Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Molecular and Cellular Mechanisms of Fibrosis
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"The Complex Role of the ECM in Liver Fibrosis"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Circadian Rhythms and the Muscle Molecular Clock: Why Muscles Need to Keep Time"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein and Organelle Homeostasis: Novel Mechanisms of Alcohol-Induced Organ Injury
9:00 am - 9:20 am
"Regulation of Inflammatory Liver Injury by Autophagy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Role of SNARE Proteins in Dysregulated Autophagy in Alcoholic Pancreatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Ethanol-Based Perturbation of Lipid Droplet Catabolism in Hepatocytes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Pyroptosis in Alcoholic Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Mitochondrial Depolarization and Disregulated Mitophagy Occur in both Alcoholic and Non-Alcoholic Fatty Liver Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
" Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Hepatic Ceramide Reduction Alleviates Alcoholic Steatosis and Insulin Resistance in Female Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Impaired Autophagy Flux in Alcoholic Liver Disease: A Link Between miR155, Impaired Autophagosome Function and Exosome Production"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Small Molecule Inhibition of Gut Microbial Choline Metabolism as a Therapeutic Strategy in Alcoholic Liver Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Microbiota and Gut Barrier in Alcoholic Liver Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Alcohol Consumption Alters sIgA-Binding of Intestinal Microbes"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Gut Microbial Metabolite, Urolithin A Mitigates ALD by Enhancing Gut Barrier Integrity and Blocking Inflammation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Deletion of TRPV6 Channel Attenuates Alcohol and Stress-Induced Gut Barrier Dysfunction, Endotoxemia and Liver Damage"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Intestinal Stem Cell Proliferation and Differentiation in Alcoholic Liver Disease"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol and Cell-Cell Communications: From Extracellular Vesicles to Cyto-, Chemo- and Adipokines
9:00 am - 9:20 am
"Secretin Modulation of Biliary Senescence in Alcohol-Induced Liver Damage"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Extracellular Vesicle-Mediated Activation of Kupffer Cells in ALD"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"HMGB-1: DAMP Extroardinare"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Alcohol and Sweet Preference by the Hormone FGF21"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Kupffer Cells Undergo Anti-Inflammatory Changes in Response to Short-Term Alcohol Exposure"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Hepatocyte- and Myeloid-Derived Macrophage Migration Inhibitory Factor Contribute to Steatosis and ER Stress in Models of Ethanol Feeding in Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Intestinal miRNA Release by Phosphorylation of RNA-Binding Protein AUF1"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A New Mechanism of Liver Sinusoidal Endothelial Cell (LSEC) Dysfunction in Alcoholic Liver Disease: The Role of Cytochrome P450 E1 (CYP2E1) and HSP90 Acetylation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Big Data and Bioinformatics: Emerging Insights from Omics
7:30 pm - 7:50 pm
"Integrated 'Omics' Approach for Biomarker Discovery in Alcoholic Hepatitis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Application of Protein Arrays in Studying Severe Alcoholic Hepatitis and Beyond"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"miRNA Regulation of PBMCs in Alcoholic Hepatitis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Clinical Risk Factors for Alcoholic Cirrhosis in a Large Cohort of Heavy Drinkers"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Factors, Post-Metabolic Signaling and Stress Pathways
9:00 am - 9:20 am
"Acetaldehyde Dehydrogenase 2 Deficiency, Alcoholic LIver Disease and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lipins in Regulating Lipid Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Human Genetic Studies Reveal Heterogenous Causes of Fatty Liver Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Endocannabinoid-CB1-R Signaling Contributes to the Acute Cardiovascular Effects of Alcohol: Role of Gut-Liver-Heart Connection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The Epigenetic Regulator SIRT6 Protects the Liver from the Alcohol-Induced Tissue Injury via Control of Oxidative Stress"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Impact of Chronic Alcohol and Hepatocyte Circadian Clock Disruption on Diurnal Rhythms of Lipid Droplet-Associated Genes and Hepatic Steatosis in Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Hippo Kinase Mst1 Protects Alcoholic Induced Liver Damage by Inhibiting Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dysregulated Adult Splicing Program in Hepatocytes Leads to Severe Alcoholic Hepatitis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mitochondrial Dynamics, Dysfunction and Adaptation
7:30 pm - 7:50 pm
"Crosstalk of Microbiota and Host Mitochondria in Metabolic and Longevity Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mitochondrial Dysfunction in Skeletal Muscle"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mitochondrial Dynamics and Turnover in Liver Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Disruption of Mitochondrial Dynamics Accelerate Alcohol-Induced Liver Injury in Mouse by Regulating Mitophagy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol-Induced Mitochondrial Derangements in the Alveolar Macrophage"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Translational and Clinical Approaches for Treatment of Alcohol-Induced Tissue Injury
9:00 am - 9:20 am
"Controversies in Clinical Trials in ALD"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cardiovascular Risk Associated with Binge Drinking in Young Adults"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Interactions Between Alcohol Consumption and Metabolic Syndrome in the General Population"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Clinical Trials for Alcoholic Hepatitis: Anakinra"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Alcohol-Associated Alterations in Lung Immunity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Severity of Human Alcoholic Liver Disease Is Associated with Reduced NAD+ Content"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Immune Checkpoint Axes Are Dysregulated in Patients with Alcoholic Hepatitis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Systemic Effects of Alcohol: Cross-Talk Between Multiple Organs
7:30 pm - 7:50 pm
"Alcohol, Aging and HIV: Dissecting Mechanisms Driving Enhanced Comorbidities"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lung-Liver Interactions in Alcoholic Liver Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Adipocyte Apoptosis Enhances Hepatic Fat Accumulation and Liver Injury in the Experimental Models of Alcoholic and Nonalcoholic Steatohepatitis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Adipose FGFR1 Regulates Binge Alcohol-Induced Adipolipolysis and Hepatic Fat Accumulation in Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Stress Signaling: New Mechanisms of Alcohol-Evoked Cardiac Arrhythmias"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Chronic Alcohol-Induced Neuroinflammation Involves CCR2/5-Dependent Peripheral Macrophage Infiltration and Altered Synaptic Maturation"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure