Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Glial-Glial Interactions in Myelination
Discussion Leader: Patrizia Casaccia (Advanced Science Center, City University of New York, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Mikael Simons (Technical University, Munich, Germany)
"Innate Immune Mechanisms in Remyelination"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Kelly Monk (Oregon Health and Science University, United States)
"An Fbxw7/Myrf Axis Regulates the Extent of Myelination in the CNS"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Ye Zhang (University of California, Los Angeles, United States)
"The Role of Exocytosis in Oligodendrocyte Development and Myelination"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Monique Lillis (University of California, San Francisco, United States)
"The Diverse Roles of Extracellular Matrix on the Form and Function of Schwann Cells"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Glial-Glial Interactions in Injury and Disease
Discussion Leaders: Veronique Miron (University of Toronto , Canada) and Voon Wee Yong (University of Calgary, Canada)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Dorothy Schafer (University of Massachusetts Chan Medical School, United States)
"Microglia and Circuit Dysfunction in Demyelinating Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Brian Popko (Northwestern Feinberg School of Medicine, United States)
"Oligodendroglial Responses in Vascular Dementia"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Mengsheng Qiu (Hangzhou Normal University, China)
"Autonomous Regulation of Oligodendrocyte Proliferation and Differentiation"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Sarah Kucenas (University of Virginia, United States)
"Mechanisms of Myelin Targeting in the Developing CNS"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Joseph Gallegos (University of Pennsylvania, United States)
"Absence of TNFa, IL-1a, and C1q, Impairs Cortical Oligodendrocyte Recovery Following Demyelination"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Clément Perrot (ICM, France)
"Neuronal Activity Modulates Microglia Phenotype in Repair through Microglia-Node of Ranvier Interaction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Michael Stockton (University of Colorado Anschutz Medical Campus, United States)
"Quiescence Determines Survival of Differentiating OPCs in Health and Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kristina Battis (Univeristy Hospital, Erlangen, Germany)
"Intracellular A-Synuclein Impairs Myelinogenesis Due to Dysregulated Actin Remodeling and Lipid Metabolism of Human-Induced Oligodendrocytes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Dorothy Schafer (University of Massachusetts Chan Medical School, United States) and Katrina Adams (University of Notre Dame, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuronal to Glial Interactions in Myelination
Discussion Leaders: Eva-Maria Krämer-Albers (Johannes Gutenberg University, Mainz, Germany) and Kaylene Young (University of Tasmania, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Wendy Macklin (University of Colorado School of Medicine, United States)
"Axonal Signaling Regulating Oligodendrocyte Differentiation"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Erin Gibson (Stanford University School of Medicine, United States)
"Temporal Dynamics of Oligodendroglial Lineage Cells"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Lu Sun (University of Texas Southwestern Medical Center, United States)
"Axons Fine-Tune Myelination by Suppressing an Inhibitory Transcription Network in Oligodendrocytes"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Nuria Dominguez Iturza (Harvard University, United States)
"Molecular Mechanisms Governing Projection-Neuron-Specific Myelination in the Cortex"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Cristobal Ibaceta Gonzalez (Institute of Psychiatry and Neuroscience of Paris, France)
"Early Neuron-Oligodendroglia Communication Impacts Prefrontal Oscillations and Fear Extinction"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Lacey Sell (University of Texas Health Science Center San Antonio, United States)
"Structural and Functional Insights Into Human CNTNAP1 Mutations and Molecular Organization of Axonal Domains in Myelinated Axons"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neuronal to Glial Interactions in Injury and Disease
Discussion Leaders: Julia Edgar (University of Glasgow, United Kingdom) and Ben Emery (Oregon Health and Science University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Martin Kerschensteiner (University Hospital, Ludwig Maximilian, Munich, Germany)
"Contribution of Surviving Oligodendrocytes to Myelin Repair in the Inflamed Cortex"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Clemence Blouet (University of Cambridge, United Kingdom)
"Oligodendrocyte and Myelin Turnover in the Median Eminence: An Adaptive Mechanism for Metabolic Plasticity"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Robert Hill (Dartmouth College, United States)
"The Death of an Oligodendrocyte"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Yu Kang Xu (Johns Hopkins School of Medicine, United States)
"Defining the Myelinome: A Brain-Wide Map of Oligodendrocyte Distribution and Myelin Patterning in Health and Disease"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Leslie Kirby (Karolinska Institutet, Sweden)
"Spatially Resolved Tri-Omic Profiling of the Dynamics of Oligodendrocyte Development, Demyelination and Remyelination"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Olamide Adebiyi (Western University, Canada, Canada)
"Chemogenetic Activation of Hippocampal CAMKiia-Expressing Neurons Accelerates Remyelination and Improves Cognition in Lysolecithin-Induced Demyelination"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Aksheev Bhambri (University of Texas Southwestern Medical Center, United States)
"Genetically Labelled Premyelinating Oligodendrocytes Reveal Multi-Faceted Effect of Neuronal Activity on Oligodendrocyte Differentiation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Tal Iram (Stanford University, United States)
"SRF Transcriptionally Regulates the Oligodendrocyte Cytoskeleton During CNS Myelination"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Mary-Amélie Masson (Paris Brain Institute, France)
"A Role for the Post-Synaptic Density Protein PSD-95 in CNS Myelination"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glial to Neuronal Interactions in Myelination
Discussion Leaders: Dies Meijer (University of Edinburgh, United Kingdom) and Dies Meijer (University of Edinburgh, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Laurent Nguyen (University of Liege, Belgium)
"Neuron-Glia Crosstalk Shapes Brain Morphogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Yael Eshed-Eisenbach (Weizmann Institute of Science, Israel)
"Regulation of Gliomedin is Critical for Normal Peripheral Nerve Excitability"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
James Salzer (New York University School of Medicine, United States)
"Schwann Cell Regulation of the Neuronal Phenotype: Insights from Myelin Mutants"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Carmen Melendez-Vasquez (Hunter College, City University of New York, United States)
"Stiffening of the Chronically Demyelinated CNS and its Contribution to Remyelination Failure"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glial to Neuronal Interactions in Injury and Disease
Discussion Leaders: Ethan Hughes (University of Colorado School of Medicine, United States) and Tara DeSilva (Cleveland Clinic, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Klaus-Armin Nave (Max Planck Institute for Multidisciplinary Sciences, Germany)
"Oligodendrocytes in Axonal Energy Metabolism and Neurodegenerative Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Matthew Rasband (Baylor College of Medicine, United States)
"Building and Maintaining a Node of Ranvier"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Sonia Mayoral (Brown University, United States)
"Local Oligodendroglial Impacts on Axon Degeneration"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Cristin Welle (University of Colorado School of Medicine, United States)
"Myelin Drives Precise Neural Connectivity and Reliability in Motor Cortex for Accurate Skilled Reaching"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Ahmed Abdelhak (University of California, San Francisco, United States)
"Acute and Chronic Demyelination Independent of Inflammation Promotes Tissue and Blood Markers of Neuroaxonal Pathology"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Ligia Schmitd (University of Michigan Medical School, United States)
"Regulates Schwann Cell Reprograming and Timely Nerve Regeneration"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Greg Duncan (Oregon Health and Science University, United States)
"Remyelination Protects Neurons from Dual Leucine Zipper Kinase-Mediated Neurodegeneration"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Joseph Barnes-Velez (Monroe Dunaway Anderson Cancer Center, University of Texas, United States)
"Sphingolipid Dysmetabolism is a Candidate Driver of Demyelination and Axonal Dysfunction in Both Quaking Depleted and Injured Nerves"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamism in Adult Myelin
Discussion Leaders: Bruce Appel (University of Colorado Anschutz Medical Campus, United States) and Tim Czopka (University of Edinburgh, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Dwight Bergles (Johns Hopkins University School of Medicine, United States)
"Myelin Repair through Stochastic Differentiation of Oligodendrocyte Precursor Cells"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Michelle Monje (Stanford University, United States)
"Adaptive and Maladaptive Myelination"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Wendy Xin (University of California, San Francisco, United States)
"Adolescent Oligodendrogenesis and Myelination Restrict Experience-Dependent Neuronal Plasticity in Adult Visual Cortex"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Marie Mather (New Jersey Medical School, Rutgers University , United States)
"Regional Differences in Oligodendroglial Cholesterol Acquisition and Myelin Lipid Composition"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Yifei Cai (Yale University, United States)
"Myelin-Axon Interface Vulnerability Uncovered by Subcellular Proteomics and Imaging of Alzheimer’s Human Brain"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Session in Memory of Laura Feltri: Myelin Developmental and Genetic Disorders
Discussion Leaders: Vittorio Gallo (Seattle Children's Hospital, United States) and Carla Taveggia (San Raffaele Scientific Institute, Italy)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Bridget Ostrem (University of California, San Francisco, United States)
"Harnessing the Pro-Myelinating Potential of Human Breast Milk Compounds for Remyelination After Chronic Hypoxia"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Evan Goldstein (Augusta University, United States)
"Molecular Mechanisms of Neonatal Brain Injury and Enrichment-Induced Recovery"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Alessandra Bolino (Vita-Salute San Raffaele University, Italy)
"Myotubularin-Related (MTMR) Phosphoinositide Phosphatasesand Inherited Neuropathies"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
Lydia Daboussi (University of California, Los Angeles, United States)
"Peripheral Nerve Repair During Neurodegenerative Disease"
11:00 am - 11:05 am
Discussion
11:05 am - 11:20 am
Violetta Zujovic (ICM, France)
"Multiple Sclerosis Patient Lymphocytes Induce Smoldering Like Demyelinating Lesion in Mouse Spinal Cord"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Shuo-Chien Ling (National University of Singapore, Singapore)
"Deciphering TDP-43 Functions in Myelinating Oligodendrocytes and Schwann Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Nour Jabassini (University of California, San Francisco, United States)
"Sialic Acid Transport is Necessary for Developmental Myelination"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jun Yup Lee (University of Sydney, Australia)
"APOE Regulates Myelin Lipid Turnover in Healthy Brains"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Lindsay Festa (University of Pennsylvania, United States)
"TRPML1 is a Novel Regulator of the Oligodendrocyte Cytoskeleton"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Myelin and Behavior
Discussion Leader: David Lyons (University of Edinburgh, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
William Richardson (University College London, United Kingdom)
"Is Generation of Compact Myelin Required for Learning and Memory Formation?"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Jia Liu (Advanced Science Research Center, City University of New York, United States)
"The Environmental Impact on Psychiatric Disorders Through Oligodendrocyte Function"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Boaz Barak (Tel Aviv University, Israel)
"Shank3 Mutation Impairs Oligodendroglial Glutamatergic Properties and Myelin Development in ASD"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Alejandro Lopez-Juarez (University of Texas Rio Grande Valley, United States)
"Neurofibromatosis Type 1 Mutation in Mice Impacts Myelin Biology in the Short and Long-Term in Correlation With Progressive Learning Abnormalities"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Albert Zhang (University of California, San Francisco, United States)
"A Shock to Remember: Investigating the Where and When of Myelination During Fear Learning"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure