Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: Brain Barriers in Regulation of CNS Immune Privilege
The keynotes will address novel insights on the role of brain barriers in regulating afferent and efferent connections of the immune system with the CNS.
Discussion Leaders: Aaron Johnson (Mayo Clinic, USA) and Britta Engelhardt (University of Bern, Switzerland)
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7:40 pm - 8:15 pm |
Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
"Translational Insights into Meningeal Lymphatic Vessels"
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8:15 pm - 8:30 pm |
Discussion
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8:30 pm - 9:05 pm |
Alexander Flügel (Institute for Multiple Sclerosis Research and Neuroimmunology, University Medical Center Göttingen, Germany)
"How Autoaggressive Effector T Cells Overcome the Blood Brain Barrier"
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9:05 pm - 9:20 pm |
Discussion
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9:20 pm - 9:30 pm |
General Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
The Role of Brain Barriers in CNS Fluid Flow: Imaging, Modeling and Neurosurgery
Discussion Leaders: Elizabeth De Lange (Leiden University, The Netherlands) and Stina Syvänen (Uppsala University, Sweden)
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9:00 am - 9:20 am |
Stephen Hladky (University of Cambridge, United Kingdom)
"Fluxes and Flows: The Need to Consider Them Together"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Mark Wagshul (Albert Einstein College of Medicine, USA)
"Magnetic Resonance Elastography: Interrogation of Biological Tissue Stiffness as a Noninvasive Biomarker of Pathology"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:20 am |
Jeffrey Iliff (Oregon Health and Science University, USA)
"Evidence for Perivascular Astroglial Dysfunction in the Development of Human Alzheimer’s Disease"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:20 am |
Vartan Kurtcuoglu (University of Zurich, Switzerland)
"Computational Modeling of CNS Fluid Flow: Differentiating Fluid Flow and Solute Transport in the CNS"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:50 am |
Peter Vajkoczy (Neurochirurgische Klinik / Charite - Universitätsmedizin Berlin, Germany)
"Mechanisms and Consequences of BBB Disruption in Neurosurgical Diseases"
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11:50 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Steven Proulx (ETH Zurich, Switzerland)
"Rapid Outflow of Cerebrospinal Fluid Through Lymphatic Vessels During Waking Conditions Limits Tracer Spread to Paravascular Spaces of the Brain"
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12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:30 pm |
General Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Irena Loryan (Uppsala University, Sweden) and Brandon Kim (University of Wisconsin-Madison, USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Brain Barriers in Development and Homeostasis
Discussion Leaders: Daniela Virgintino (University of Bari, Italy) and Jessica Plavicki (Brown University, USA)
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7:30 pm - 7:50 pm |
Benoit Vanhollebeke (Université Libre de Bruxelles, Belgium)
"Molecular Basis of the Single-Cell Control Mechanism of Brain Angiogenesis and BBB Formation in Zebrafish"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Maria Lehtinen (Boston Children's Hospital, USA)
"Zooming in on the Choroid Plexus"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Kjeld Møllgård (University of Copenhagen, Denmark)
"Establishment of Brain Barriers and Functional Interfaces During Human Development"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Eric Klein (Brown University, USA)
"Optogenetic Control of Cerebral Microvessel Tone and Blood-Brain Barrier Permeability"
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9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:30 pm |
General Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Brain Barrier Bioinformatics and Omics
This session will include introduction of a BBB expression atlas (BBBHub) making quality controlled brain barriers OMICS data available to the barriers scientific community.
Discussion Leaders: Tetsuya Terasaki (Tohoku University, Japan) and Stefan Liebner (University of Frankfurt, Germany)
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9:00 am - 9:20 am |
Christer Betsholtz (Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Sweden)
"Defining Vascular Cell Types, Subtypes and Phenotypes in the Brain Using Single Cell RNA Sequencing"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Gijs Kooij (VU University Medical Center, The Netherlands)
"Transcriptomic of the Choroid Plexus in Multiple Sclerosis"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:20 am |
Ioannis Karamanos (University of Artois, France)
"Characterisation of the Proteome of the Brain-Like Endothelial Cells (BLECs) in a Human BBB Model"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Group Photo / Coffee Break
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11:00 am - 11:20 am |
Danica Stanimirovic (National Research Council / University of Ottawa, Canada)
"Building the BBB CARTA: Where Molecules Meet Function"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:40 am |
Selected from Poster Abstracts: Kazuki Sato (Tohoku University, Japan)
"In Vivo Screening of Peripheral Tissues-Derived Blood-Brain Barrier Permeable Endogenous Proteins by Quantitative Comprehensive SWATH Proteomics"
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11:40 am - 11:45 am |
Discussion
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11:45 am - 12:05 pm |
Remy Bruggman (University of Bern, Switzerland)
"BBBHub: Blood-Brain Barriers Expression Atlas"
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12:05 pm - 12:15 pm |
Discussion
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12:15 pm - 12:30 pm |
General Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Molecular Mechanisms Regulating Barrier Integrity
Session in honor of Morris J. Karnovsky.
Discussion Leaders: Chenghua Gu (Harvard Medical School, USA) and Francesca Bosetti (National Institute of Neurological Disorders and Stroke, NIH, USA)
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7:30 pm - 7:50 pm |
Matthew Campbell (Smurfit Institute of Genetics, Trinity College Dublin, Ireland)
"Dose Dependent Expression of Claudin-5 Is a Modifying Factor in Neurological Disease"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Elisabetta Dejana (IFOM - The FIRC Institute of Molecular Oncology, Italy)
"Transcriptional Regulation of the Blood Brain Barrier Differentiation"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Dritan Agalliu (Columbia University Medical Center, USA)
"Wnt/Beta-Catenin Signaling as a Therapeutic Target for Blood-Brain Barrier Repair in Neurological Disorders"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Caroline Menard (Université Laval, Canada)
"Social Stress Induces Neurovascular Pathology Promoting Depression"
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9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:30 pm |
General Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Role of the Brain Barriers in Tumor Growth and Brain Metastases
Discussion Leaders: Patricia Steeg (National Cancer Institute, NIH, USA) and William Elmquist (University of Minnesota, USA)
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9:00 am - 9:20 am |
Paul Lockman (West Virginia University, USA)
"Getting Across the Blood-Brain and Blood-Tumor Barrier: Bench to Bedside Translation of Novel Chemotherapeutics"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Timothy Heffron (Genentech, Inc., USA)
"Considerations in the Design and Use of Small Molecule Drugs for Brain Cancer"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:20 am |
Frank Winkler (German Cancer Research Center, Germany)
"Novel Insights into Blood-Brain Barrier Function and the Perivascular Niche in Brain Tumors: From Biology to Therapy"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:20 am |
Nathalie Agar (Harvard Medical School / Dana-Farber Cancer Institute / Brigham and Women's Hospital, USA)
"Spatial Distribution of Tumor – Surgical Molecular Imaging"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:50 am |
Jann Sarkaria (Mayo Clinic, USA)
"Impact of Heterogeneous Drug Delivery on Treatment Efficacy in Glioma"
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11:50 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Sadhana Jackson (National Institutes of Health, USA)
"The Effect of an Adenosine A2A Agonist on Intra-Tumoral Concentrations of Temozolomide in Patients with Recurrent Glioblastoma"
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12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
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7:30 pm - 9:30 pm |
Novel Concepts in Drug Delivery Across the Brain Barriers
Discussion Leaders: Margareta Hammarlund-Udenaes (Uppsala University, Sweden) and Joseph Nicolazzo (Monash University, Australia)
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7:30 pm - 7:50 pm |
Robert Thorne (University of Wisconsin-Madison, USA)
"Mechanisms Underlying the Central Delivery and Distribution of Macromolecules and Other Large Biologics: Focus on Perivascular Space Access and Transport as Key Regulators of Efficiency"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Erin Lavik (University of Maryland, Baltimore County, USA)
"Engineering Nanoparticles to Treat CNS Injury"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Harm-Anton Klok (Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland)
"Cell Mediated Drug Delivery Across the BBB"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Krzysztof Kucharz (University of Copenhagen, Denmark)
"Two-Photon Fluorescence Imaging: A Platform to Investigate Cell-Penetrating Peptides and Liposome-Based Nanocarriers for Drug Delivery Across the BBB"
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9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:30 pm |
General Discussion
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Thursday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
BBB Microenvironment in Health and Disease
Discussion Leaders: Reina Bendayan (University of Toronto, Canada) and Anika Hartz (University of Kentucky, USA)
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9:00 am - 9:20 am |
Martha O'Donnell (University of California, Davis, USA)
"The Blood Brain Barrier in Diabetes: Alterations in Ion Transporters, Channels and Intracellular [Ca]"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Eduardo Candelario-Jalil (University of Florida, USA)
"Neurovascular Protection by Adropin in Ischemic Stroke"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:10 am |
Selected from Poster Abstracts: Laura Bojarskaite (GliaLab, Letten Center, Institute of Basic Medical Sciences, University of Oslo, Norway)
"Astrocyte Ca2+ Signaling at the Blood-Brain Barrier Across Sleep-Wake States"
|
10:10 am - 10:15 am |
Discussion
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10:15 am - 10:25 am |
Selected from Poster Abstracts: Pia Christensen (Lundbeck / Center for Translational Neuromedicine, University of Copenhagen, Denmark)
"The Importance of the Glymphatic System in the Migration of Therapeutic Monoclonal Antibodies"
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:20 am |
Joanna Szmydynger-Chodobska (Alpert Medical School, Brown University, USA)
"Involvement of Pial Vessels in Leukocyte Invasion into the CNS"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:40 am |
Selected from Poster Abstracts: Kelly Doran (University of Colorado School of Medicine, USA)
"The Contribution of the Cell Surface Adhesin BspC to Group B Streptococcal BBB Penetration and the Development of Meningitis"
|
11:40 am - 11:45 am |
Discussion
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11:45 am - 11:55 am |
Selected from Poster Abstracts: Christy Wilson (Stanford University, USA)
"In Vivo Imaging of Targeted Exosomes in a Metastatic Brain Tumor Model"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Irena Loryan (Uppsala University, Sweden)
"Recent Breakthroughs in Brain Barriers Research"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Keynote Session: Engineering the Human Brain Barriers
The trendsetting theme of bioengineering the human brain barriers will be addressed by a junior and senior closing keynote.
Discussion Leaders: Maria Deli (Biological Research Centre, Hungarian Academy of Sciences, Hungary) and Adam Chodobski (Alpert Medical School, Brown University, USA)
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7:30 pm - 8:05 pm |
Tae-Eun Park (Ulsan National Institute of Technology, South Korea)
"Human BBB-on-a-Chip for Drug Testing and the Identification of the BBB Shuttle Peptide"
|
8:05 pm - 8:15 pm |
Discussion
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8:15 pm - 8:50 pm |
Eric Shusta (University of Wisconsin-Madison, USA)
"Stem Cell Modeling of the Neurovascular Unit"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:15 pm |
General Discussion
|
9:15 pm - 9:30 pm |
Closing Remarks
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|