1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Blood-Brain Barrier Impairments in Huntington’s Disease
Natasha O'Brown (Harvard Medical School, United States)
3:45 pm - 4:15 pm
Francesca Cicchetti (Centre de Recherche du CHU de Québec, Université Laval, Canada) "Blood-Brain Barrier Impairments in Huntington’s Disease: How Do They Contribute to Disease Pathology and Can They be Targeted to Develop New Treatments?"
4:15 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
New Discoveries in CNS Barrier Physiology and CNS Drug Delivery
Laura Bojarskaite (GliaLab, Letten Center, University of Oslo, Oslo University Hospital, Norway) and Benjamin Gastfriend (University of Wisconsin-Madison, United States)
7:30 pm - 7:50 pm
Tasneem Arsiwala (West Virginia University, United States) "Focused Ultrasound Increases Drug Permeability and Drug Efficacy Across the Blood-Brain Barrier and Blood-Tumor Barrier in a Preclinical Model of Brain Metastasis of Breast Cancer"
7:50 pm - 8:00 pm
8:00 pm - 8:20 pm
Steffi Schumacher (Ghent University, Belgium) "Targeting Astrocytic Connexins to Prevent Radiation-Induced BBB Leakage"
8:20 pm - 8:30 pm
8:30 pm - 8:50 pm
Leon Smyth (Washington University in St. Louis, United States) "Cerebrospinal Fluid Regulates Skull Bone Marrow Niches via Direct Access Through Dural Channels"
8:50 pm - 9:00 pm
9:00 pm - 9:20 pm
Irene Spera (Theodor Kocher Institute, Switzerland) "Cerebrospinal Fluid Outflow Pathways at the Cribriform Plate Along the Olfactory Nerves"
9:20 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Physiological and Functional Changes in CNS Barriers with Age and Disease
Raleigh M Linville (Massachusetts Institute of Technology, United States) and Diana Bohannon (EVMS, United States)
9:00 am - 9:20 am
Julia Derk (CU Denver - Anschutz Medical Campus, United States) "Making and Breaking Meninges Barriers: Arachnoid Barrier in Development and Disease"
9:20 am - 9:30 am
9:30 am - 9:50 am
Francisco Garcia (MIT Department of Brain and Cognitive Sciences, United States) "Single-Cell Dissection of the Human Brain Vasculature"
9:50 am - 10:00 am
10:00 am - 10:20 am
Geetika Nehra (Univeristy of Kentucky / Sanders-Brown Center on Aging, United States) "Aß Pathology: A Driver of Blood-Brain Barrier Leakage in Alzheimer’s Disease?"
10:20 am - 10:30 am
10:30 am - 10:50 am
Claire O'Connor (Smurfit Institute of Genetics, Trinity College Dublin, Ireland) "AAV-Mediated Regulation of Claudin-5 at the Blood Brain Barrier as a Gene Therapy Based Approach for Neurological Disorders"
10:50 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Academic Labs in the Digital Age
In this session we would like to discuss with junior investigators their journeys to becoming an independent investigator and cover topics relevant to the modern academic lab such as: The use of internet and social media for data sharing, funding, and visibility; The use of preprint services, wikis, blogs, and video journals; The use of unique funding mechanisms (e.g., crowd-sourced funding); How they run a modern lab: electronic lab notebooks, management styles, being eco-conscious; New and unique ways to engage the community online or virtually during the pandemic.
Matthew Campbell (Trinity College Dublin, Ireland) and William Elmquist (University of Minnesota, United States)
1:30 pm - 2:30 pm
Academic Labs in the Digital Age
Jakob Körbelin (University Medical Center Hamburg-Eppendorf, Germany)
Ethan Lippmann (Vanderbilt University, United States)
Roosmarijn Vandenbroucke (VIB, Ghent University, Belgium)
Dionna Williams (Johns Hopkins University, United States)
2:30 pm - 3:00 pm
Fill in GRS Evaluation Forms