Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Understanding Complexity to Maintain Cardiovascular Health
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Networking Through Angiotensin: From Molecules to Systems"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Mechanisms that Increase Peripheral Vascular Resistance Beyond the AT1 Receptor"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Therapeutics Targeting the RAAS: Benefits and Risks
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Fasting Affects Your Microbiome and Immune Cells with Long-Term Benefit for Your Blood Pressure"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Oral Therapy for Diabetic Retinopathy by Genetically Engineered Probiotics Expressing Ang-(1-7)/ACE2"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Impact of Statins on Aldosterone Biosynthesis: Potential Relevance to Cardiovascular Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:05 am
Introduction by Discussion Leader
11:05 am - 11:15 am
"Inhibiting ACE C-Domain and Neprilysin: A Potential New Therapy in Hypertension"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"New Ligands and News About Old Ligands for the Angiotensin AT2-Receptor"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"RNAi Therapeutics Targeting Angiotensinogen"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Angiotensinogen Directed siRNA: Efficacy in Hypertension and Chronic Kidney Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Plasticity, Repair and Rhythm in the RAAS
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Kidney Repair: Mechanisms and Trade-off"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Active Time-Restricted Feeding Potently Protects Blood Pressure Circadian Rhythm in Diabetic Mice"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:10 pm
Introduction by Discussion Leader
7:10 pm - 7:20 pm
"Epigenetic Remodeling, Not Proliferation, Mediates Renin Cell Plasticity"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
"Automatic Analysis of Patterns of Differentiation of Renin-Lineage Cells During Nephrogenesis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Interaction Between the Angiotensin-(1-7) Mas Receptor and the Alamandine Mas-Related G Protein-Coupled Receptor Member D Receptor"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Functions of the RAAS and Its Receptors
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Olfactory Receptor 78, Short Chain Fatty Acids and Blood Pressure Regulation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"IRAP/AT4 Receptor: A New Target for the Treatment of Cardiovascular Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Systemic and Kidney Effects of Novel Forms of ACE2"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:05 am
Introduction by Discussion Leader
11:05 am - 11:25 am
"Sex Differences in T Cell-Dependent Ang II Hypertension"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Endothelial Mineralocorticoid Receptor Mediates Aldosterone and High Salt-Induced Abdominal Aortic Aneurysm in Mice"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Relationship Between Renin-Angiotensin-Aldosterone System and Renal Kir5.1 Channel"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Megalin: A Novel Endocytic Receptor for Prorenin and Renin?"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RAAS, Higher Brain and Neuroimmune Functions
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Angiotensin II and Fear Memory: Implications for Post-Traumatic Stress Disorder (PTSD) and Co-Morbid Cardiovascular Disease"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Role of RAAS Modulation in Neurocognitive Therapeutics"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"New Molecular Mechanisms of Neural Regulation of Immunity in Hypertension"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Resilience of Cerebral Arterioles to Vasoconstriction Protects the Brain from Vascular Dementia and Stroke"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Single Cells, Epigenetics and Genome Engineering
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Therapeutic Potential of Mas Activation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"ACE and Mitochondrial Function"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Angiotensin II Induced Renal Injury"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Aging Alters the Epigenetic Asymmetry of Stem Cell Division"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader
10:55 am - 11:15 am
"Hypertension and Inflammation: Unexpected Communication Between Innate Immunity and Juxtaglomerular Cells"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Genome Engineering and High Throughput Screening Combinatorial Drug Targets"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Fate of Renin Cell Progenitors in the Developing Kidney Vasculature"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Global Deletion of MicroRNA-181a Results in Elevated Blood Pressure and Salt Sensitivity in Mice via Up-Regulation of Renin"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Imaging of Vascular Inflammation During the Formation of Abdominal Aortic Aneurysms by Noninvasive 1H/19F Magnetic Resonance Imaging"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"The Application of Biophotonics in the Zebrafish to Explore the Biology of Renin Cells"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:10 pm
Introduction by Discussion Leader
7:10 pm - 7:25 pm
"Intravital Imaging of Macula Densa-Mediated Renal Vascular and Glomerular Remodeling"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Advancements in Imaging Renin Release and Cell Biology in Juxtaglomerular Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Precision Medicine, Big Data and the RAAS
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Applying Omics-Based Approaches for the Diagnosis of Endocrine Hypertension"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Enhancing Interactions Between MasR and ETBR as a New Vasoprotective Strategy"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Role of Human T Cells in Resistant Hypertension"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening and Hypertension"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader
10:55 am - 11:15 am
"An Integrated Forward Genetic Screen to Identify Genes Influencing Blood Pressure and Hypertension"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Blood Pressure Management in Young Adults"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
Introduction by Discussion Leader
12:00 pm - 12:10 pm
"Brain Renin-Angiotensin System Blockade with Firibastat, an Orally Active, Central Acting Aminopeptidase A Inhibitor Prodrug Prevents Cardiac Dysfunction After Myocardial Infarction in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cardioprotective Effect of Diminazene Aceturate in Ischemic Reperfusion-Induced Cardiac Injury"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: From Molecular Mechanisms to Public Health Impact
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
"Angiotensin II and Reactive Oxygen Species: A Complex Journey to Endothelial Permeability"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:35 pm
"Translating Discovery Science into Cardiovascular Health"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure