Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Paradigm Shifts in the RAAS
Keynote lectures by Dr. Ariel Gomez and Dr. David Harrison.
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Control of Renin Cell Identity in Homeostasis and Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Insights into the Role of RAS and Other Hypertensive Stimuli in Immune Activation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Additional RAS Signaling Mechanisms / Novel Functions of Renin Cells
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"20-HETE-RAS Interactions in Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Cardiovascular Ageing Regulated by Heterodimerization of Angiotensin AT1 Receptor with Purinergic P2Y6 Receptor"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:40 am
Introduction by Discussion Leader
10:40 am - 11:05 am
"The Juxtaglomerular Apparatus: A Renin Lineage Precursor Cell Niche for Glomerular Regeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"The Origin, Fate, and Significance of Renin Progenitors During Hematopoiesis"
11:40 am - 11:50 am
Discussion
11:50 am - 11:55 am
Introduction by Discussion Leader
11:55 am - 12:10 pm
"Loss of Urine Concentration and Subsequent Dehydration Characterizes Hypertension in Rats with Chronic Renal Failure"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondrial Fission Mediates Hypertensive Vascular Remodeling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cross-Talk with Angiotensin Receptors
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Soluble (Pro)renin Receptor: Its Generation and Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"(Pro)renin and Wnt/Beta-Catenin Signaling in Chronic Kidney Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
"Cleavage of the Soluble Prorenin Receptor and the Implications for Preeclamptic Pregnancies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Big Angiotensin-25: A Novel Component of the Renin Angiotensin System"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Neural Control Mechanisms: Does the Brain Dominate the Circulation?
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Shedding Light on the Role of 'Angiotensin-Sensitive' Neural Circuits in the Coordination of Neuroendocrine and Autonomic Control"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Brain RAS, Inflammation and Blood Brain Barrier Integrity: Opposite Effects of Hypertension and Exercise Training"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:45 am
Introduction by Discussion Leader
10:45 am - 11:10 am
"Role of the Brain Angiotensin System in Chronic Intermittent Hypoxia Induced Hypertension"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Microglial Activation Regulate Blood Pressure in Ang II Hypertension"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Leptin Modulates the RAS Within the Arcuate Nucleus to Stimulate Resting Metabolic Rate"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Melanocortin 3 Receptor Deletion Induces Skin-Specific Na and Water Loss that Cannot Be Compensated by Glucocorticoid-Driven Urea Osmolyte Generation and Accumulation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bench Comes to the Real World: MR and Its Antagonist
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Repositioning Mineralocorticoid Receptor Antagonists: Pathophysiological and Clinical Insights"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Putting the 'A' Back into RAAS: Mineralocorticoid Signalling in Cardiovascular Disease"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 8:55 pm
"Mineralocorticoid Receptro in Renal Intercalated Cells Mediates Pendrin Regulation by Renin-Angiotensin-Aldosterone System to Maintain Fluid Homeostasis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Angiotensin II Type 2 Receptor Stimulation Decreases Sensory Neuropathy Induced by Vincristine in Mice"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mitochondrial Fission Is Regulated by Canonical NF-kB Signaling and Is Required for Vascular Inflammation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gut Microbiome, Immunity, Salt-Sensitive Hypertension and the RAAS
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Brain-Gut Interactions and RAS in Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Hypertension and Gut Microbiota: Links and Treatment"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Angiotensin-Converting Enzymes Enhances the Oxidative Response and Bactericidal Activity of Neutrophils"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:15 am
Introduction by Discussion Leader
11:15 am - 11:40 am
"Vascular Rho Kinase and RAS in Ageing-Associated Salt-Sensitive Hypertension"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Smooth Muscle PPARgamma Mutation Causes Salt-Sensitive Hypertension"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"The ACE N-Domain Plays an Active Role in Renal Inflammation and Sodium Retention During Diabetes Independently from Angiotensin II Generation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Approaches Open New Windows into RAS Function
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Smooth Muscle RhoBTB1 Is a Novel Regulator of Vascular Function, Arterial Stiffness and Blood Pressure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Central-Acting Aminopeptidase A Inhibitors for New Treatment of Hypertension and Heart Failure: From Discovery to Clinical Trial"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
"Treating Stroke via the Nose to Brain Highway: Intranasal Delivery of Angiotensin Type 2 Receptor Agonist After Ischemic Stroke Is Neuroprotective"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"First-in-Man Clinical Evaluation of an Angiotensin AT2-Receptor Agonist in a Phase I, Randomised, Double-Blind Clinical Trial Revealed Safety, Tolerability and a Beneficial Effect on Lipoprotein Pattern"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Angiotensin: Possible Key for Immune Response
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"A Vascular Coagulation-Inflammatory Circuit in Arterial Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Targeting Novel Immune Signaling in Hypertension"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:50 am
Introduction by Discussion Leader
10:50 am - 11:15 am
"Role of AngII in Neuroinflammation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Activation of Natural Killer Cells in Recombination Activating Gene 1 Null Mice with Angiotensin II Induced Hypertension"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Role of AT1 Receptor-Mediated ADAM17 Signaling in Glutamatergic Neurons in Neurogenic Hypertension"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"NI956: A Potent Orally Active Aminopeptidase A Inhibitor with Central Antihypertensive Effects in DOCA-Salt Rats"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Immunosuppression in Type 2 Diabetes Is Improved with A(1-7) Treatment in a S. aureus Infection Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex, Aging and Death in the RAAS
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Sudden Death in Muscular Dystrophy: Role of the Renin-Angiotensin System"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Sex Differences and Aging in the RAS"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
"Chronic Treatment of Short Chain Fatty Acids Attenuates the Development of Atherosclerosis in Angiotensin II Infused Apolipoprotein E Deficient Mice"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Loss of Interleukin 21 Protects Against Hypertension and Hypertension Associated Inflammation and End-Organ Damage"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure