Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Cell Death Mechanisms
Discussion Leader: Shannon Hughes (NIH/NCI, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Justin Pritchard (The Pennsylvania State University, United States)
"Engineering Signal Transduction to Create "Dual Switch Selection Gene Drives""
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Cornelius Taabazuing (University of Pennsylvania, United States)
"New Insights into Pyroptotic Cell Death"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Michael Overholtzer (Memorial Sloan Kettering Cancer Center, United States)
"Regulated Cell Death in Development and Disease: Focus on Population Dynamics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism in Engineered Microenvironments
Discussion Leader: Claudia Fischbach (Cornell University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Gaudenz Danuser (UT Southwestern Medical Center, United States)
"The Roles of Cell Shape in Signal Transduction"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Andreas Stahl (UC Berkeley, United States)
"Biomechanical Signals in Brown Fat Activation"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Catherine K. Kuo (University of Maryland, United States)
"Mechanomodulating Developing Microenvironments to Discover Regenerative Therapeutic Targets"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Beth Pruitt (University of California, Santa Barbara, United States) and Kelly Stevens (University of Washington, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
ECM Drivers of Cellular Quiescence, Senescence, and Stress
Discussion Leader: Stelios Andreadis (University at Buffalo, SUNY, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Cyrus Ghajar (Fred Hutchinson Cancer Center, United States)
"The Skeletal Muscle as a Paradigm for Metastasis Suppression"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Janine Erler (University of Copenhagen, Denmark)
"ECM Regulation of Metastatic Tumour Growth"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Kandice Tanner (NIH, United States)
"Multimodal Interrogation of the Organ Microenvironment"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reporters of Cell-ECM Signaling
Discussion Leader: Brenton Hoffman (Duke University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Wendy Gordon (University of Minnesota, United States)
"High-Throughput Molecular Tension Sensors to Probe Cell-ECM Interactions"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Peter Yingxiao Wang (University of Southern California, United States)
"Mechanogenetics for Cell ImmunoTherapy"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
David Schaffer (University of California, Berkeley, United States)
"Engineering Biomaterial Microenvironments to Scale Stem Cell Expansion and Differentiation for Clinical Translation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex and Ancestry in Cell-ECM Signaling
Discussion Leader: Brendan Harley (University of Illinois, Urbana Champaign, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Erika Moore (University of Maryland, College Park, United States)
"Engineered Extracellular Matrices for Macrophage Insights in Tissue Regeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Brian Aguado (University of California San Diego, United States)
"Determining Sex Chromosome Regulation of Cardiovascular Diseases using Engineered Extracellular Matrices"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Justin Lathia (Cleveland Clinic Foundation, United States)
"Glioblastoma Sex Differences in Immune Responses Reveal Cell Adhesion Differences that Impact Tumor Growth"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Dynamic, Responsive, and Living Materials
Discussion Leader: Jennifer Munson (Virginia Tech, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Molly Shoichet (University of Toronto, Canada)
"Engineered ECM for Novel Target Discovery in Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Late-Breaking Topic
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Aaron Esser-Kahn (University of Chicago, United States)
"Adaptive Materials via Mechanically Mediated Chemical Reactions"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Kevin Healy (University of California, Berkeley, United States)
"4D Hydrogels for Regenerative Medicine"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Late-Breaking Topic
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamics and Turnover of Engineered ECMs
Discussion Leader: Andres Garcia (Georgia Institute of Technology, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Manu Platt (National Institutes of Health, United States)
"Powers (and Problems) of Proteolytic Activity in ECM Turnover: A Systems Approach"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Edna Cukierman (Fox Chase Cancer Center, United States)
"The CAF/ECM Unit Maestro: Decoding Pancreatic Cancer's Melody via H armonic O utput of S tromal T raits (HOST)-Factor"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Claudia Loebel (University of Michigan, United States)
"Engineering the Cell-Matrix Interface to Probe Stem Cell Function"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Multiscale Modeling in Cell-Matrix Mechanobiology
Discussion Leader: Vivek Shenoy (University of Pennsylvania, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
David Odde (University of Minnesota, United States)
"Motor-Clutch Dynamics of Glioblastoma Cell Migration in Brain Tissue"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Amit Pathak (Washington University in St Louis, United States)
"Role of Microenvironment Memories in Cell Migration"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Ulrich Schwarz (Heidelberg University, Germany)
"Controlling Cell Contractility through the Rho-Pathway: Insights from Optogenetics and Mathematical Modelling"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microphysiological Systems
Discussion Leader: Steven George (UC Davis, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Shyni Varghese (Duke University, United States)
"Vascularized Lung-Cancer Organoid towards Enabling Therapeutics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Sam Senyo (Case Western Reserve University, United States)
"Tissue Engineering Approach to Defining Exercise Molecular Cues"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Wilbur Lam (Emory University/Georgia Tech, United States)
"Exploring the Links between Hematologic Disease and Endothelial Mechanotransduction Using Engineered Microsystems"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure