Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Regulation and Genetics of the Renin-Angiotensin-Aldosterone System |
| Discussion Leader: Curt Sigmund (University of Iowa, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:30 pm | Armin Kurtz (University of Regensburg, Germany) "Regulation of Renin Expression
and Secretion in the Kidney, Modes and Mechanism" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Xavier Jeunemaitre (Paris Descartes University, France) "Molecular Genetics and Pathways Involved in Patients with Low Renin and Pseudo-Aldosteronism" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Renin Angiotensin Aldosterone Blockers: Are Dual Specificity Inhibitors the Next Great Thing? |
| Discussion Leaders: Rhian Touyz (University of Glasgow, United Kingdom) and Jan Danser (Erasmus MC, The Netherlands) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | John McMurray (University of Glasgow, United Kingdom) "Angiotensin Receptor Neprilysin Inhibition – The New Paradigm" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Lodi Roksnoer (Erasmus MC, The Netherlands) "Reno and Cardioprotective Effects of Dual AT1 Receptor-Neprilysin Inhibitors" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Oliver Domenig (Medical University of Vienna, Austria) "Comprehensive Biochemical Evaluation of the Renin-Angiotensin-System" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Fumitoshi Satoh (Tohoku University Graduate School of Medicine, Japan) "Novel Very Rapid Measurements of Active Renin and Aldosterone Concentrations and Its Clinical Significance for the Selection of Antihypertensive Agents" |
11:20 am - 11:25 am | Discussion |
| Young Investigator Presentations |
11:25 am - 11:30 am | Introduction by Discussion Leader |
11:30 am - 11:40 am | Douglas Bennion (University of Florida, USA) "Human Serum ACE2 Activity in Ischemic Stroke: A Moving Target for Translational Treatments" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Katrina Binger (Baker IDI Heart and Diabetes Institute, Australia) "Conditional Deletion of the (Pro)Renin Receptor Leads to Disturbed Pancreatic Beta-Cell Homeostasis and the Onset of Severe Diabetes" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Kristin Claflin (University of Iowa, USA) "Control of Resting Metabolic Rate by Angiotensin AT1A Receptors in Leptin-Sensitive Cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Johannes Kovarik (Medical University of Vienna, Austria) "Rise of Chymase Dependent Ang II Formation After Kidney Transplantation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Regulatory Networks and Clinical Relevance |
| Discussion Leader: Akira Nishiyama (Kagawa University Medical School, Japan) |
6:00 pm - 6:25 pm | Rhian Touyz (University of Glasgow, United Kingdom) "Chanzymes in Vascular Biology" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Youhua Liu (University of Pittsburgh School of Medicine, USA) "Wnt/β-Catenin Signaling and Renin Angiotensin System" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Maira Soto (University of Southern California, USA) "Modifying the Renin-Angiotensin System to Improve Pulmonary Health in Type 2 Diabetes" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Adam Mullick (Ionis Pharmaceuticals, USA) "LICA-Antisense Oligonucleotide Inhibition of Angiotensinogen: A New Therapeutic Approach for Treatment-Resistant Hypertension" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | New Roles for Renin, Renin Receptor and ACE in the Kidney |
| Discussion Leaders: Thomas Coffman (Duke-NUS Medical School, Singapore) and Rodrigo Fraga-Silva (Wyss Center for Bio and Neuroengineering, Switzerland) |
9:00 am - 9:25 am | Maria Louisa Sequiera-Lopez (University of Virginia, USA) "Renin Cell Progenitors in Development and Disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jorge Giani (Cedars-Sinai Medical Center, USA) "Renal Tubular Epithelial ACE Is Obligatory for Experimental Hypertension" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Johannes Stegbauer (Heinrich Heine University Düsseldorf, Germany) "Ciliary Neurotrophic Factor Deficiency Protects Against Angiotensin II-Dependent Hypertension and Hypertensive End Organ Damage" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Minolfa Prieto-Carrasquero (Tulane University, USA) "Consequences of the Functional Role in the Prorenin Receptor in the Collecting Duct" |
11:15 am - 11:25 am | Discussion |
| Selected Presentations from the GRS |
11:25 am - 11:30 am | Introduction by Discussion Leader |
11:30 am - 11:45 am | Dane Jensen (University of Nevada, Reno, USA) "Epigenetic Regulation of Brain (Pro)Renin Receptor by Epithelial Sodium Channel in DOCA-Salt Hypertension" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Nicole Littlejohn (University of Iowa, USA) "Suppression of Resting Metabolic Rate by the Angiotensin AT2 Receptor" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Antonio Peluso (University of Southern Denmark, Denmark) "AT2-Receptor Stimulation Promotes NO Release Through eNOS Serine1177 Phosphorylation and eNOS Tyrosine657 Dephosphorylation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Immunity, Inflammation and AT1 Receptors |
| Discussion Leader: Ulrich Wenzel (University Medical Center Hamburg-Eppendorf, Germany) |
6:00 pm - 6:25 pm | Steven Crowley (Duke University Medical Center, USA) "A Role for Inflammatory Cytokines in the Pathogenesis of Hypertension" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Daniela Carnevale (Neuromed Insitute for Neurosciences, Sapienza University of Rome, Italy) "Neuroimmune Interactions in Hypertension" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Hamiyet Unal (Erciyes University, Turkey) "Novel Function of RGS2 as a Transcriptional Repressor of STAT3 in Regulating Gene Expression Involved in AngII-Induced Pathogenesis" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Duska Dragun (Charité - Universitätsmedizin Berlin, Germany) "Structural and Functional Consequences of Antibody Mediated AT1R Activation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Brain RAS |
| Discussion Leaders: Eric Lazartigues (LSU Health Sciences Center New Orleans, USA) and Dominik Muller (Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, Germany) |
9:00 am - 9:25 am | Yumei Feng (University of Nevada, USA) "Neuronal (Pro)Renin Receptor in High-Fat Diet Induced Diabetes and Obesity" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Javier Stern (Georgia Regents University, USA) "Novel Insights into Central Mechanistic Targets Mediating AngII Actions in the Brain" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Keisuke Shinohara (University of Iowa, USA) "Selective Deletion of Intracellular Renin in the Brain Causes Hypertension and Elevated Sympathetic Nervous System Activity" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
| Salt and Metabolism |
10:55 am - 11:20 am | Jens Titze (Vanderbilt University, USA) "Salt Metabolism: From Volume Control to Biological Barrier Formation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jonathan Jantsch (University of Regensburg, Germany) "Salt Storage Creates Biological Barrier to Ward Off Infection" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Frederique Yannikouris (University of Kentucky, USA) "Adipocyte PRR, a New Target to Prevent Obesity-Hypertension?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Technical
Advances in Optogenetics/Chemogenetics and Applications to Ang-II and Its Neural Circuits |
| Discussion Leader: Mingyu Liang (Medical College of Wisconsin, USA) |
6:00 pm - 6:25 pm | Sergey Kasparov (University of Bristol, United Kingdom) "An Overview of Current Optogenetic Actuators and Reporters" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Eric Krause (Univerisity of Florida, USA) "Optogenetic Dissection of 'Angiotensin Sensitive' Brain Circuits: Implications for Mental and Cardiovascular Health" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Colin Sumners (University of Florida, USA) "Hindbrain Angiotensin Type 2 Receptors and Hypertension" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Kamal Rahmouni (University of Iowa, USA) "Opto- and Chemo-Genetic Mediated Modulation of POMC and AGRP Neurons" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Recent Advances in the RAS |
| Discussion Leaders: Toshiro Fujita (The University of Tokyo, Japan) and Lisa Cassis (University of Kentucky, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Mark Chappell (Wake Forest University, USA) "An Intracellular Angiotensin-(1-7) System" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Katie Hood (University of Glasgow, United Kingdom) "The Ang-(1-7)-ET-1 Axis – A New Partnership" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Shigeru Shibata (University of Tokyo / Teikyo University, Japan) "Uncovering Pathways Downstream of Angiotensin II Signaling in the Distal Nephron of the Kidney" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Sadashiva Karnik (Cleveland Clinic, USA) "Molecular Recognition and Functional Selectivity Mechanisms of Angiotensin II Type 1 Receptor Blocking Drugs" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Kenneth Gross (Roswell Park Cancer Institute, USA) "Renin-Expressing Cell Lineage and Progenitor Cell Function During Pancreatic Neuroendocrine Differentiation and Development" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Genome and Editing and MicroRNAs |
| Discussion Leader: Michael Bader (Max Delbrück Center for Molecular Medicine, Germany) |
6:00 pm - 6:25 pm | Michael Bader (Max Delbrück Center for Molecular Medicine, Germany) "Novel Transgenic Technologies for the Functional Analysis of the RAS" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Mingyu Liang (Medical College of Wisconsin, USA) "MicroRNAs in Hypertension: From Cells to Human Subjects" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Yu Wang (University of Newcastle, Australia) "Role of hsa-miR-181a in Regulating Human Placental Renin Expression and Prorenin Protein" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Andrew Baker (University of Edinburgh, United Kingdom) "miRNA Regulation and Function During Vascular Remodelling" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |