| THURSDAY |
| 2:00 pm - 5:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 8:50 pm | JOINT SESSION WITH METALS IN BIOLOGY |
| Introduction: Thomas O'Halloran (Northwestern) |
| Harry Gray (Cal tech)
Electron Tunneling Wires for Metalloproteins |
| 9:15 pm - ?:?? pm | Poster Session (Presented by GRS) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Conference Photo |
| METALLOENZYME KINETICS AND MECHANISM |
| 9:00 am - 9:15 am | CHAIR: Paul Lindahl (Texas A&M University) |
| 9:15 am - 9:50 am | Matthew Ryle, Michigan State University
Transient, O2-generated Tyrosyl Radical in TauD, an α-Keto Acid-Dependent Non-Heme Iron Dioxygenase
|
| 9:50 am - 10:25 am | Huay-Keng Loke, Texas A&M University
Mini-Metalloproteins of the Ni-Fe-S Active Site of Acetyl-CoA Synthase |
| 10:25 am - 10:45 am | COFFEE BREAK |
| 10:45 am - 11:20 am | Tiffany Reiter, The Mayo Clinic Rochester
Calcineurin is a Peroxide Specific Sensor in T Lymphocytes |
| 11:20 am - 11:55 am | Peng Chen, Stanford University
CuZ in N2O Reductase: Spectroscopy, Electronic Structure and Mechanism |
| 11:55 am - 12:30 pm | Bryan Schmidt, Michigan State University
In Search of the Water and Proton Exit Routes in Cytochrome c Oxidase Using Buried Mn as a Probe |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm - 7:15 pm | Dinner |
| RATIONAL AND COMBINATORIAL METALLOPROTEIN DESIGN |
| 7:30 pm - 7:40 pm | CHAIR: Brian Gibney (Columbia University) |
| 7:40 pm - 8:15 pm | Steven Berry, University of Illinois at Urbana Champaign
The 21st Amino Acid and Beyond: Novel Copper Sites in Azurin |
| 8:15 pm - 8:50 pm | Michelle Kennedy, Columbia University
[4Fe-4S]2+/+ and [4Fe-4Se]2+/+ Designed Peptides |
| 8:50 pm - 9:25 pm | Patrick Cirino, California Institute of Technology
Directed Evolution of the Peroxide Shunt Pathway in Cytochrome P450 BM-3 |
| 9:25 pm - 10:00 pm | Brian T. Farrer, University of Michigan
Thermodynamic Model for the Stabilization of Trigonal Thiolato Hg(II) in Designed Three-Helix Bundles |
| SATURDAY |
| 7:30 am - 8:30 am | Breakfast |
| METAL - NUCLEOTIDE INTERACTIONS AND ELECTRON TRANSFER |
| 9:00 am - 9:15 am | CHAIR: Yi Lu (Univ. Illinois) |
| 9:15 am - 9:50 am | Mario Pennella, Texas A&M University
Characterization of the Metallorgulatory Transcriptional Repressor S. aureus CzrA |
| 9:50 am - 10:25 am | Craig Claussen, Indiana University Purdue University Indianapolis
Sequence-selective DNA Recognition and Binding by Combinatorial Libraries of Ni(II)·Xaa-Xaa-His Metallopeptides Incorporating L- and D-Amino Acids |
| 10:25 am - 10:45 am | COFFEE BREAK |
| 10:45 am - 11:20 am | Peter Gordon, University of Chicago
Metal ion catalysis during group II intron self-splicing |
| 11:20 am - 11:55 am | Elizabeth Boon, California Institute of Technology
Electrochemical Probes of DNA Stacking and Protein-DNA Interactions |
| 11:55 am - 12:30 pm | Lei Li, Johns Hopkins University
Targeted Strand Scission of DNA Substrates by Copper(II) Coordination Complexes |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm - 7:15 pm | Dinner |
| SMALL - MOLECULE MODELS OF PROTEIN ACTIVE SITES |
| 7:30 pm - 7:40 pm | CHAIR: William Tolman (University of Minnesota) |
| 7:40 pm - 8:15 pm | Roman Shimanovich, Princeton University
Oxo-Iron Porphyrins in Water, novel chemically generated Compund I mimics |
| 8:15 pm - 8:50 pm | Nick Rubie, University of New Mexico
Electronic structure studies of the xanthine oxidase relevant cis-MOS unit: Implications for an orientation dependant reaction mechanism |
| 8:50 pm - 9:25 pm | Audria Stubna, Carnegie Mellon University
Model Compounds for Compound Q |
| 9:25 pm - 10:00 pm | Mark Mehn, University of Minnesota
Why are α-Keto Acids Used as Cofactors for Many Mononuclear Nonheme Iron Enzymes? |
| 10:00 pm - 10:15 pm | Business Meeting |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| METALLOPROTEIN FOLDING AND MOLECULAR STRUCTURE |
| 9:00 am - 9:15 am | CHAIR: Catherine Drennan (MIT) |
| 9:15 am - 9:50 am | Jennifer Stine-Elam, University of Texas Health Science Center at San Antonio
X-ray Structure of FALS Mutant CuZnSOD D125H Reveals Zinc and Sulfate Ion Bound in the Catalytic Site: Implications for the Role of Bicarbonate in Peroxidative Reactions Catalyzed by CuZnSOD |
| 9:50 am - 10:25 am | Irina Pozdnyakova, Tulane University
Role of Copper Cofactor in Azurin Folding |
| 10:25 am - 10:45 am | COFFEE BREAK |
| 10:45 am - 11:20 am | Bill Desmarais, University of Chicago
The Role of Metal Ions in Bridged Bimetallic Systems: A Study at Ultra-High Resolution |
| 11:20 am - 11:55 am | Markus Ribbe and Benedikt Schmid, University of California Irvine and California Institute of Technology
Structure and Biochemical Properties of FeMo cofactor-deficient MoFe Protein Variants of Nitrogenase - Implications for Cofactor Insertion and Active Site Assembly |
| 11:55 am - 12:30 pm | Jennifer Lee, California Institute of Technology
Electron transfer triggered folding of cytochrome c': probing the role of ligand substitution in the formation of four-helix bundles |
| 12:30 pm | Lunch |
| 12:30 pm | Conference Ends |
