human Heart"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
Non-Coding RNAs in Diabetes
Discussion Leader: Rama Natarajan (Beckman Research Institute of City of Hope, USA)
4:00 pm - 4:30 pm
Yu Huang (Chinese University of Hong Kong, Hong Kong SAR China)
"MicroRNAs in Endothelial Function and Dysfunction"
4:30 pm - 4:50 pm
Discussion
4:50 pm - 5:20 pm
Romano Regazzi (University of Lausanne, Switzerland)
"Micro-RNAs and the Diabetic β-Cell"
5:20 pm - 5:40 pm
Discussion
5:40 pm - 5:55 pm
Selected from Poster Abstracts: Mohamed Noureldein (American University of Beirut, Lebanon)
"Role of Gut Microbiota on Mediating Diabetic Complications: Epigenomics Perspective"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics of Diabetic Complications
Discussion Leader: George King (Joslin Diabetes Center, USA)
9:00 am - 9:30 am
Adam Wende (University of Alabama at Birmingham, USA)
"Glucose-Mediated Remodeling of Cardiac DNA Methylation"
9:30 am - 9:50 am
Discussion
9:50 am - 10:20 am
Coffee Break
10:20 am - 10:50 am
Karl Bacos (Lund University, Sweden)
"DNA Methylation Changes in Human Islets"
10:50 am - 11:10 am
Discussion
11:10 am - 11:40 am
Rama Natarajan (Beckman Research Institute of City of Hope, USA)
"DNA Methylation and Metabolic Memory in the DCCT/EDIC Type 1 Diabetes Cohort"
11:40 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Alfred Cheng (School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR China)
"Epigenetics and Immunotherapy in Diabetes-Associated Hepatocellular Carcinoma"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Preclinical and Human Epigenetics
Discussion Leader: Stephan Beck (University College London, United Kingdom)
7:30 pm - 8:00 pm
John Pospisilik (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Bi-Stable Epigenetic Obesity"
8:00 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Andrew Feinberg (Johns Hopkins University School of Medicine, USA)
"Epigenetic Approaches Identifying Functional Genes"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Antony Kaspi (Monash University, Australia)
"Diet During Pregnancy Regulates Hypothalamic DNA and RNA Methylation and Risk of Obesity in Offspring"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Emerging Concepts of Epigenetic Memory in Metabolic Disease
Discussion Leader: Peter Jones (University of Nevada, Reno School of Medicine, USA)
9:00 am - 9:30 am
Peter Jones (University of Nevada, Reno School of Medicine, USA)
"Facioscapulohumeral Muscular Dystrophy as a Model for Epigenetic Regulation and Disease"
9:30 am - 9:50 am
Discussion
9:50 am - 10:20 am
Coffee Break
10:20 am - 10:50 am
Rebecca Simmons (University of Pennsylvania, USA)
"Emerging Epigenetic Mechanisms in Metabolic Disease Risk"
10:50 am - 11:10 am
Discussion
11:10 am - 11:40 am
Niels Riksen (Radboud University Medical Centre, The Netherlands)
"Epigenetics and Trained Immunity"
11:40 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Therapeutic Strategies in Diabetic Complications
Discussion Leader: Mark Cooper (Monash University, Australia)
4:00 pm - 4:30 pm
Hui-Yao Lan (Chinese University of Hong Kong, Hong Kong SAR China)
"Non-Coding RNAs as a Therapeutic Strategy for Diabetic Nephropathy"
4:30 pm - 4:45 pm
Discussion
4:45 pm - 5:15 pm
Patrick Collombat (INSERM U1091, France)
"Induction of Pancreatic β-Like Cell Neogenesis"
5:15 pm - 5:30 pm
Discussion
5:30 pm - 5:45 pm
Selected from Poster Abstracts: Abdul Khan (Karolinska Institute, Sweden)
"Epigenetic Repression of Jund Is Associated with Myocardial Dysfunction in Diabetes"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:00 pm
Closing Remarks
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure