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Advanced Cell and Tissue Biomanufacturing

Gordon Research Conference

Accelerating Cell and Tissue Manufacturing Technology Development and Innovation Through Convergence

June 25 - 30, 2023

Chairs Kaiming Ye and Paul Carlyle. Goodwin

Vice Chairs Gang Bao and Jay Hoying

Grand Summit Hotel at Sunday River

97 Summit Road

Newry, Maine, United States

Venue and Travel Information

Conference Description

The Advanced Cell and Tissue Biomanufacturing GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The advances in tissue engineering, regenerative medicine, and additive manufacturing enables the generation of various therapeutic cells and tissues for disease diagnosis, treatment, prevention, and management. A robust, reliable, scalable manufacturing process has now become a serious obstacle to launching the industry needed to deploy these innovations. The conference will converge academic forces with industry niches to identify gaps and challenges that will stimulate new science and technology innovation for the field. The goal is to offer a platform to evoke productive collaborations and partnerships.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Manufacturing Cell and Tissue Products at Scale Discussion Leader: Rosemarie Hunziker (Advanced Regenerative Manufacturing Institute, United States)
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:15 pm	Jan Jensen (Trailhead Biosystems, United States) "Building a Comprehensive Approach to Cell Manufacturing where we Address Biology by Mathematics, rather than Hypotheses"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:00 pm	Matt Udelhofen (Humacyte, Inc. , United States) "A Modular Platform for Commercial Biomanufacturing of Human Acellular Vessels (HAVs)"
9:00 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell and Material Sourcing Discussion Leader: Gang Bao (Rice University, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	David Kaplan (Tufts University, United States) "Biomaterial Challenges for Future Foods"
9:35 am - 9:50 am	Discussion
9:50 am - 10:20 am	Mark Powers (Thermo Fisher Scientific, United States) "Cell Culture Systems: Development, Transfer and Commercialization for Cell and Tissue Biomanufacturing"
10:20 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:35 am	Sean Palecek (University of Wisconsin - Madison, United States) "Identification of Features Predicting Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes via Multi-omics Analysis"
11:35 am - 11:50 am	Discussion
11:50 am - 12:00 pm	General Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer: Tracy Hookway (The Research Foundation, SUNY, United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Process Modeling, Simulation, and Scale-Up/Out Discussion Leader: Pinar Zorlutuna (University of Notre Dame, United States)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	John Wikswo (Vanderbilt University, United States) "Genesis -- A Massively Parallel Robot Scientist Operating as a Self-Driving Biological Laboratory to Accelerate Clonal Selection, Deconvolve Bioreactor Zonation, and Optimize iPSC and MSC Differentiation"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Emmanuel Tzanakakis (Tufts University, United States) "Stem Cell Population-Based Modeling for Biomanufacturing"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	Sakis Mantalaris (Trinity College Dublin , Ireland) "Improving Stem Cell Biomanufacturing Through Bioprocess Model Design"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Tissue Biofabrication Monitoring, Measurement, and Tools Discussion Leader: Jeffrey Halpern (University of New Hampshire, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	John Fisher (University of Maryland, United States) "3D Printing to Engineer Complex Tissues"
9:35 am - 9:45 am	Discussion
9:45 am - 10:15 am	Michael Golway (Advanced Solutions, Inc., United States) "Three Pillars of Automation that Enable Real-time Assessment of Tissue Maturation"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	Harihara Baskaran (Case Western Reserve University, United States) "Sensors for Non-Destructive Monitoring of Tissue Development"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	Akash Garg (Carnegie Mellon University, United States) "Freeform 3D Ice Printing (3D-ICE) at the Micro Scale for Advancing Biomanufacturing"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Kyung Jae Jeong (University of New Hampshire, United States) "A Novel 3D Printing Process for Enhanced Mechanical Properties of Tissue Engineering Scaffolds"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Industrial Scale Bioreactor Design and System Integration Discussion Leader: Tracy Hookway (The Research Foundation, SUNY, United States)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:05 pm	Thomas Bollenbach (Advanced Regenerative Manufacturing Institute, United States) "Multisystem Integration for Scalable, Consistent and Cost-Effective Manufacturing of Cells, Tissues and Organs"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:45 pm	Sarindr "Ik" Bhumiratana (EpiBone Inc, United States) "Development of Bioreactor for Tissue Biomanufacturing from Research to Clinic"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:10 pm	Yuguo Lei (The Pennsylvania State University, United States) "Microbioreactors for Mass Cell and Tissue Production"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Functional Determination and Readiness Assessment of Tissue Maturation Discussion Leader: Guohao Dai (Northeastern University, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	Hermann Haller (Mount Desert Biological Laboratory MDIBL, United States) "Vascularization of Organoids - the Elephant in the Room"
9:35 am - 9:45 am	Discussion
9:45 am - 10:15 am	Zhengpeng Wan (MIT, United States) "Strategies for Vascularising Complex Tissues In Vitro"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:25 am	Milica Radisic (University Health Network, Canada) "Advances in Vascularization of Tissues and Organs-on-a-Chip"
11:25 am - 11:35 am	Discussion
11:35 am - 11:50 am	Kayla Wolf (Harvard University, United States) "A Perfusable Ureteric Bud-on-Chip Model"
11:50 am - 11:55 am	Discussion
11:55 am - 12:10 pm	Yi Zheng (Syracuse University, United States) "Biomanufacturing of Microfluidic Amniotic Sac Embryoid using Human Pluripotent Stem Cells"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cell and Tissue Preservation, Logistics, and Distribution Discussion Leader: Richard McFarland (Advanced Regenerative Medicine Institute, United States)
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:10 pm	Mehmet Toner (Harvard and Massachusetts General Hospital, United States) "Different Strategies to Achieve Suspended Animation in Living Mammalian Cells and Tissues"
8:10 pm - 8:25 pm	Discussion
8:25 pm - 8:55 pm	Julie Allickson (Mayo Clinic, Center for Regenerative Biotherapeutics, United States) "Building the Ecosystem of Regenerative Biotherapeutics for Rare and Complex Disease"
8:55 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Regulation and Standardization of Tissue Biofabrication Discussion Leader: Warren Grayson (Johns Hopkins University, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	Carl Simon (NIST, United States) "A Metrological Perspective on Mechanism of Action and Potency for Cell-Containing Therapeutics"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Barbara Boyan (Virginia Commonwealth University, United States) "Modulating Cell and Tissue Formation via Substrate Surface Design in 2D and 3D"
10:05 am - 10:15 am	Discussion
10:15 am - 10:40 am	Coffee Break
10:40 am - 10:50 am	Zahraa Albeshir (University of New Hampshire, United States) "Investigating Surface Stability of Gold Surface Modifications"
10:50 am - 10:55 am	Discussion
10:55 am - 11:05 am	Eva Rose Balog (University of New England, United States) "On-Demand Protein Biosensors for Biomanufacturing: Engineering Principles for Analyte-Responsive Polymers"
11:05 am - 11:10 am	Discussion
11:10 am - 11:20 am	Michael Bukys (Trailhead Biosystems, United States) "The Industrialized Scaled Production of iPSC-Derived Pancreatic Islet-like Aggregates"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	Shaquielle Dias (Johns Hopkins School of Medicine, United States) "Storage of Electrospun Acellular Fibrin Microfiber Bundle Scaffolds"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	Christine McBeth (Fraunhofer USA Center for Manufacturing Innovation, United States) "Leveraging Textile Manufacturing to Build Tissue Scaffolds at Scale"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	Victoria Nash (Drexel University, United States) "Leveraging Biotin-Avidin as a Platform Technology to Customize Immunomodulatory Properties of Engineered Tissues"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Moving from the Bench to Bedside: Lessons Learned and the Promise of Regenerative Medicine Discussion Leader: Paul Goodwin (Cytiva, United States)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:05 pm	Beth Ripley (Veterans Health Administration, United States) "Point of Care BioFabrication of Patient-Matched Bone Grafts: the Veterans Health Administration’s Journey"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Warren Grayson (Johns Hopkins University, United States) "Facing the Future Tissue Engineering Treatment of Craniomaxi"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:15 pm	Jay Hoying (Advanced Solutions Life Sciences, United States) "Building Vasculatures in Facial Bone Injuries"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

MDI: Biological Laboratory

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