Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Keynote Lectures
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"Th17 at the Intersection of Alcohol Use Disorder and Organ Damage"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Forward Genetics of Fatty Liver Disease"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Alcohol and the Metabolic Syndrome
9:00 am - 9:20 am
"Combined Liver Insult of Alcoholic and Non-Alcoholic Liver Disease: Lessons from a Preclinical Model"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Differences in the Role of RIP3 and MLKL in Alcohol-Associated and Non-Alcohol Associated Liver Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Metabolic Reprogramming and Liver Repair"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Altered Lipoprotein Metabolism in Alcoholic Hepatitis: Egg or Chicken?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"CYP2B10 is Induced by Binge Ethanol and Protects against Ethanol-Induced Liver Injury"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Clinical Relevance of Underlying Genetics in Patients with High Alcohol Use and Cirrhosis: the GenomALC Study"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Bioactive Lipid Metabolites: Novel Therapeutic Targets and Potential Treatment Strategies in Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ethanol-Induced Stress in Hepatocytes Attenuates Lipophagy of Nascent Lipid Droplets at the Endoplasmic Reticulum Surface"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Age-Related Dysregulation of the Bile Acid-Gut Microbiome Axis in Response to Ethanol"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Acceleration of Alcoholic Tissue Damage during Aging: Role of Autophagy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Exploring Microglia Autophagic Flux Impairments as a Driver of Advanced Age and Ethanol Induced Neuroinflammation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Vascular Effects of Binge Drinking in Mid-life Adults"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Age-Dependent Induction of the NADase CD38 is Implicated in the Progressive Alcohol-Associated Liver Disease during Aging"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Deletion of Phosphatidylethanolamine Methyltransferase Disrupts One-Carbon Metabolism to Promote Alcohol-Induced and Age-Dependent Progression of Liver Injury"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome and Intestine-Derived Molecules
9:00 am - 9:20 am
"Intestinal Targets of Probiotic-Derived Extracellular Vesicles in Alcohol-Associated Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Goblet Cells and Goblet Cell-Associated Passages as Modulators of Intestinal Immunity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Intestinal Exosomes in Alcohol-Induced Liver Injury"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Cell-Based Therapy for Alcohol-Associated Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The Role of Sphingosine Kinase 2 and Gut-liver-Axis in Alcohol-Induced live injury"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Increased Gut Leakiness, Endotoxemia, and Acute Liver Injury in ALDH2-KO Mice after a Single Dose of Binge Alcohol through the Gut-Liver Axis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Candida Albicans-Apecific Th17 Cell-Mediated Response Contributes to Alcohol- Associated Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Regulation of Intestinal IgA by Functional Hepatic pIgR is Required to Reduce Bacterial Overgrowth and Limit Ethanol-Induced Liver Disease in Mice."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunity and Infections: Implications for Diseases Associated with Alcohol
7:30 pm - 7:50 pm
"Alcohol, Lung Injury and COVID-19"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Alcohol-Related Lung Infection via Gut-Lung Axis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The 'Ins' and 'Outs' of Anaphylatoxins in Alcohol-Associated Liver Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mincle-GSDMD Mediated Release of IL-1ß/IL-18 Containing sEVs Contributes to Ethanol-Induced Liver Injury"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Platelets Upregulate S100A8, a Mediator of Endothelial Dysfunction and Inflammation, in Alcohol-Associated Hepatitis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol-Mediated Changes in Organ Metabolism
9:00 am - 9:20 am
"New Insight into Alcohol Metabolism, Organ Damage and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Protective Effects of FGF21 Against Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Skeletal Muscle in Alcohol-related Liver Disease- Organelle and Metabolic Responses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Alcohol and Clinical Effects on the Metabolic Syndrome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Combined Synthetic Cannabinoids and Alcohol Intoxication Induces Detrimental Cardiac Consequences: Role of CB1-R Signaling."
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Alcohol-Induced Oxidative Stress in Myocardium"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Role of Lymph from Alcohol-Treated Animals on Naïve Perilymphatic Adipose Tissue Immunomodulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Retinoid Stores Attenuate Deleterious Effects of Alcohol on Pancreas"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cancer Stem Cells and Alcohol-Associated Cancer
7:40 pm - 8:00 pm
"Alcohol and Colorectal Cancer: an Epidemiologic Perspective"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Alcohol and Colon Cancer: The “Clock” is Ticking"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Metabolic Reprogramming of Liver Tumor Initiating Cells"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Hepatocellular Carcinoma in NAFLD and ALD Occur via Distinct Stemness Activation And Metabolic Reprogramming in Diabetic Mice"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:35 pm
"Alcohol-Sensitized Macrophages Promote Colorectal Liver Metastasis"
9:35 pm - 9:40 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery of Mechanism-Based Biomarkers
9:00 am - 9:20 am
"The Degradome as Biomarkers and (Potentially) Mediators of Alcohol Organ Damage"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Extracellular Vesicle Signature Induced by Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Single Cell RNA Sequencing insights into the role of Kupffer cell subsets in progression of Alcohol-Associated Liver Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Non-Coding RNAs and Survival Outcomes in Patients with Alcohol-Associated Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Differential Expression of miRNA Cargo in Extracellular Vesicles Released from Adipocytes and Myotubes of Chronic Binge Alcohol-Administered SIV-infected Male Macaques"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Targeted Metabolomics of Gut Derived Microbial Metabolites in Alcohol-Associated Liver Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"ALPACA score: Development and Validation of a Score to Predict Risk of Liver-Related Events in Early Alcohol-Related Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Proteomic Analysis of Alcohol-Associated Hepatitis Reveals Glycoprotein NMB (GPNMB) as a Novel Hepatic Biomarker"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Concepts for Alcohol-Associated Organ Diseases
7:30 pm - 7:50 pm
"Alcohol-induced Cardiac Injury and Human iPSC for Cardiac Cell Therapy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Drug Targets for Treatment of Alcoholic Plus non-Alcoholic Steatohepatitis in Patients"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Folate Supplementation Protects Cardiac Outflow Tract Development from Synergistic Teratogenic Effects of Prenatal Alcohol Exposure and Notch Pathway Mutations"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"NLRP3-Dependent ASC Specks Released by Hepatocytes and Macrophages Perpetuate Inflammation in Alcoholic Hepatitis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Pericentral Gene Expression and Proliferation, Two Features Impaired in Human Alcoholic Cirrhosis, are Stimulated by SZN-043 in a Chronic-Binge Alcoholic Hepatitis Model"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Chronic Alcohol Blocks Efficacy of Anti-PD1 Immunotherapy in Mice and Humans"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure