Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Novel Mechanisms of Multiple-Organ and Tissue Injury
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"Host-Microbiome Interactions in Alcohol-Associated Diseases"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Triggers, Pathways and Mediators of Alcohol-Induced Tissue Inflammation"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteostasis (Protein Homeostasis) in Alcohol-Induced Organ Injury
9:00 am - 9:20 am
"Autophagy, a Common Mechanism for Alcohol-Induced Liver and Pancreatic Injury"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Endoplasmic Reticulum Protein Processing with Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Precision Monitoring of Alcohol in Health and Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Establishment of a Cellular Model to Study Ethanol-Induced Lipophagy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Targeting Proteostasis Pathways: New Therapeutic Paradigm in Alcoholic Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanism of Skeletal Muscle Proteostasis and Sarcopenia in Alcoholic Liver Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Activation of mTORC1 Contributes to the Development of Alcoholic Liver Injury in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Vitamin D3 Upregulated Protein 1-Depdendant Autophagy and Fatty Acid Oxidation Attenuates Liver Steatosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol, Stem Cells, and Cancer
7:30 pm - 7:50 pm
"The Effects of Alcohol on Epithelial Stem Cells of the Oral Cavity and Esophagus During Carcinogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Aldehyde Dehydrogenases in Cancer Stem Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Cell Fate Decision and Metabolic Reprograming of Tumor-Initiating Stem-Like Cells in Alcohol-Associated Injury and Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Alcohol Modulates Hormonal and Oncogenic Signaling in Breast Cancer Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol Promotes Esophageal Tumor Growth by Enriching Cancer Stem Cells with a High Autophagy Capacity"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"IL-1 Receptor Like 1 (ST2) Protects Against Alcoholic Liver Injury and Inflammation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Caspase 11-Gasdermin-D Pathway in Alcoholic Hepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Molecular Mechanisms of Alcoholic Kidney Disease: Role of Neutrophils"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"MIF Inhibition Protects Hepatocytes from Ethanol-Induced Injury Independent of Neutrophil Accumulation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mesenteric Lymphatic/Perilymphatic Adipose Tissue Crosstalk: Mechanism of Alcohol Immunomodulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Alcohol Intoxication and the Pulmonary Inflammatory Response After Injury"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Hippo Signaling in Alcohol-Induced Multiple Organ Injury and Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Circulating Microbiome Changes Are Associated with the Development and Severity of Alcoholic Hepatitis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Coding RNA and Extracellular Vesicles
7:30 pm - 7:50 pm
"Extracellular Vesicles and Alcoholic Liver Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Non-Coding RNA as Novel Regulator of Alcoholic Fatty Liver"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Exosomes and TLR3 in Liver Fibrosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Let7/Lin28 Axis Regulates Activation of Hepatic Stellate Cells in Alcoholic Liver Injury"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"ER Stress-Dependent Release of Mitochondrial DNA Enriched Microparticles Contributes to Acute-on-Chronic Alcoholic Neutrophilia and Hepatotoxicity"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol, Gut Microbiota, Intestinal Barrier Function, and Fat Metabolism
9:00 am - 9:20 am
"Alcohol:Fat Interactions in the Development/Treatment of Alcoholic Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Adiponectin-FGF15/19 Signaling, a Pivotal Adipose-Gut-Liver Axis in Alcoholic Steatohepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"The Impact of Adiosity on Alcoholic Hepatitis: Just Enough Fat Is Good for You"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Absence of Perilipin 2 Prevents the Increase of Long-Chain Ceramides in the Lipid Droplet Fractions of Alcohol-Fed Mice"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Microbiota, Gut Leakiness to Endotoxins and Circadian Disruption in Alcohol Use Disorders"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Alcohol-SIV/HIV-ART Interactions Promote Metabolic Dysregulation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Targeting the Gut Microbial TMA-Lyase for the Treatment of Alcohol-Induced Liver Injury"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Impact of Chronic Ethanol Consumption on Pathophysiology and Mucosal Gene Expression of the Gastrointerestinal Tract in Rhesus Macaques"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Alcohol-Induced Organ Injury: Current and Future NIAAA Priorities"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mitochondria in Alcohol-Induced Organ Damage
7:30 pm - 7:50 pm
"Targeting of Mitochondrial Dynamics and Survival Mechanisms by Alcohol in Heart and Liver"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Role of the Circadian Clock in Alcohol-Induced Alterations in Hepatic Mitochondrial Energy Metabolism"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mitochondria-Targeted Cyp2E1 Modulates Alcohol Liver Toxicity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Beneficial and Harmful Level of Alcohol Interact with Mechanical Stretch Pattern on Mitochondrial Function in Vascular Smooth Muscle Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol-Induced Muscle Damage in C. elegans "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Preclinical/Translational Approaches and Treatment in Alcohol-Associated Diseases
9:00 am - 9:20 am
"Therapeutic Strategy in Severe Alcoholic Hepatitis: From Present to Future Development of New Molecules"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Therapeutic Targets for Alcoholic Hepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Performance of Liver Function Tests in the GenomALC Chohor for Alcohol Consumption: New Gender Cutoffs in Alcoholics with Liver Cirrhosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Cellular Biogenergetics: Personalizing Treatment in Alcoholic Liver Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Multitarget Approach for the Pharmacotherapy of Liver Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Role of SAMe in Liver Injury and Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Post-Metabolic Signaling and Stress Pathways
7:30 pm - 7:50 pm
"Deleterious Effects of Binge Drinking on Chronic Ethanol Feeding-Induced Metabolic Dysregulation and Cardiovascular Dysfunction in Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Alcohol and The Heart: Interference of Compensatory Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ethanol and Precision Medicine: New Considerations for an Old Problem"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"MicroRNA21 Inhibtion Restores Binge Drinking Impaired Microvascular Function in Young Adults"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol-Induced LPP3 Suppression Leads to Blood-Brain Barrier Dysfunction"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure