| SATURDAY |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Session |
| Discussion Leader: Sean Thatcher (University of Kentucky) |
| 3:15 pm - 3:45 pm | Dominik Mueller (Max-Delbruck-Centrum, Berlin, Germany)
"Unpredictable Results - The Big Chance in Science" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | The RAS and Diabetes |
| Discussion Leaders: Rajesh Kumar and Candice Thomas (Texas A&M Health Science Center, Temple, TX) |
| 5:30 pm - 5:50 pm | Candice Thomas (Texas A&M Health Science Center)
"The Cardiac Renin Angiotensin System in Diabetes" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Katrina Binger (Max-Delbrueck Center for Molecular Medicine, Berlin, Germany)
"(Pro)renin Receptor Conditional Knockout Causes Beta-Cell Loss and Hyperglycemia by Inducing Pathological Autophagy"
|
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Robin Shoemaker (Graduate Center for Nutritional Sciences, University of Kentucky)
"ACE2 Deficiency Augments the Development of Type 2 Diabetes in Obese Mice"
|
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Juliana Colucci (Universidade Federal de São Paulo, Sao Paulo, Brazil)
"Difference Between ACE/ACE2 Balance in Diabetic Mice Harboring One or Three Copies of Angiotensin Converting Enzyme Gene" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | New Therapeutics for the RAS: Targeting the ACE2/Ang-(1-7)/MasR and AT2 Receptor Pathways |
| Discussion Leaders: Kathryn Sandberg (Georgetown University, Washington DC) and Jan Danser (Erasmus MC, Rotterdam, Netherlands) |
| 9:00 am - 9:20 am | Rodrigo Fraga-Silva (Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland)
"ACE2 Activators for Cardiovascular Diseases"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Robert Regenhardt (University of Florida, Gainesville, FL)
"Transcriptomic Modeling of the Cerebroprotective Effects of AT2R Agonist Compound 21 in Ischemic Stroke" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Emma Jones (Monash University, Melbourne, Australia)
"Pharmacology of Novel AT2 Receptor Agonists"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Gerry Wagenaar (Leiden University Medical Center, Leiden, Netherlands)
"Intervening in AT2 Signalling Attenuates Hyperoxia-Induced Lung and Heart Injury in Newborn Rats"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | New Developments and Signaling in the RAS |
| Discussion Leaders: Alan Daugherty (University of Kentucky, Lexington, KY) and Johannes Stegbauer (UKD, Dusseldorf, Germany) |
| 1:30 pm - 1:50 pm | Eva Königshausen (UKD, Dusseldorf, Germany)
"Ang II Promotes Beta-Arrestin 2 Mediated Endocytosis in Podocytes"
|
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Qian Chen Yong (Texas A&M Health Science Center, Temple, TX)
"Hydrogen Sulfide Inhibits the Activation of the Renin-Angiotensin System in Diabetic Heart" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
