Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Computational Vaccine Design
Discussion Leader: Jean-Philippe Burckert (BISC Global, USA)
3:15 pm - 3:50 pm
Jacob Glanville (Distributed Bio, Inc., USA)
"Computational Epitope Focusing Enables Universal Vaccine Design, or How I Became a Guatemalan Pig Farmer"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Immunomodulatory Antibodies for Cancer, Autoimmunity, and Disease
Discussion Leader: Eric Escobar-Cabrera (Zymeworks Inc, Canada)
5:30 pm - 5:50 pm
Eleonora Trotta (University of California, San Francisco, USA)
"Discovery of Novel Human Anti-IL-2 Antibodies that Potentiate Regulatory T Cells by a Structure-Based Mechanism"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Maria Bottermann (MRC Laboratory of Molecular Biology, United Kingdom)
"Sequential Post-Entry Neutralization of Human Adenovirus Is Mediated by Complement and TRIM21"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Alicia Chenoweth (Burnet Institute, Australia)
"Unique Proinflammatory Properties of IgG4 in the Activation of Human Inflammatory Cells: Implications for Therapeutic Monoclonal Antibodies"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Stuart Ainsworth (Liverpool School of Tropical Medicine, United Kingdom)
"Next Generation Antivenoms"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Next-Generation Antibodies via In Silico and In Vitro Engineering
Discussion Leader: Erik de Graaf (Sanquin Research, The Netherlands)
9:00 am - 9:20 am
Cristina Parola (ETH Zurich, Switzerland)
"Developing a Plug-and-(Dis)play Hybridoma Platform for Protein Expression and Engineering"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Mario Sanches (Zymeworks, Inc., Canada)
"AlbuCOREā¢: A Novel Antibody-Alternative Molecular Platform Based on Human Serum Albumin"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Emma Sutton (University of Southampton, United Kingdom)
"Binding Geometry of Anti-Human CD32b Antibodies Influences Receptor Localization and Biological Activity"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Johannes Loeffler (University of Innsbruck, Austria)
" Describing the CDR-H3 Loop as a Conformational Ensemble"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building a Successful Academic Lab or Biotech Start-Up
Discussion Leader: Jeanette Leusen (University Medical Center Utrecht, The Netherlands)
1:30 pm - 2:30 pm
Panel Discussion
Building a Successful Academic Lab or Biotech Start-Up
James Ernst (Genentech, USA)
Jacob Glanville (Distributed Bio, Inc., USA)
P. Mark Hogarth (Burnet Institute, Australia)
Sai Reddy (ETH Zurich, Switzerland)
Sally Ward (Texas A&M Health Science Center, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes